The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide. Sánchez-Pedregal VM, Kubicek K, Meiler J, Lyothier I, Paterson I, Carlomagno T (2006) Angew Chem Int Ed Engl 45: 7388-94 The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents. Carlomagno T, Blommers MJ, Meiler J, Jahnke W, Schupp T, Petersen F, Schinzer D, Altmann KH, Griesinger C (2003) Angew Chem Int Ed Engl 42: 2511-5 Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution. Reese M, Sánchez-Pedregal VM, Kubicek K, Meiler J, Blommers MJ, Griesinger C, Carlomagno T (2007) Angew Chem Int Ed Engl 46: 1864-8 Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. Efimov A, Kharitonov A, Efimova N, Loncarek J, Miller PM, Andreyeva N, Gleeson P, Galjart N, Maia AR, McLeod IX, Yates JR, Maiato H, Khodjakov A, Akhmanova A, Kaverina I (2007) Dev Cell 12: 917-30 Microtubule targeting of substrate contacts promotes their relaxation and dissociation. Kaverina I, Krylyshkina O, Small JV (1999) J Cell Biol 146: 1033-44 Polyglycylation of tubulin is essential and affects cell motility and division in Tetrahymena thermophila. Xia L, Hai B, Gao Y, Burnette D, Thazhath R, Duan J, Bré MH, Levilliers N, Gorovsky MA, Gaertig J (2000) J Cell Biol 149: 1097-106 Nanometer targeting of microtubules to focal adhesions. Krylyshkina O, Anderson KI, Kaverina I, Upmann I, Manstein DJ, Small JV, Toomre DK (2003) J Cell Biol 161: 853-9 The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast. Guertin DA, Chang L, Irshad F, Gould KL, McCollum D (2000) EMBO J 19: 1803-15 Microtubule-regulating kinesins. Sturgill EG, Ohi R (2013) Curr Biol 23: R946-8 A-204197, a new tubulin-binding agent with antimitotic activity in tumor cell lines resistant to known microtubule inhibitors. Tahir SK, Han EK, Credo B, Jae HS, Pietenpol JA, Scatena CD, Wu-Wong JR, Frost D, Sham H, Rosenberg SH, Ng SC (2001) Cancer Res 61: 5480-5 Subversion of antimicrobial calprotectin (S100A8/S100A9 complex) in the cytoplasm of TR146 epithelial cells after invasion by Listeria monocytogenes. Zaia AA, Sappington KJ, Nisapakultorn K, Chazin WJ, Dietrich EA, Ross KF, Herzberg MC (2009) Mucosal Immunol 2: 43-53 Conserved Wat1/Pop3 WD-repeat protein of fission yeast secures genome stability through microtubule integrity and may be involved in mRNA maturation. Ochotorena IL, Hirata D, Kominami K, Potashkin J, Sahin F, Wentz-Hunter K, Gould KL, Sato K, Yoshida Y, Vardy L, Toda T (2001) J Cell Sci 114: 2911-20 Selectively increased oxidative modifications mapped to detergent-insoluble forms of Abeta and beta-III tubulin in Alzheimer's disease. Boutte AM, Woltjer RL, Zimmerman LJ, Stamer SL, Montine KS, Manno MV, Cimino PJ, Liebler DC, Montine TJ (2006) FASEB J 20: 1473-83 Contribution of hepatic organic anion-transporting polypeptides to docetaxel uptake and clearance. Lee HH, Leake BF, Teft W, Tirona RG, Kim RB, Ho RH (2015) Mol Cancer Ther 14: 994-1003 Disruption of Myc-tubulin interaction by hyperphosphorylation of c-Myc during mitosis or by constitutive hyperphosphorylation of mutant c-Myc in Burkitt's lymphoma. Niklinski J, Claassen G, Meyers C, Gregory MA, Allegra CJ, Kaye FJ, Hann SR, Zajac-Kaye M (2000) Mol Cell Biol 20: 5276-84 Removal of a single alpha-tubulin gene intron suppresses cell cycle arrest phenotypes of splicing factor mutations in Saccharomyces cerevisiae. Burns CG, Ohi R, Mehta S, O'Toole ET, Winey M, Clark TA, Sugnet CW, Ares M, Gould KL (2002) Mol Cell Biol 22: 801-15 Nuclear LC3 Associates with Slowly Diffusing Complexes that Survey the Nucleolus. Kraft LJ, Manral P, Dowler J, Kenworthy AK (2016) Traffic 17: 369-99 The Chlamydia effector chlamydial outer protein N (CopN) sequesters tubulin and prevents microtubule assembly. Archuleta TL, Du Y, English CA, Lory S, Lesser C, Ohi MD, Ohi R, Spiller BW (2011) J Biol Chem 286: 33992-8 Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function. Shankar