C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons. Miller DM, Shen MM, Shamu CE, Bürglin TR, Ruvkun G, Dubois ML, Ghee M, Wilson L (1992) Nature 355: 841-5 The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Howard HC, Mount DB, Rochefort D, Byun N, Dupré N, Lu J, Fan X, Song L, Rivière JB, Prévost C, Horst J, Simonati A, Lemcke B, Welch R, England R, Zhan FQ, Mercado A, Siesser WB, George AL, McDonald MP, Bouchard JP, Mathieu J, Delpire E, Rouleau GA (2002) Nat Genet 32: 384-92 Aberrant cannabinoid signaling impairs oviductal transport of embryos. Wang H, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK, DuBois RN, Dey SK (2004) Nat Med 10: 1074-80 Modified structure of the human serotonin transporter promoter. Flattem NL, Blakely RD (2000) Mol Psychiatry 5: 110-5 The E6-Ap ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region. Sutcliffe JS, Jiang YH, Galijaard RJ, Matsuura T, Fang P, Kubota T, Christian SL, Bressler J, Cattanach B, Ledbetter DH, Beaudet AL (1997) Genome Res 7: 368-77 Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a). Linton MF, Farese RV, Chiesa G, Grass DS, Chin P, Hammer RE, Hobbs HH, Young SG (1993) J Clin Invest 92: 3029-37 Particle-mediated gene transfer with transforming growth factor-beta1 cDNAs enhances wound repair in rat skin. Benn SI, Whitsitt JS, Broadley KN, Nanney LB, Perkins D, He L, Patel M, Morgan JR, Swain WF, Davidson JM (1996) J Clin Invest 98: 2894-902 Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice. Brandt SJ, Bodine DM, Dunbar CE, Nienhuis AW (1990) J Clin Invest 86: 592-9 A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Davis AC, Wims M, Spotts GD, Hann SR, Bradley A (1993) Genes Dev 7: 671-82 Lsh, a member of the SNF2 family, is required for genome-wide methylation. Dennis K, Fan T, Geiman T, Yan Q, Muegge K (2001) Genes Dev 15: 2940-4 Analysis of iceA genotypes in South African Helicobacter pylori strains and relationship to clinically significant disease. Kidd M, Peek RM, Lastovica AJ, Israel DA, Kummer AF, Louw JA (2001) Gut 49: 629-35 Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG (1995) Proc Natl Acad Sci U S A 92: 4917-21 Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Tranguch S, Cheung-Flynn J, Daikoku T, Prapapanich V, Cox MB, Xie H, Wang H, Das SK, Smith DF, Dey SK (2005) Proc Natl Acad Sci U S A 102: 14326-31 Perp is a mediator of p53-dependent apoptosis in diverse cell types. Ihrie RA, Reczek E, Horner JS, Khachatrian L, Sage J, Jacks T, Attardi LD (2003) Curr Biol 13: 1985-90 Stage-specific Arf tumor suppression in Notch1-induced T-cell acute lymphoblastic leukemia. Volanakis EJ, Williams RT, Sherr CJ (2009) Blood 114: 4451-9 Absence of phorbol ester-induced down-regulation of myc protein in the phorbol ester-tolerant mutant of HL-60 promyelocytes. Gailani D, Cadwell FJ, O'Donnell PS, Hromas RA, Macfarlane DE (1989) Cancer Res 49: 5329-33 FHIT gene expression in human ovarian, endometrial, and cervical cancer cell lines. Hendricks DT, Taylor R, Reed M, Birrer MJ (1997) Cancer Res 57: 2112-5 Restriction landmark genome scanning for aberrant methylation in primary refractory and relapsed acute myeloid leukemia; involvement of the WIT-1 gene. Plass C, Yu F, Yu L, Strout MP, El-Rifai W, Elonen E, Knuutila S, Marcucci G, Young DC, Held WA, Bloomfield CD, Caligiuri MA (1999) Oncogene 18: 3159-65 Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells. Wang P, Lushnikova T, Odvody J, Greiner TC, Jones SN, Eischen CM (2008) Oncogene 27: 1590-8 Mtbp haploinsufficiency in mice increases tumor metastasis. Iwakuma T, Tochigi Y, Van Pelt CS, Caldwell LC, Terzian T, Parant JM, Chau GP, Koch JG, Eischen CM, Lozano G (2008) Oncogene 27: 1813-20 Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development. Eischen CM, Alt JR, Wang P (2004) Oncogene 23: 8931-40 Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin. Pestina