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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to Protein Kinase C are shown below. Double-click or tap a node for more information.
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- Protein kinase C phosphorylates pp60src at a novel site.
Gould KL, Woodgett JR, Cooper JA, Buss JE, Shalloway D, Hunter T
(1985) Cell 42: 849-57 - Distinct patterns of expression of different protein kinase C mRNAs in rat tissues.
Brandt SJ, Niedel JE, Bell RM, Young WS
(1987) Cell 49: 57-63 - Neurobiology. Dopamine's reversal of fortune.
Blakely RD
(2001) Science 293: 2407-9 - Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants.
Ramamoorthy S, Blakely RD
(1999) Science 285: 763-6 - Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.
Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S
(2005) Cancer Cell 8: 155-67 - Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis.
McCaffrey LM, Montalbano J, Mihai C, Macara IG
(2012) Cancer Cell 22: 601-14 - Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N
(2007) Nat Med 13: 1193-202 - EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity.
Löf-Öhlin ZM, Nyeng P, Bechard ME, Hess K, Bankaitis E, Greiner TU, Ameri J, Wright CV, Semb H
(2017) Nat Cell Biol 19: 1313-1325 - Axon growth-stimulus package includes local translation.
Macara IG, Iioka H, Mili S
(2009) Nat Cell Biol 11: 919-21 - Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways.
Lee K, Gudapati P, Dragovic S, Spencer C, Joyce S, Killeen N, Magnuson MA, Boothby M
(2010) Immunity 32: 743-53 - Potentiation of cAMP responses by metabotropic glutamate receptors depresses excitatory synaptic transmission by a kinase-independent mechanism.
Gereau RW, Conn PJ
(1994) Neuron 12: 1121-9 - Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems.
Alagarsamy S, Marino MJ, Rouse ST, Gereau RW, Heinemann SF, Conn PJ
(1999) Nat Neurosci 2: 234-40 - Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT.
Cremona ML, Matthies HJ, Pau K, Bowton E, Speed N, Lute BJ, Anderson M, Sen N, Robertson SD, Vaughan RA, Rothman JE, Galli A, Javitch JA, Yamamoto A
(2011) Nat Neurosci 14: 469-77 - Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression.
Lintas C, Sacco R, Garbett K, Mirnics K, Militerni R, Bravaccio C, Curatolo P, Manzi B, Schneider C, Melmed R, Elia M, Pascucci T, Puglisi-Allegra S, Reichelt KL, Persico AM
(2009) Mol Psychiatry 14: 705-18 - The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase.
Zhang H, Macara IG
(2008) Dev Cell 14: 216-26 - Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.
Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ
(2009) J Clin Invest 119: 2577-89 - Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting.
Guan Y, Zhang Y, Wu J, Qi Z, Yang G, Dou D, Gao Y, Chen L, Zhang X, Davis LS, Wei M, Fan X, Carmosino M, Hao C, Imig JD, Breyer RM, Breyer MD
(2007) J Clin Invest 117: 2496-505 - Modulation of human platelet protein kinase C by endotoxic lipid A.
Grabarek J, Timmons S, Hawiger J
(1988) J Clin Invest 82: 964-71 - The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis.
McCaffrey LM, Macara IG
(2009) Genes Dev 23: 1450-60 - Modulation of an inactivating human cardiac K+ channel by protein kinase C.
Murray KT, Fahrig SA, Deal KK, Po SS, Hu NN, Snyders DJ, Tamkun MM, Bennett PB
(1994) Circ Res 75: 999-1005 - Functional effects of protein kinase C activation on the human cardiac Na+ channel.
Murray KT, Hu NN, Daw JR, Shin HG, Watson MT, Mashburn AB, George AL
(1997) Circ Res 80: 370-6 - Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-β isoform in the endothelium.
Li Q, Park K, Li C, Rask-Madsen C, Mima A, Qi W, Mizutani K, Huang P, King GL
(2013) Circ Res 113: 418-27 - The high osmolarity glycerol response (HOG) MAP kinase pathway controls localization of a yeast golgi glycosyltransferase.
Reynolds TB, Hopkins BD, Lyons MR, Graham TR
(1998) J Cell Biol 143: 935-46 - PDGF induction of alpha 2 integrin gene expression is mediated by protein kinase C-zeta.
Xu J, Zutter MM, Santoro SA, Clark RA
(1996) J Cell Biol 134: 1301-11 - Loss of protein kinase C inhibition in the beta-T594M variant of the amiloride-sensitive Na+ channel.
Cui Y, Su YR, Rutkowski M, Reif M, Menon AG, Pun RY
(1997) Proc Natl Acad Sci U S A 94: 9962-6 - Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).
Bhave G, Hu HJ, Glauner KS, Zhu W, Wang H, Brasier DJ, Oxford GS, Gereau RW
(2003) Proc Natl Acad Sci U S A 100: 12480-5 - Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance.
Münzel T, Giaid A, Kurz S, Stewart DJ, Harrison DG
(1995) Proc Natl Acad Sci U S A 92: 5244-8 - The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells.
Nirodi CS, Crews BC, Kozak KR, Morrow JD, Marnett LJ
(2004) Proc Natl Acad Sci U S A 101: 1840-5 - The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers.
Qian J, Hassanein M, Hoeksema MD, Harris BK, Zou Y, Chen H, Lu P, Eisenberg R, Wang J, Espinosa A, Ji X, Harris FT, Rahman SM, Massion PP
(2015) Proc Natl Acad Sci U S A 112: 3469-74 - PKC eta regulates occludin phosphorylation and epithelial tight junction integrity.
Suzuki T, Elias BC, Seth A, Shen L, Turner JR, Giorgianni F, Desiderio D, Guntaka R, Rao R
(2009) Proc Natl Acad Sci U S A 106: 61-6 - Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins.
Hao Y, Du Q, Chen X, Zheng Z, Balsbaugh JL, Maitra S, Shabanowitz J, Hunt DF, Macara IG
(2010) Curr Biol 20: 1809-18 - Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins.
Blakely RD, Ramamoorthy S, Schroeter S, Qian Y, Apparsundaram S, Galli A, DeFelice LJ
(1998) Biol Psychiatry 44: 169-78 - Phosphorylation of topoisomerase II by casein kinase II and protein kinase C: effects on enzyme-mediated DNA cleavage/religation and sensitivity to the antineoplastic drugs etoposide and 4'-(9-acridinylamino)methane-sulfon-m-anisidide.
DeVore RF, Corbett AH, Osheroff N
(1992) Cancer Res 52: 2156-61 - p185c-erbB-2 signal enhances cisplatin-induced cytotoxicity in human breast carcinoma cells: association between an oncogenic receptor tyrosine kinase and drug-induced DNA repair.
Arteaga CL, Winnier AR, Poirier MC, Lopez-Larraza DM, Shawver LK, Hurd SD, Stewart SJ
(1994) Cancer Res 54: 3758-65 - Intrarenal distribution of rabbit PKC zeta.
Hao CM, Breyer RM, Davis LS, Breyer MD
(1997) Kidney Int 51: 1831-7 - Dietary fatty acid modulates glomerular atrial natriuretic peptide receptor.
Awazu M, Yared A, Swift LL, Hoover RL, Ichikawa I
(1992) Kidney Int 42: 265-71 - MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol.
Domina AM, Vrana JA, Gregory MA, Hann SR, Craig RW
(2004) Oncogene 23: 5301-15 - Coordinate regulation of metabotropic glutamate receptors.
Alagarsamy S, Sorensen SD, Conn PJ
(2001) Curr Opin Neurobiol 11: 357-62
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