Keyword Connections

•  Agnes Fogo
•  Daniel Gochberg

•  Harold Moses
•  Kevin Ess

Resources

• B10.129S6-Tsc2{tm1.1Kcess}/Vu

Communities

• Ess Lab

Publications

• Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier.
  Arima Y, Harada M, Kamimura D, Park JH, Kawano F, Yull FE, Kawamoto T, Iwakura Y, Betz UA, Márquez G, Blackwell TS, Ohira Y, Hirano T, Murakami M
  (2012) Cell 148: 447-57
• A 'Tsc, Tsc' keeps the kids quie(scen)t and holds down ROS.
  Boothby M, Lee K
  (2011) Nat Immunol 12: 811-2
• Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging.
  Ciccarelli O, Barkhof F, Bodini B, De Stefano N, Golay X, Nicolay K, Pelletier D, Pouwels PJ, Smith SA, Wheeler-Kingshott CA, Stankoff B, Yousry T, Miller DH
  (2014) Lancet Neurol 13: 807-22
• An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice.
  Traykova-Brauch M, Schönig K, Greiner O, Miloud T, Jauch A, Bode M, Felsher DW, Glick AB, Kwiatkowski DJ, Bujard H, Horst J, von Knebel Doeberitz M, Niggli FK, Kriz W, Gröne HJ, Koesters R
  (2008) Nat Med 14: 979-84
• Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.
  Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SSW, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan KC, Maniatis T, Taylor JP
  (2014) Neuron 81: 536-543
• Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation.
  Liu Q, Sanai N, Jin WN, La Cava A, Van Kaer L, Shi FD
  (2016) Nat Neurosci 19: 243-52
• Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology.
  Hao J, Liu R, Piao W, Zhou Q, Vollmer TL, Campagnolo DI, Xiang R, La Cava A, Van Kaer L, Shi FD
  (2010) J Exp Med 207: 1907-21
• Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
  Manousaki D, Dudding T, Haworth S, Hsu YH, Liu CT, Medina-Gómez C, Voortman T, van der Velde N, Melhus H, Robinson-Cohen C, Cousminer DL, Nethander M, Vandenput L, Noordam R, Forgetta V, Greenwood CMT, Biggs ML, Psaty BM, Rotter JI, Zemel BS, Mitchell JA, Taylor B, Lorentzon M, Karlsson M, Jaddoe VVW, Tiemeier H, Campos-Obando N, Franco OH, Utterlinden AG, Broer L, van Schoor NM, Ham AC, Ikram MA, Karasik D, de Mutsert R, Rosendaal FR, den Heijer M, Wang TJ, Lind L, Orwoll ES, Mook-Kanamori DO, Michaëlsson K, Kestenbaum B, Ohlsson C, Mellström D, de Groot LCPGM, Grant SFA, Kiel DP, Zillikens MC, Rivadeneira F, Sawcer S, Timpson NJ, Richards JB
  (2017) Am J Hum Genet 101: 227-238
• Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.
  Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden DM
  (2010) Am J Hum Genet 86: 560-72
• Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients.
  Dutta R, McDonough J, Yin X, Peterson J, Chang A, Torres T, Gudz T, Macklin WB, Lewis DA, Fox RJ, Rudick R, Mirnics K, Trapp BD
  (2006) Ann Neurol 59: 478-89
• Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis.
  Sriram S, Stratton CW, Yao S, Tharp A, Ding L, Bannan JD, Mitchell WM
  (1999) Ann Neurol 46: 6-14
• Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model.
  Wong M, Ess KC, Uhlmann EJ, Jansen LA, Li W, Crino PB, Mennerick S, Yamada KA, Gutmann DH
  (2003) Ann Neurol 54: 251-6
• Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation.
  Hao J, Campagnolo D, Liu R, Piao W, Shi S, Hu B, Xiang R, Zhou Q, Vollmer T, Van Kaer L, La Cava A, Shi FD
  (2011) Ann Neurol 69: 721-34
• The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis.
  Liang X, Wang Q, Shi J, Lokteva L, Breyer RM, Montine TJ, Andreasson K
  (2008) Ann Neurol 64: 304-14
• Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis.
  Nichols NL, Gowing G, Satriotomo I, Nashold LJ, Dale EA, Suzuki M, Avalos P, Mulcrone PL, McHugh J, Svendsen CN, Mitchell GS
  (2013) Am J Respir Crit Care Med 187: 535-42
• Targeting B lymphocytes in progressive fibrosing mediastinitis.
  Westerly BD, Johnson GB, Maldonado F, Utz JP, Specks U, Peikert T
  (2014) Am J Respir Crit Care Med 190: 1069-71
• Genome-Wide Association Study of 58 Individuals with Fibrosing Mediastinitis Reveals Possible Underlying Genetic Susceptibility.
  Richmond BW, Guo Y, Yu C, Kendall PL, Mason WR, Cogan JD, Loyd JE
