Keyword Connections

•  Aliya Gifford

•  David Wasserman

Resources

• Body composition measurements

Communities

• Wasserman Lab

Publications

• Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation.
  Chu AY, Deng X, Fisher VA, Drong A, Zhang Y, Feitosa MF, Liu CT, Weeks O, Choh AC, Duan Q, Dyer TD, Eicher JD, Guo X, Heard-Costa NL, Kacprowski T, Kent JW, Lange LA, Liu X, Lohman K, Lu L, Mahajan A, O'Connell JR, Parihar A, Peralta JM, Smith AV, Zhang Y, Homuth G, Kissebah AH, Kullberg J, Laqua R, Launer LJ, Nauck M, Olivier M, Peyser PA, Terry JG, Wojczynski MK, Yao J, Bielak LF, Blangero J, Borecki IB, Bowden DW, Carr JJ, Czerwinski SA, Ding J, Friedrich N, Gudnason V, Harris TB, Ingelsson E, Johnson AD, Kardia SL, Langefeld CD, Lind L, Liu Y, Mitchell BD, Morris AP, Mosley TH, Rotter JI, Shuldiner AR, Towne B, Völzke H, Wallaschofski H, Wilson JG, Allison M, Lindgren CM, Goessling W, Cupples LA, Steinhauser ML, Fox CS
  (2017) Nat Genet 49: 125-130
• Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.
  Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM
  (2014) Cell 156: 304-16
• Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.
  Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y
  (2006) Science 312: 1656-9
• Maternal microbial molecules affect offspring health.
  Ferguson J
  (2020) Science 367: 978-979
• Association between duration of overall and abdominal obesity beginning in young adulthood and coronary artery calcification in middle age.
  Reis JP, Loria CM, Lewis CE, Powell-Wiley TM, Wei GS, Carr JJ, Terry JG, Liu K
  (2013) JAMA 310: 280-8
• Effects of dietary composition on energy expenditure during weight-loss maintenance.
  Ebbeling CB, Swain JF, Feldman HA, Wong WW, Hachey DL, Garcia-Lago E, Ludwig DS
  (2012) JAMA 307: 2627-34
• Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.
  Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW
  (2016) Nat Med 22: 800-6
• Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
  Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N
  (2007) Nat Med 13: 1193-202
• Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.
  An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB
  (2004) Nat Med 10: 268-74
• Dietary Fat Intake and Lung Cancer Risk: A Pooled Analysis.
  Yang JJ, Yu D, Takata Y, Smith-Warner SA, Blot W, White E, Robien K, Park Y, Xiang YB, Sinha R, Lazovich D, Stampfer M, Tumino R, Aune D, Overvad K, Liao L, Zhang X, Gao YT, Johansson M, Willett W, Zheng W, Shu XO
  (2017) J Clin Oncol 35: 3055-3064
• Fish oil treatment decreases superoxide anions in the myocardium and coronary arteries of atherosclerotic monkeys.
  Supari F, Ungerer T, Harrison DG, Williams JK
  (1995) Circulation 91: 1123-8
• Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.
  Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS
  (2004) Circulation 110: 1492-8
• Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study.
  Djoussé L, Arnett DK, Carr JJ, Eckfeldt JH, Hopkins PN, Province MA, Ellison RC, Investigators of the NHLBI FHS
  (2005) Circulation 111: 2921-6
• Nonfatal acute myocardial infarction in Costa Rica: modifiable risk factors, population-attributable risks, and adherence to dietary guidelines.
  Kabagambe EK, Baylin A, Campos H
  (2007) Circulation 115: 1075-81
• Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25.
  Mullaney BC, Blind RD, Lemieux GA, Perez CL, Elle IC, Faergeman NJ, Van Gilst MR, Ingraham HA, Ashrafi K
  (2010) Cell Metab 12: 398-410
• AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.
  Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M
  (2011) Cell Metab 13: 376-388
• Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults.
  Fabbrini E, Tamboli RA, Magkos F, Marks-Shulman PA, Eckhauser AW, Richards WO, Klein S, Abumrad NN
  (2010) Gastroenterology 139: 448-55
• Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery.
  Albaugh VL, Banan B, Antoun J, Xiong Y, Guo Y, Ping J, Alikhan M, Clements BA, Abumrad NN, Flynn CR
  (2019) Gastroenterology 156: 1041-1051.e4
• Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats.
  Sato H, Zhang LS, Martinez K, Chang EB, Yang Q, Wang F, Howles PN, Hokari R, Miura S, Tso P
  (2016) Gastroenterology 151: 923-932
• Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.
  Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ
  (2009) J Clin Invest 119: 2577-89
