Keyword Connections

•  Danxia Yu
•  Joshua Fessel

•  Michelle Armstrong
•  Pinelopi Kapitsinou

•  Ruey Hu
•  Vanessa Allwardt

Resources

• Metabolomics Analysis Sub-Core

Communities

• Center for Innovative Technology

Publications

• Metabolite profiles and the risk of developing diabetes.
  Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C, O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A, Melander O, Clish CB, Gerszten RE
  (2011) Nat Med 17: 448-53
• Metabolite profiling identifies pathways associated with metabolic risk in humans.
  Cheng S, Rhee EP, Larson MG, Lewis GD, McCabe EL, Shen D, Palma MJ, Roberts LD, Dejam A, Souza AL, Deik AA, Magnusson M, Fox CS, O'Donnell CJ, Vasan RS, Melander O, Clish CB, Gerszten RE, Wang TJ
  (2012) Circulation 125: 2222-31
• A genome-wide association study of the human metabolome in a community-based cohort.
  Rhee EP, Ho JE, Chen MH, Shen D, Cheng S, Larson MG, Ghorbani A, Shi X, Helenius IT, O'Donnell CJ, Souza AL, Deik A, Pierce KA, Bullock K, Walford GA, Vasan RS, Florez JC, Clish C, Yeh JR, Wang TJ, Gerszten RE
  (2013) Cell Metab 18: 130-43
• Working towards an exegesis for lipids in biology.
  Brown HA, Murphy RC
  (2009) Nat Chem Biol 5: 602-6
• 2-Aminoadipic acid is a biomarker for diabetes risk.
  Wang TJ, Ngo D, Psychogios N, Dejam A, Larson MG, Vasan RS, Ghorbani A, O'Sullivan J, Cheng S, Rhee EP, Sinha S, McCabe E, Fox CS, O'Donnell CJ, Ho JE, Florez JC, Magnusson M, Pierce KA, Souza AL, Yu Y, Carter C, Light PE, Melander O, Clish CB, Gerszten RE
  (2013) J Clin Invest 123: 4309-17
• On sharing quantitative trait GWAS results in an era of multiple-omics data and the limits of genomic privacy.
  Im HK, Gamazon ER, Nicolae DL, Cox NJ
  (2012) Am J Hum Genet 90: 591-8
• Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle.
  Talati MH, Brittain EL, Fessel JP, Penner N, Atkinson J, Funke M, Grueter C, Jerome WG, Freeman M, Newman JH, West J, Hemnes AR
  (2016) Am J Respir Crit Care Med 194: 719-28
• Metabolic signatures of exercise in human plasma.
  Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE
  (2010) Sci Transl Med 2: 33ra37
• Ion mobility conformational lipid atlas for high confidence lipidomics.
  Leaptrot KL, May JC, Dodds JN, McLean JA
  (2019) Nat Commun 10: 985
• Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics.
  Earl DC, Ferrell PB, Leelatian N, Froese JT, Reisman BJ, Irish JM, Bachmann BO
  (2018) Nat Commun 9: 39
• Improving the discovery of secondary metabolite natural products using ion mobility-mass spectrometry.
  Schrimpe-Rutledge AC, Sherrod SD, McLean JA
  (2018) Curr Opin Chem Biol 42: 160-166
• A combined epidemiologic and metabolomic approach improves CKD prediction.
  Rhee EP, Clish CB, Ghorbani A, Larson MG, Elmariah S, McCabe E, Yang Q, Cheng S, Pierce K, Deik A, Souza AL, Farrell L, Domos C, Yeh RW, Palacios I, Rosenfield K, Vasan RS, Florez JC, Wang TJ, Fox CS, Gerszten RE
  (2013) J Am Soc Nephrol 24: 1330-8
• Serum metabolites are associated with all-cause mortality in chronic kidney disease.
  Hu JR, Coresh J, Inker LA, Levey AS, Zheng Z, Rebholz CM, Tin A, Appel LJ, Chen J, Sarnak MJ, Grams ME
  (2018) Kidney Int 94: 381-389
• Metabolite profiles during oral glucose challenge.
  Ho JE, Larson MG, Vasan RS, Ghorbani A, Cheng S, Rhee EP, Florez JC, Clish CB, Gerszten RE, Wang TJ
  (2013) Diabetes 62: 2689-98
• Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation.
  Bauer JA, Chakravarthy AB, Rosenbluth JM, Mi D, Seeley EH, De Matos Granja-Ingram N, Olivares MG, Kelley MC, Mayer IA, Meszoely IM, Means-Powell JA, Johnson KN, Tsai CJ, Ayers GD, Sanders ME, Schneider RJ, Formenti SC, Caprioli RM, Pietenpol JA
  (2010) Clin Cancer Res 16: 681-90
• Functionally oriented analysis of cardiometabolic traits in a trans-ethnic sample.
  Petty LE, Highland HM, Gamazon ER, Hu H, Karhade M, Chen HH, de Vries PS, Grove ML, Aguilar D, Bell GI, Huff CD, Hanis CL, Doddapaneni H, Munzy DM, Gibbs RA, Ma J, Parra EJ, Cruz M, Valladares-Salgado A, Arking DE, Barbeira A, Im HK, Morrison AC, Boerwinkle E, Below JE
  (2019) Hum Mol Genet 28: 1212-1224
• Branched-Chain Amino Acids and Cardiovascular Disease: Does Diet Matter?
  Ferguson JF, Wang TJ
  (2016) Clin Chem 62: 545-7
• Carbon and nitrogen provisions alter the metabolic flux in developing soybean embryos.