H, Michal A, Kern RC, Kang DS, Gurevich VV, Benovic JL (2010) J Biol Chem 285: 8316-29 Visual arrestin binding to microtubules involves a distinct conformational change. Hanson SM, Francis DJ, Vishnivetskiy SA, Klug CS, Gurevich VV (2006) J Biol Chem 281: 9765-72 Mutations of tubulin glycylation sites reveal cross-talk between the C termini of alpha- and beta-tubulin and affect the ciliary matrix in Tetrahymena. Redeker V, Levilliers N, Vinolo E, Rossier J, Jaillard D, Burnette D, Gaertig J, Bré MH (2005) J Biol Chem 280: 596-606 Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules. Needleman DJ, Groen A, Ohi R, Maresca T, Mirny L, Mitchison T (2010) Mol Biol Cell 21: 323-33 Microtubule segment stabilization by RASSF1A is required for proper microtubule dynamics and Golgi integrity. Arnette C, Efimova N, Zhu X, Clark GJ, Kaverina I (2014) Mol Biol Cell 25: 800-10 Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome. Moynihan KL, Pooley R, Miller PM, Kaverina I, Bader DM (2009) Mol Biol Cell 20: 4790-803 Identification and characterization of two novel proteins affecting fission yeast gamma-tubulin complex function. Venkatram S, Tasto JJ, Feoktistova A, Jennings JL, Link AJ, Gould KL (2004) Mol Biol Cell 15: 2287-301 Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Ohi R, Sapra T, Howard J, Mitchison TJ (2004) Mol Biol Cell 15: 2895-906 Mto2p, a novel fission yeast protein required for cytoplasmic microtubule organization and anchoring of the cytokinetic actin ring. Venkatram S, Jennings JL, Link A, Gould KL (2005) Mol Biol Cell 16: 3052-63 High glucose and insulin promote O-GlcNAc modification of proteins, including alpha-tubulin. Walgren JL, Vincent TS, Schey KL, Buse MG (2003) Am J Physiol Endocrinol Metab 284: E424-34 Molecularly tailored adjuvant chemotherapy for resected non-small cell lung cancer: a time for excitement and equipoise. Azzoli CG, Park BJ, Pao W, Zakowski M, Kris MG (2008) J Thorac Oncol 3: 84-93 Identification and characterization of a new tubulin-binding tetrasubstituted brominated pyrrole. Mooberry SL, Weiderhold KN, Dakshanamurthy S, Hamel E, Banner EJ, Kharlamova A, Hempel J, Gupton JT, Brown ML (2007) Mol Pharmacol 72: 132-40 Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers. Mahoney MB, Parks AL, Ruddy DA, Tiong SY, Esengil H, Phan AC, Philandrinos P, Winter CG, Chatterjee R, Huppert K, Fisher WW, L'Archeveque L, Mapa FA, Woo W, Ellis MC, Curtis D (2006) Genetics 172: 2309-24 Microtubules regulate brush border formation. Tonucci FM, Ferretti A, Almada E, Cribb P, Vena R, Hidalgo F, Favre C, Tyska MJ, Kaverina I, Larocca MC (2018) J Cell Physiol 233: 1468-1480 Diminished taxol/GTP-stimulated tubulin polymerization in diseased region of brain from patients with late-onset or inherited Alzheimer's disease or frontotemporal dementia with parkinsonism linked to chromosome-17 but not individuals with mild cognitive impairment. Boutté AM, Neely MD, Bird TD, Montine KS, Montine TJ (2005) J Alzheimers Dis 8: 1-6 Interaction between metabotropic glutamate receptor 7 and alpha tubulin. Saugstad JA, Yang S, Pohl J, Hall RA, Conn PJ (2002) J Neurochem 80: 980-8 The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules, and modifies cellular tubulin. Neely MD, Sidell KR, Graham DG, Montine TJ (1999) J Neurochem 72: 2323-33 Structure of microtubules with reduced hydration. Comparison of results from X-ray diffraction and electron microscopy. Beese L, Stubbs G, Thomas J, Cohen C (1987) J Mol Biol 196: 575-80 Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity. Hanson SM, Cleghorn WM, Francis DJ, Vishnivetskiy SA, Raman D, Song X, Nair KS, Slepak VZ, Klug CS, Gurevich VV (2007) J Mol Biol 368: 375-87 Microtubule structure at 18 A resolution. Beese L, Stubbs G, Cohen C (1987) J Mol Biol 194: 257-64
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.