• Hepatic β-arrestin 2 is essential for maintaining euglycemia.
  Zhu L, Rossi M, Cui Y, Lee RJ, Sakamoto W, Perry NA, Urs NM, Caron MG, Gurevich VV, Godlewski G, Kunos G, Chen M, Chen W, Wess J
  (2017) J Clin Invest 127: 2941-2945
• Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells.
  Crossno JT, Majka SM, Grazia T, Gill RG, Klemm DJ
  (2006) J Clin Invest 116: 3220-8
• Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.
  Purcell-Huynh DA, Farese RV, Johnson DF, Flynn LM, Pierotti V, Newland DL, Linton MF, Sanan DA, Young SG
  (1995) J Clin Invest 95: 2246-57
• Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans.
  Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin CT, Price JW, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DH, Neufer PD
  (2009) J Clin Invest 119: 573-81
• Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity.
  Chen Z, Guo L, Zhang Y, Walzem RL, Pendergast JS, Printz RL, Morris LC, Matafonova E, Stien X, Kang L, Coulon D, McGuinness OP, Niswender KD, Davies SS
  (2014) J Clin Invest 124: 3391-406
• Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis.
  Berglund ED, Liu C, Sohn JW, Liu T, Kim MH, Lee CE, Vianna CR, Williams KW, Xu Y, Elmquist JK
  (2013) J Clin Invest 123: 5061-70
• 2-Aminoadipic acid is a biomarker for diabetes risk.
  Wang TJ, Ngo D, Psychogios N, Dejam A, Larson MG, Vasan RS, Ghorbani A, O'Sullivan J, Cheng S, Rhee EP, Sinha S, McCabe E, Fox CS, O'Donnell CJ, Ho JE, Florez JC, Magnusson M, Pierce KA, Souza AL, Yu Y, Carter C, Light PE, Melander O, Clish CB, Gerszten RE
  (2013) J Clin Invest 123: 4309-17
• Isolation and characterization of hepatic Golgi lipoproteins from hypercholesterolemic rats.
  Swift LL, Manowitz NR, Dunn GD, LeQuire VS
  (1980) J Clin Invest 66: 415-25
• Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse.
  Overton CD, Yancey PG, Major AS, Linton MF, Fazio S
  (2007) Circ Res 100: 670-7
• Systemic delivery of microRNA-181b inhibits nuclear factor-κB activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice.
  Sun X, He S, Wara AKM, Icli B, Shvartz E, Tesmenitsky Y, Belkin N, Li D, Blackwell TS, Sukhova GK, Croce K, Feinberg MW
  (2014) Circ Res 114: 32-40
• Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment in patients with suspected NASH.
  Ohki T, Tateishi R, Shiina S, Goto E, Sato T, Nakagawa H, Masuzaki R, Goto T, Hamamura K, Kanai F, Yoshida H, Kawabe T, Omata M
  (2009) Gut 58: 839-44
• HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.
  Ferrari A, Longo R, Fiorino E, Silva R, Mitro N, Cermenati G, Gilardi F, Desvergne B, Andolfo A, Magagnotti C, Caruso D, Fabiani E, Hiebert SW, Crestani M
  (2017) Nat Commun 8: 93
• β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions.
  Zhu L, Almaça J, Dadi PK, Hong H, Sakamoto W, Rossi M, Lee RJ, Vierra NC, Lu H, Cui Y, McMillin SM, Perry NA, Gurevich VV, Lee A, Kuo B, Leapman RD, Matschinsky FM, Doliba NM, Urs NM, Caron MG, Jacobson DA, Caicedo A, Wess J
  (2017) Nat Commun 8: 14295
• S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease.
  Martínez-Uña M, Varela-Rey M, Mestre D, Fernández-Ares L, Fresnedo O, Fernandez-Ramos D, Gutiérrez-de Juan V, Martin-Guerrero I, García-Orad A, Luka Z, Wagner C, Lu SC, García-Monzón C, Finnell RH, Aurrekoetxea I, Buqué X, Martínez-Chantar ML, Mato JM, Aspichueta P
  (2015) J Hepatol 62: 673-81
• Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance.
  Wu L, Parekh VV, Hsiao J, Kitamura D, Van Kaer L
  (2014) Proc Natl Acad Sci U S A 111: E4638-47
• Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance.
  Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, Magnuson MA
  (2005) Proc Natl Acad Sci U S A 102: 6207-12
• Melanocortin-4 receptor mutations paradoxically reduce preference for palatable foods.
  Panaro BL, Cone RD
  (2013) Proc Natl Acad Sci U S A 110: 7050-5
• Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice.
  Wu L, Parekh VV, Gabriel CL, Bracy DP, Marks-Shulman PA, Tamboli RA, Kim S, Mendez-Fernandez YV, Besra GS, Lomenick JP, Williams B, Wasserman DH, Van Kaer L
  (2012) Proc Natl Acad Sci U S A 109: E1143-52
• Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth.
  Wang D, Fu L, Ning W, Guo L, Sun X, Dey SK, Chaturvedi R, Wilson KT, DuBois RN
  (2014) Proc Natl Acad Sci U S A 111: 7084-9
• Circadian disruption leads to insulin resistance and obesity.
  Shi SQ, Ansari TS, McGuinness OP, Wasserman DH, Johnson CH
  (2013) Curr Biol 23: 372-81