  Allen DK, Young JD
  (2013) Plant Physiol 161: 1458-75
• Characterizing proteins of unknown function: orphan cytochrome p450 enzymes as a paradigm.
  Guengerich FP, Tang Z, Salamanca-Pinzón SG, Cheng Q
  (2010) Mol Interv 10: 153-63
• Identifying novel biomarkers for cardiovascular disease risk prediction.
  Ge Y, Wang TJ
  (2012) J Intern Med 272: 430-9
• Prospective study of blood metabolites associated with colorectal cancer risk.
  Shu X, Xiang YB, Rothman N, Yu D, Li HL, Yang G, Cai H, Ma X, Lan Q, Gao YT, Jia W, Shu XO, Zheng W
  (2018) Int J Cancer 143: 527-534
• Phenotypic mapping of metabolic profiles using self-organizing maps of high-dimensional mass spectrometry data.
  Goodwin CR, Sherrod SD, Marasco CC, Bachmann BO, Schramm-Sapyta N, Wikswo JP, McLean JA
  (2014) Anal Chem 86: 6563-71
• Multianalyte microphysiometry reveals changes in cellular bioenergetics upon exposure to fluorescent dyes.
  Shinawi TF, Kimmel DW, Cliffel DE
  (2013) Anal Chem 85: 11677-80
• Elucidation of functions of human cytochrome P450 enzymes: identification of endogenous substrates in tissue extracts using metabolomic and isotopic labeling approaches.
  Tang Z, Martin MV, Guengerich FP
  (2009) Anal Chem 81: 3071-8
• Untargeted Molecular Discovery in Primary Metabolism: Collision Cross Section as a Molecular Descriptor in Ion Mobility-Mass Spectrometry.
  Nichols CM, Dodds JN, Rose BS, Picache JA, Morris CB, Codreanu SG, May JC, Sherrod SD, McLean JA
  (2018) Anal Chem 90: 14484-14492
• High-throughput quantification of bioactive lipids by MALDI mass spectrometry: application to prostaglandins.
  Manna JD, Reyzer ML, Latham JC, Weaver CD, Marnett LJ, Caprioli RM
  (2011) Anal Chem 83: 6683-8
• Measurement of monovalent and polyvalent carbohydrate-lectin binding by back-scattering interferometry.
  Kussrow A, Kaltgrad E, Wolfenden ML, Cloninger MJ, Finn MG, Bornhop DJ
  (2009) Anal Chem 81: 4889-97
• EXIMS: an improved data analysis pipeline based on a new peak picking method for EXploring Imaging Mass Spectrometry data.
  Wijetunge CD, Saeed I, Boughton BA, Spraggins JM, Caprioli RM, Bacic A, Roessner U, Halgamuge SK
  (2015) Bioinformatics 31: 3198-206
• Differentiating short- and long-term effects of diet in the obese mouse using (1) H-nuclear magnetic resonance metabolomics.
  Duggan GE, Hittel DS, Hughey CC, Weljie A, Vogel HJ, Shearer J
  (2011) Diabetes Obes Metab 13: 859-62
• Serum Metabolite Profiles Are Altered by Erlotinib Treatment and the Integrin α1-Null Genotype but Not by Post-Traumatic Osteoarthritis.
  Mickiewicz B, Shin SY, Pozzi A, Vogel HJ, Clark AL
  (2016) J Proteome Res 15: 815-25
• An Integrated, High-Throughput Strategy for Multiomic Systems Level Analysis.
  Gutierrez DB, Gant-Branum RL, Romer CE, Farrow MA, Allen JL, Dahal N, Nei YW, Codreanu SG, Jordan AT, Palmer LD, Sherrod SD, McLean JA, Skaar EP, Norris JL, Caprioli RM
  (2018) J Proteome Res 17: 3396-3408
• Evaluation of affinity-tagged protein expression strategies using local and global isotope ratio measurements.
  Hervey WJ, Khalsa-Moyers G, Lankford PK, Owens ET, McKeown CK, Lu TY, Foote LJ, Asano KG, Morrell-Falvey JL, McDonald WH, Pelletier DA, Hurst GB
  (2009) J Proteome Res 8: 3675-88
• Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms.
  Nes CR, Singha UK, Liu J, Ganapathy K, Villalta F, Waterman MR, Lepesheva GI, Chaudhuri M, Nes WD
  (2012) Biochem J 443: 267-77
• Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle.
  DeBalsi KL, Wong KE, Koves TR, Slentz DH, Seiler SE, Wittmann AH, Ilkayeva OR, Stevens RD, Perry CG, Lark DS, Hui ST, Szweda L, Neufer PD, Muoio DM
  (2014) J Biol Chem 289: 8106-20
• Thiobenzothiazole-modified Hydrocortisones Display Anti-inflammatory Activity with Reduced Impact on Islet β-Cell Function.
  Burke SJ, May AL, Noland RC, Lu D, Brissova M, Powers AC, Sherrill EM, Karlstad MD, Campagna SR, Stephens JM, Collier JJ
  (2015) J Biol Chem 290: 13401-16
• Metabolomics in epidemiology: sources of variability in metabolite measurements and implications.
  Sampson JN, Boca SM, Shu XO, Stolzenberg-Solomon RZ, Matthews CE, Hsing AW, Tan YT, Ji BT, Chow WH, Cai Q, Liu DK, Yang G, Xiang YB, Zheng W, Sinha R, Cross AJ, Moore SC
  (2013) Cancer Epidemiol Biomarkers Prev 22: 631-40