A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997) Nature 390: 192-6 Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC (2013) Cell 155: 844-57 Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Rameh LE, Chen CS, Cantley LC (1995) Cell 83: 821-30 A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. Odom AR, Stahlberg A, Wente SR, York JD (2000) Science 287: 2026-9 Regulation of chromatin remodeling by inositol polyphosphates. Steger DJ, Haswell ES, Miller AL, Wente SR, O'Shea EK (2003) Science 299: 114-6 A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. York JD, Odom AR, Murphy R, Ives EB, Wente SR (1999) Science 285: 96-100 The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H (2009) Nat Immunol 10: 769-77 mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM (2009) Cancer Cell 15: 148-59 Inositol polyphosphates regulate zebrafish left-right asymmetry. Sarmah B, Latimer AJ, Appel B, Wente SR (2005) Dev Cell 9: 133-45 A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC, Ross AH (2004) J Cell Biol 166: 205-11 Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis. Legate KR, Takahashi S, Bonakdar N, Fabry B, Boettiger D, Zent R, Fässler R (2011) EMBO J 30: 4539-53 A role for the inositol kinase Ipk1 in ciliary beating and length maintenance. Sarmah B, Winfrey VP, Olson GE, Appel B, Wente SR (2007) Proc Natl Acad Sci U S A 104: 19843-8 The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation. Carricaburu V, Lamia KA, Lo E, Favereaux L, Payrastre B, Cantley LC, Rameh LE (2003) Proc Natl Acad Sci U S A 100: 9867-72 Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Park SW, Kim M, Kim JY, Brown KM, Haase VH, D'Agati VD, Lee HT (2012) Kidney Int 82: 878-91 RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors. Morgan-Lappe S, Woods KW, Li Q, Anderson MG, Schurdak ME, Luo Y, Giranda VL, Fesik SW, Leverson JD (2006) Oncogene 25: 1340-8 Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study. Junyent M, Parnell LD, Lai CQ, Lee YC, Smith CE, Arnett DK, Tsai MY, Kabagambe EK, Straka RJ, Province M, An P, Borecki I, Ordovás JM (2009) Am J Clin Nutr 90: 686-94 Important role for AMPKalpha1 in limiting skeletal muscle cell hypertrophy. Mounier R, Lantier L, Leclerc J, Sotiropoulos A, Pende M, Daegelen D, Sakamoto K, Foretz M, Viollet B (2009) FASEB J 23: 2264-73 Fragments of ATM which have dominant-negative or complementing activity. Morgan SE, Lovly C, Pandita TK, Shiloh Y, Kastan MB (1997) Mol Cell Biol 17: 2020-9 Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH (2005) Mol Cell Biol 25: 3163-72 Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression. Jhun BH, Rose DW, Seely BL, Rameh L, Cantley L, Saltiel AR, Olefsky JM (1994) Mol Cell Biol 14: 7466-75 Identification and characterization of a phosphoinositide phosphate kinase homolog. Chang JD, Field SJ, Rameh LE, Carpenter CL, Cantley LC (2004) J Biol Chem 279: 11672-9 The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase. Verbsky JW, Wilson MP, Kisseleva MV, Majerus PW, Wente SR (2002) J Biol Chem 277: 31857-62 The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase. Chang SC, Miller AL, Feng Y, Wente SR, Majerus PW (2002) J Biol Chem 277: 43836-43 Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway. Miller AL, Suntharalingam M, Johnson SL, Audhya A, Emr SD, Wente SR (2004) J Biol Chem 279: 51022-32 The effects of wortmannin on rat skeletal muscle. Dissociation of signaling pathways for insulin- and contraction-activated hexose transport. Yeh JI, Gulve EA, Rameh L, Birnbaum MJ (1995) J Biol Chem 270: 2107-11 Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate. Tolias KF, Rameh LE, Ishihara H, Shibasaki Y, Chen J, Prestwich GD, Cantley LC, Carpenter CL (1998) J Biol Chem 273: 18040-6 Inactivation of NF-kappaB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K. Gao Z, Yin J, Zhang J, He Q, McGuinness OP, Ye J (2009) J Biol Chem 284: 18368-76 Generation of Chinese hamster ovary cell glycosylation mutants by retroviral insertional mutagenesis. Integration into a discrete locus generates mutants expressing high levels of N-glycolylneuraminic acid. Hubbard SC, Walls L, Ruley HE, Muchmore EA (1994) J Biol Chem 269: 3717-24 Biochemical and functional characterization of inositol 1,3,4,5, 6-pentakisphosphate 2-kinases. Ives EB, Nichols J, Wente SR, York JD (2000) J Biol Chem 275: 36575-83 Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease. Di Pardo A, Amico E, Basit A, Armirotti A, Joshi P, Neely MD, Vuono R, Castaldo S, Digilio AF, Scalabrì F, Pepe G, Elifani F, Madonna M, Jeong SK, Park BM, D'Esposito M, Bowman AB, Barker RA, Maglione V (2017) Sci Rep 7: 5280 Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism. Malabanan MM, Blind RD (2016) Biochem Soc Trans 44: 279-85 Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway. Neitzel LR, Spencer ZT, Nayak A, Cselenyi CS, Benchabane H, Youngblood CQ, Zouaoui A, Ng V, Stephens L, Hann T, Patton JG, Robbins D, Ahmed Y, Lee E (2019) Mech Dev 156: 20-31
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