Production and auto-induction of transforming growth factor-alpha in human keratinocytes. Coffey RJ, Derynck R, Wilcox JN, Bringman TS, Goustin AS, Moses HL, Pittelkow MR (1987) Nature 328: 817-20 Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CV, Van de Casteele M, German MS, Bouwens L, Heimberg H (2014) Nat Biotechnol 32: 76-83 Cytokine-driven beta-cell production in vivo. Worchel HN, Magnuson MA (2014) Nat Biotechnol 32: 63-4 HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Wang SE, Narasanna A, Perez-Torres M, Xiang B, Wu FY, Yang S, Carpenter G, Gazdar AF, Muthuswamy SK, Arteaga CL (2006) Cancer Cell 10: 25-38 Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer. Miller VA, Kris MG, Shah N, Patel J, Azzoli C, Gomez J, Krug LM, Pao W, Rizvi N, Pizzo B, Tyson L, Venkatraman E, Ben-Porat L, Memoli N, Zakowski M, Rusch V, Heelan RT (2004) J Clin Oncol 22: 1103-9 Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neurons. Emtage L, Gu G, Hartwieg E, Chalfie M (2004) Neuron 44: 795-807 Regulated intramembrane proteolysis takes another twist. Huppert S, Kopan R (2001) Dev Cell 1: 590-2 Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Barnard JA, Beauchamp RD, Russell WE, Dubois RN, Coffey RJ (1995) Gastroenterology 108: 564-80 Increased gastroduodenal concentrations of transforming growth factor alpha in adaptation to aspirin in monkeys and rats. Romano M, Lesch CA, Meise KS, Veljaca M, Sanchez B, Kraus ER, Boland CR, Guglietta A, Coffey RJ (1996) Gastroenterology 110: 1448-55 Increased production of transforming growth factor alpha following acute gastric injury. Polk WH, Dempsey PJ, Russell WE, Brown PI, Beauchamp RD, Barnard JA, Coffey RJ (1992) Gastroenterology 102: 1467-74 Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Means AL, Ray KC, Singh AB, Washington MK, Whitehead RH, Harris RC, Wright CV, Coffey RJ, Leach SD (2003) Gastroenterology 124: 1020-36 Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury. Homma T, Sakai M, Cheng HF, Yasuda T, Coffey RJ, Harris RC (1995) J Clin Invest 96: 1018-25 Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. Regales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, Koutcher JA, Spassova M, Ouerfelli O, Mellinghoff IK, Zakowski MF, Politi KA, Pao W (2009) J Clin Invest 119: 3000-10 Production of heparin binding epidermal growth factor-like growth factor in the early phase of regeneration after acute renal injury. Isolation and localization of bioactive molecules. Sakai M, Zhang M, Homma T, Garrick B, Abraham JA, McKanna JA, Harris RC (1997) J Clin Invest 99: 2128-38 Evidence for glomerular actions of epidermal growth factor in the rat. Harris RC, Hoover RL, Jacobson HR, Badr KF (1988) J Clin Invest 82: 1028-39 Helicobacter pylori upregulates expression of epidermal growth factor-related peptides, but inhibits their proliferative effect in MKN 28 gastric mucosal cells. Romano M, Ricci V, Di Popolo A, Sommi P, Del Vecchio Blanco C, Bruni CB, Ventura U, Cover TL, Blaser MJ, Coffey RJ, Zarrilli R (1998) J Clin Invest 101: 1604-13 Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue. Pasic L, Eisinger-Mathason TS, Velayudhan BT, Moskaluk CA, Brenin DR, Macara IG, Lannigan DA (2011) Genes Dev 25: 1641-53 Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases. de Caestecker MP, Parks WT, Frank CJ, Castagnino P, Bottaro DP, Roberts AB, Lechleider RJ (1998) Genes Dev 12: 1587-92 Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution. Schenk S, Hintermann E, Bilban M, Koshikawa N, Hojilla C, Khokha R, Quaranta V (2003) J Cell Biol 161: 197-209 Apical enrichment of human EGF precursor in Madin-Darby canine kidney cells involves preferential basolateral ectodomain cleavage sensitive to a metalloprotease inhibitor. Dempsey PJ, Meise KS, Yoshitake Y, Nishikawa K, Coffey RJ (1997) J Cell Biol 138: 747-58 Site-specific mapping and