TI, Hargrove PW, Jay D, Gray JT, Boyd KM, Persons DA (2009) Mol Ther 17: 245-52 PiggyBac transposon-based inducible gene expression in vivo after somatic cell gene transfer. Saridey SK, Liu L, Doherty JE, Kaja A, Galvan DL, Fletcher BS, Wilson MH (2009) Mol Ther 17: 2115-20 Compound heterozygous mutations (Arg 239----stop, Pro 342----Thr) in the CYP17 (P45017 alpha) gene lead to ambiguous external genitalia in a male patient with partial combined 17 alpha-hydroxylase/17,20-lyase deficiency. Ahlgren R, Yanase T, Simpson ER, Winter JS, Waterman MR (1992) J Clin Endocrinol Metab 74: 667-72 Combined 17 alpha-hydroxylase/17,20-lyase deficiency due to a 7-basepair duplication in the N-terminal region of the cytochrome P45017 alpha (CYP17) gene. Yanase T, Sanders D, Shibata A, Matsui N, Simpson ER, Waterman MR (1990) J Clin Endocrinol Metab 70: 1325-9 Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines. Labosky PA, Barlow DP, Hogan BL (1994) Development 120: 3197-204 Human papillomavirus infection and other risk factors for cervical neoplasia: a case-control study. Morrison EA, Ho GY, Vermund SH, Goldberg GL, Kadish AS, Kelley KF, Burk RD (1991) Int J Cancer 49: 6-13 Buschke-Ollendorff syndrome associated with elevated elastin production by affected skin fibroblasts in culture. Giro MG, Duvic M, Smith LT, Kennedy R, Rapini R, Arnett FC, Davidson JM (1992) J Invest Dermatol 99: 129-37 Association of mycoplasma and human immunodeficiency virus infection: detection of amplified Mycoplasma fermentans DNA in blood. Hawkins RE, Rickman LS, Vermund SH, Carl M (1992) J Infect Dis 165: 581-5 The high-mobility-group box protein SSRP1/T160 is essential for cell viability in day 3.5 mouse embryos. Cao S, Bendall H, Hicks GG, Nashabi A, Sakano H, Shinkai Y, Gariglio M, Oltz EM, Ruley HE (2003) Mol Cell Biol 23: 5301-7 Telomerase activity and oncogenesis in giant cell tumor of bone. Schwartz HS, Juliao SF, Sciadini MF, Miller LK, Butler MG (1995) Cancer 75: 1094-9 Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer. Slebos RJ, Evers SG, Wagenaar SS, Rodenhuis S (1989) Br J Cancer 59: 76-80 Differences in the capacity of reovirus strains to induce apoptosis are determined by the viral attachment protein sigma 1. Tyler KL, Squier MK, Rodgers SE, Schneider BE, Oberhaus SM, Grdina TA, Cohen JJ, Dermody TS (1995) J Virol 69: 6972-9 Functions of the sequences at the ends of the inverted repeats of pseudorabies virus. Rall GF, Kupershmidt S, Sugg N, Veach RA, Ben-Porat T (1992) J Virol 66: 1506-19 Epstein-Barr virus gH is essential for penetration of B cells but also plays a role in attachment of virus to epithelial cells. Molesworth SJ, Lake CM, Borza CM, Turk SM, Hutt-Fletcher LM (2000) J Virol 74: 6324-32 Identification of cellular promoters by using a retrovirus promoter trap. von Melchner H, Ruley HE (1989) J Virol 63: 3227-33 Retrovirus promoter-trap vector to induce lacZ gene fusions in mammalian cells. Reddy S, DeGregori JV, von Melchner H, Ruley HE (1991) J Virol 65: 1507-15 Type 1 fimbriae mutants of Escherichia coli K12: characterization of recognized afimbriate strains and construction of new fim deletion mutants. Blomfield IC, McClain MS, Eisenstein BI (1991) Mol Microbiol 5: 1439-45 Rat P450(17 alpha) from testis: characterization of a full-length cDNA encoding a unique steroid hydroxylase capable of catalyzing both delta 4- and delta 5-steroid-17,20-lyase reactions. Fevold HR, Lorence MC, McCarthy JL, Trant JM, Kagimoto M, Waterman MR, Mason JI (1989) Mol Endocrinol 3: 968-75 Deletion within the CYP17 gene together with insertion of foreign DNA is the cause of combined complete 17 alpha-hydroxylase/17,20-lyase deficiency in an Italian patient. Biason A, Mantero F, Scaroni C, Simpson ER, Waterman MR (1991) Mol Endocrinol 5: 2037-45
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.