MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Lynch CC, Hikosaka A, Acuff HB, Martin MD, Kawai N, Singh RK, Vargo-Gogola TC, Begtrup JL, Peterson TE, Fingleton B, Shirai T, Matrisian LM, Futakuchi M (2005) Cancer Cell 7: 485-96 Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent. Yancey PG, Ding Y, Fan D, Blakemore JL, Zhang Y, Ding L, Zhang J, Linton MF, Fazio S (2011) Circulation 124: 454-64 Mild renal dysfunction and metabolites tied to low HDL cholesterol are associated with monocytosis and atherosclerosis. Ganda A, Magnusson M, Yvan-Charvet L, Hedblad B, Engström G, Ai D, Wang TJ, Gerszten RE, Melander O, Tall AR (2013) Circulation 127: 988-96 Toward a unified theory of renal progression. Harris RC, Neilson EG (2006) Annu Rev Med 57: 365-80 Immune cell populations in cutaneous delayed-type hypersensitivity. Platt JL, Grant BW, Eddy AA, Michael AF (1983) J Exp Med 158: 1227-42 Novel Pseudomonas product stimulates interleukin-8 production in airway epithelial cells in vitro. Massion PP, Inoue H, Richman-Eisenstat J, Grunberger D, Jorens PG, Housset B, Pittet JF, Wiener-Kronish JP, Nadel JA (1994) J Clin Invest 93: 26-32 Collagen-induced release of interleukin 1 from human blood mononuclear cells. Potentiation by fibronectin binding to the alpha 5 beta 1 integrin. Pacifici R, Basilico C, Roman J, Zutter MM, Santoro SA, McCracken R (1992) J Clin Invest 89: 61-7 Pathological and immunological effects of ingesting L-tryptophan and 1,1'-ethylidenebis (L-tryptophan) in Lewis rats. Love LA, Rader JI, Crofford LJ, Raybourne RB, Principato MA, Page SW, Trucksess MW, Smith MJ, Dugan EM, Turner ML (1993) J Clin Invest 91: 804-11 Monocyte-T lymphocyte interaction for regulation of insulin receptors of the activated T lymphocyte. Helderman JH, Ayuso R, Rosenstock J, Raskin P (1987) J Clin Invest 79: 566-71 Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection. Reyes-Robles T, Alonzo F, Kozhaya L, Lacy DB, Unutmaz D, Torres VJ (2013) Cell Host Microbe 14: 453-9 Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase. Sorescu GP, Song H, Tressel SL, Hwang J, Dikalov S, Smith DA, Boyd NL, Platt MO, Lassègue B, Griendling KK, Jo H (2004) Circ Res 95: 773-9 Prednisone increases PGH-synthase 2 in atopic humans in vivo. Dworski RT, Funk CD, Oates JA, Sheller JR (1997) Am J Respir Crit Care Med 155: 351-7 TGF-β receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms. Novitskiy SV, Pickup MW, Gorska AE, Owens P, Chytil A, Aakre M, Wu H, Shyr Y, Moses HL (2011) Cancer Discov 1: 430-41 Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics. Earl DC, Ferrell PB, Leelatian N, Froese JT, Reisman BJ, Irish JM, Bachmann BO (2018) Nat Commun 9: 39 Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth. Wang D, Fu L, Ning W, Guo L, Sun X, Dey SK, Chaturvedi R, Wilson KT, DuBois RN (2014) Proc Natl Acad Sci U S A 111: 7084-9 Proangiogenic role of neutrophil-like inflammatory heterophils during neovascularization induced by growth factors and human tumor cells. Zijlstra A, Seandel M, Kupriyanova TA, Partridge JJ, Madsen MA, Hahn-Dantona EA, Quigley JP, Deryugina EI (2006) Blood 107: 317-27 IkappaB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells. Hawiger J, Veach RA, Liu XY, Timmons S, Ballard DW (1999) Blood 94: 1711-6 Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions. Eddy AA (1994) J Am Soc Nephrol 5: 1273-87 Transforming growth factor beta (TGF-beta) and inflammation in cancer. Bierie B, Moses HL (2010) Cytokine Growth Factor Rev 21: 49-59 Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site. Li B, Vincent A, Cates J, Brantley-Sieders DM, Polk DB, Young PP (2009) Cancer Res 69: 338-48 Interstitial inflammation and fibrosis in rats with diet-induced hypercholesterolemia. Eddy AA (1996) Kidney Int 50: 1139-49 Detection of abnormal peripheral blood mononuclear cell cytokine