quantification of protein S-sulphenylation in cells. Yang J, Gupta V, Carroll KS, Liebler DC (2014) Nat Commun 5: 4776 Electron microscopy of whole cells in liquid with nanometer resolution. de Jonge N, Peckys DB, Kremers GJ, Piston DW (2009) Proc Natl Acad Sci U S A 106: 2159-64 Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit. Ackerman P, Glover CV, Osheroff N (1990) Proc Natl Acad Sci U S A 87: 821-5 Epidermal growth factor stimulates substrate-selective protein-tyrosine-phosphatase activity. Hernández-Sotomayor SM, Arteaga CL, Soler C, Carpenter G (1993) Proc Natl Acad Sci U S A 90: 7691-5 Inhibition of the mitogenic effects of plasma by a monoclonal antibody to somatomedin C. Russell WE, Van Wyk JJ, Pledger WJ (1984) Proc Natl Acad Sci U S A 81: 2389-92 Synthetic somatomedin C: comparison with natural hormone isolated from human plasma. Van Wyk JJ, Russell WE, Li CH (1984) Proc Natl Acad Sci U S A 81: 740-2 Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells. Chen JK, Capdevila J, Harris RC (2002) Proc Natl Acad Sci U S A 99: 6029-34 Transformation of polarized epithelial cells by apical mistrafficking of epiregulin. Singh B, Bogatcheva G, Washington MK, Coffey RJ (2013) Proc Natl Acad Sci U S A 110: 8960-5 Induction of collecting duct morphogenesis in vitro by heparin-binding epidermal growth factor-like growth factor. Takemura T, Hino S, Kuwajima H, Yanagida H, Okada M, Nagata M, Sasaki S, Barasch J, Harris RC, Yoshioka K (2001) J Am Soc Nephrol 12: 964-72 Extraction of a melanoma growth-stimulatory activity from culture medium conditioned by the Hs0294 human melanoma cell line. Richmond A, Lawson DH, Nixon DW, Stevens JS, Chawla RK (1983) Cancer Res 43: 2106-12 Epidermal growth factor receptor monoclonal antibody inhibits constitutive receptor phosphorylation, reduces autonomous growth, and sensitizes androgen-independent prostatic carcinoma cells to tumor necrosis factor alpha. Fong CJ, Sherwood ER, Mendelsohn J, Lee C, Kozlowski JM (1992) Cancer Res 52: 5887-92 Immunodetection and modulation of cellular growth with antibodies against native transforming growth factor-beta 1. Keski-Oja J, Lyons RM, Moses HL (1987) Cancer Res 47: 6451-8 Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells. Rice PL, Washington M, Schleman S, Beard KS, Driggers LJ, Ahnen DJ (2003) Cancer Res 63: 616-20 Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis. Ricono JM, Huang M, Barnes LA, Lau SK, Weis SM, Schlaepfer DD, Hanks SK, Cheresh DA (2009) Cancer Res 69: 1383-91 Growth modulation of mouse keratinocytes by transforming growth factors. Coffey RJ, Sipes NJ, Bascom CC, Graves-Deal R, Pennington CY, Weissman BE, Moses HL (1988) Cancer Res 48: 1596-602 Epidermal growth factor receptors in human breast carcinoma cells: a potential selective target for transforming growth factor alpha-Pseudomonas exotoxin 40 fusion protein. Arteaga CL, Hurd SD, Dugger TC, Winnier AR, Robertson JB (1994) Cancer Res 54: 4703-9 Changes in gene expression after temporary renal ischemia. Safirstein R, Price PM, Saggi SJ, Harris RC (1990) Kidney Int 37: 1515-21 Role of membrane-bound heparin-binding epidermal growth factor-like growth factor (HB-EGF) in renal epithelial cell branching. Takemura T, Hino S, Okada M, Murata Y, Yanagida H, Ikeda M, Yoshioka K, Harris RC (2002) Kidney Int 61: 1968-79 Coexpression of CD9 augments the ability of membrane-bound heparin-binding epidermal growth factor-like growth factor (proHB-EGF) to preserve renal epithelial cell viability. Takemura T, Hino S, Murata Y, Yanagida H, Okada M, Yoshioka K, Harris RC (1999) Kidney Int 55: 71-81 DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition. Higgins DF, Lappin DW, Kieran NE, Anders HJ, Watson RW, Strutz F, Schlondorff D, Haase VH, Fitzpatrick JM, Godson C, Brady HR (2003) Kidney Int 64: 2079-91
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