14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME (2000) Mol Cell 6: 41-51 Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation. Chiang CW, Harris G, Ellig C, Masters SC, Subramanian R, Shenolikar S, Wadzinski BE, Yang E (2001) Blood 97: 1289-97 Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells. Rice PL, Washington M, Schleman S, Beard KS, Driggers LJ, Ahnen DJ (2003) Cancer Res 63: 616-20 BAD/BCL-[X(L)] heterodimerization leads to bypass of G0/G1 arrest. Chattopadhyay A, Chiang CW, Yang E (2001) Oncogene 20: 4507-18 Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice. Babaev VR, Yeung M, Erbay E, Ding L, Zhang Y, May JM, Fazio S, Hotamisligil GS, Linton MF (2016) Arterioscler Thromb Vasc Biol 36: 1122-31 Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Chiang CW, Kanies C, Kim KW, Fang WB, Parkhurst C, Xie M, Henry T, Yang E (2003) Mol Cell Biol 23: 6350-62 Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL. Kelekar A, Chang BS, Harlan JE, Fesik SW, Thompson CB (1997) Mol Cell Biol 17: 7040-6 RNA suppression of ERK2 leads to collapse of mitochondrial membrane potential with acute oxidative stress in human lens epithelial cells. Flynn JM, Lannigan DA, Clark DE, Garner MH, Cammarata PR (2008) Am J Physiol Endocrinol Metab 294: E589-99 Defining the p53 DNA-binding domain/Bcl-x(L)-binding interface using NMR. Petros AM, Gunasekera A, Xu N, Olejniczak ET, Fesik SW (2004) FEBS Lett 559: 171-4 Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Petros AM, Nettesheim DG, Wang Y, Olejniczak ET, Meadows RP, Mack J, Swift K, Matayoshi ED, Zhang H, Thompson CB, Fesik SW (2000) Protein Sci 9: 2528-34 The Bcl-2-associated death promoter (BAD) lowers the threshold at which the Bcl-2-interacting domain death agonist (BID) triggers mitochondria disintegration. Howells CC, Baumann WT, Samuels DC, Finkielstein CV (2011) J Theor Biol 271: 114-23
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