networks in human IgA nephropathy. de Caestecker MP, Bottomley M, Telfer BA, Hutchinson IV, Vose BM, Ballardie FW (1993) Kidney Int 44: 1298-308 Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria. Eddy AA, Giachelli CM (1995) Kidney Int 47: 1546-57 Impaired monocyte cytokine production in critically ill patients with acute renal failure. Himmelfarb J, Le P, Klenzak J, Freedman S, McMenamin ME, Ikizler TA, PICARD Group (2004) Kidney Int 66: 2354-60 Transforming growth factor-beta is involved in the pathogenesis of dialysis-related amyloidosis. Matsuo K, Ikizler TA, Hoover RL, Nakamoto M, Yasunaga C, Pupim LB, Hakim RM (2000) Kidney Int 57: 697-708 Safety and biological activity of repeated doses of recombinant human Flt3 ligand in patients with bone scan-negative hormone-refractory prostate cancer. Higano CS, Vogelzang NJ, Sosman JA, Feng A, Caron D, Small EJ (2004) Clin Cancer Res 10: 1219-25 6-Mercaptopurine, monocytes, and atherosclerosis. Linton MF, Fazio S (2010) Arterioscler Thromb Vasc Biol 30: 1494-6 EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis. Funk SD, Yurdagul A, Albert P, Traylor JG, Jin L, Chen J, Orr AW (2012) Arterioscler Thromb Vasc Biol 32: 686-95 Loss of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition. Zhu L, Giunzioni I, Tavori H, Covarrubias R, Ding L, Zhang Y, Ormseth M, Major AS, Stafford JM, Linton MF, Fazio S (2016) Arterioscler Thromb Vasc Biol 36: 1483-95 Cellular dynamics in early atherosclerotic lesion progression in white carneau pigeons. Spatial and temporal analysis of monocyte and smooth muscle invasion of the intima. Jerome WG, Lewis JC (1997) Arterioscler Thromb Vasc Biol 17: 654-64 Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice. Babaev VR, Ding L, Zhang Y, May JM, Ramsey SA, Vickers KC, Linton MF (2019) Arterioscler Thromb Vasc Biol 39: 156-169 Tissue-specific RNA-Seq in human evoked inflammation identifies blood and adipose LincRNA signatures of cardiometabolic diseases. Liu Y, Ferguson JF, Xue C, Ballantyne RL, Silverman IM, Gosai SJ, Serfecz J, Morley MP, Gregory BD, Li M, Reilly MP (2014) Arterioscler Thromb Vasc Biol 34: 902-12 Delayed wound healing in CXCR2 knockout mice. Devalaraja RM, Nanney LB, Du J, Qian Q, Yu Y, Devalaraja MN, Richmond A (2000) J Invest Dermatol 115: 234-44 Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL. Ohba T, Cole HA, Cates JM, Slosky DA, Haro H, Ando T, Schwartz HS, Schoenecker JG (2014) J Bone Miner Res 29: 1431-45 Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide. Loperena R, Van Beusecum JP, Itani HA, Engel N, Laroumanie F, Xiao L, Elijovich F, Laffer CL, Gnecco JS, Noonan J, Maffia P, Jasiewicz-Honkisz B, Czesnikiewicz-Guzik M, Mikolajczyk T, Sliwa T, Dikalov S, Weyand CM, Guzik TJ, Harrison DG (2018) Cardiovasc Res 114: 1547-1563 Adipose tissue recruitment of leukocytes. Anderson EK, Gutierrez DA, Hasty AH (2010) Curr Opin Lipidol 21: 172-7 Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system. Buckman LB, Hasty AH, Flaherty DK, Buckman CT, Thompson MM, Matlock BK, Weller K, Ellacott KL (2014) Brain Behav Immun 35: 33-42 Tissue-specific regulation of IL-6 production by IL-4. Differential effects of IL-4 on nuclear factor-kappa B activity in monocytes and fibroblasts. Donnelly RP, Crofford LJ, Freeman SL, Buras J, Remmers E, Wilder RL, Fenton MJ (1993) J Immunol 151: 5603-12 Monocytes are potent facilitators of alveolar neutrophil emigration during lung inflammation: role of the CCL2-CCR2 axis. Maus UA, Waelsch K, Kuziel WA, Delbeck T, Mack M, Blackwell TS, Christman JW, Schlöndorff D, Seeger W, Lohmeyer J (2003) J Immunol 170: 3273-8 CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Zhang DE, Hetherington CJ, Meyers S, Rhoades KL, Larson CJ, Chen HM, Hiebert SW, Tenen DG (1996) Mol Cell Biol 16: 1231-40
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.