  (2018) Am J Respir Crit Care Med 197: 1219-1220
• Defective structural RNA processing in relapsing-remitting multiple sclerosis.
  Spurlock CF, Tossberg JT, Guo Y, Sriram S, Crooke PS, Aune TM
  (2015) Genome Biol 16: 58
• Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
  Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M
  (2011) Nat Commun 2: 334
• Activation of the ciliary neurotrophic factor (CNTF) signalling pathway in cortical neurons of multiple sclerosis patients.
  Dutta R, McDonough J, Chang A, Swamy L, Siu A, Kidd GJ, Rudick R, Mirnics K, Trapp BD
  (2007) Brain 130: 2566-76
• What is influencing the phenotype of the common homozygous polymerase-γ mutation p.Ala467Thr?
  Neeve VC, Samuels DC, Bindoff LA, van den Bosch B, Van Goethem G, Smeets H, Lombès A, Jardel C, Hirano M, Dimauro S, De Vries M, Smeitink J, Smits BW, de Coo IF, Saft C, Klopstock T, Keiling BC, Czermin B, Abicht A, Lochmüller H, Hudson G, Gorman GG, Turnbull DM, Taylor RW, Holinski-Feder E, Chinnery PF, Horvath R
  (2012) Brain 135: 3614-26
• Spatial distribution of multiple sclerosis lesions in the cervical spinal cord.
  Eden D, Gros C, Badji A, Dupont SM, De Leener B, Maranzano J, Zhuoquiong R, Liu Y, Granberg T, Ouellette R, Stawiarz L, Hillert J, Talbott J, Bannier E, Kerbrat A, Edan G, Labauge P, Callot V, Pelletier J, Audoin B, Rasoanandrianina H, Brisset JC, Valsasina P, Rocca MA, Filippi M, Bakshi R, Tauhid S, Prados F, Yiannakas M, Kearney H, Ciccarelli O, Smith SA, Andrada Treaba C, Mainero C, Lefeuvre J, Reich DS, Nair G, Shepherd TM, Charlson E, Tachibana Y, Hori M, Kamiya K, Chougar L, Narayanan S, Cohen-Adad J
  (2019) Brain 142: 633-646
• Multiple sclerosis lesions affect intrinsic functional connectivity of the spinal cord.
  Conrad BN, Barry RL, Rogers BP, Maki S, Mishra A, Thukral S, Sriram S, Bhatia A, Pawate S, Gore JC, Smith SA
  (2018) Brain 141: 1650-1664
• MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme.
  Suh SS, Yoo JY, Nuovo GJ, Jeon YJ, Kim S, Lee TJ, Kim T, Bakàcs A, Alder H, Kaur B, Aqeilan RI, Pichiorri F, Croce CM
  (2012) Proc Natl Acad Sci U S A 109: 5316-21
• Phospholipase D1 is an effector of Rheb in the mTOR pathway.
  Sun Y, Fang Y, Yoon MS, Zhang C, Roccio M, Zwartkruis FJ, Armstrong M, Brown HA, Chen J
  (2008) Proc Natl Acad Sci U S A 105: 8286-91
• Dynamic tubers in tuberous sclerosis complex: A window for intervention?
  Ess KC, Chugani HT
  (2015) Neurology 85: 1530-1
• Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex.
  Ess KC, Kamp CA, Tu BP, Gutmann DH
  (2005) Neurology 64: 1446-9
• Spinal cord imaging in multiple sclerosis: filling the gap with the brain.
  De Stefano N, Smith SA
  (2014) Neurology 83: 1306-7
• Spinal cord quantitative MRI discriminates between disability levels in multiple sclerosis.
  Oh J, Saidha S, Chen M, Smith SA, Prince J, Jones C, Diener-West M, van Zijl PC, Reich DS, Calabresi PA
  (2013) Neurology 80: 540-7
• New therapies for tuber-less sclerosis: white matter matters?
  Ess KC, Roach ES
  (2012) Neurology 78: 520-1
• Increased CSF F2-isoprostane concentration in probable AD.
  Montine TJ, Beal MF, Cudkowicz ME, O'Donnell H, Margolin RA, McFarland L, Bachrach AF, Zackert WE, Roberts LJ, Morrow JD
  (1999) Neurology 52: 562-5
• Endogenous double-stranded Alu RNA elements stimulate IFN-responses in relapsing remitting multiple sclerosis.
  Heinrich MJ, Purcell CA, Pruijssers AJ, Zhao Y, Spurlock CF, Sriram S, Ogden KM, Dermody TS, Scholz MB, Crooke PS, Karijolich J, Aune TM
  (2019) J Autoimmun 100: 40-51
• Is focal segmental glomerulosclerosis really focal? Distribution of lesions in adults and children.
  Fogo A, Glick AD, Horn SL, Horn RG
  (1995) Kidney Int 47: 1690-6
• The clot thickens.
  Fogo AB
  (2006) Kidney Int 70: 620-1
• Role for "uremic toxin" in the progressive loss of intact nephrons in chronic renal failure.
  Motojima M, Nishijima F, Ikoma M, Kawamura T, Yoshioka T, Fogo AB, Sakai T, Ichikawa I
  (1991) Kidney Int 40: 461-9