Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS (2015) J Clin Invest 125: 2646-60 Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: assessment of the roles of lipid peroxidation and selenoprotein P. Burk RF, Hill KE, Awad JA, Morrow JD, Kato T, Cockell KA, Lyons PR (1995) Hepatology 21: 561-9 Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA. Hill KE, Lloyd RS, Burk RF (1993) Proc Natl Acad Sci U S A 90: 537-41 Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. Burk RF, Hill KE (2005) Annu Rev Nutr 25: 215-35 Regulation of Selenium Metabolism and Transport. Burk RF, Hill KE (2015) Annu Rev Nutr 35: 109-34 Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease. Pitts MW, Kremer PM, Hashimoto AC, Torres DJ, Byrns CN, Williams CS, Berry MJ (2015) J Neurosci 35: 15326-38 Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects. Xia Y, Hill KE, Li P, Xu J, Zhou D, Motley AK, Wang L, Byrne DW, Burk RF (2010) Am J Clin Nutr 92: 525-31 Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration. Burk RF, Hill KE, Motley AK, Winfrey VP, Kurokawa S, Mitchell SL, Zhang W (2014) FASEB J 28: 3579-88 Maternal-fetal transfer of selenium in the mouse. Burk RF, Olson GE, Hill KE, Winfrey VP, Motley AK, Kurokawa S (2013) FASEB J 27: 3249-56 Molecular biology of selenium with implications for its metabolism. Burk RF (1991) FASEB J 5: 2274-9 Orphan selenoproteins. Burk RF, Hill KE (1999) Bioessays 21: 231-7 Isoform-specific binding of selenoprotein P to the β-propeller domain of apolipoprotein E receptor 2 mediates selenium supply. Kurokawa S, Bellinger FP, Hill KE, Burk RF, Berry MJ (2014) J Biol Chem 289: 9195-207 The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame. Hill KE, Lloyd RS, Yang JG, Read R, Burk RF (1991) J Biol Chem 266: 10050-3 Isoforms of selenoprotein P in rat plasma. Evidence for a full-length form and another form that terminates at the second UGA in the open reading frame. Himeno S, Chittum HS, Burk RF (1996) J Biol Chem 271: 15769-75 Heparin-binding histidine and lysine residues of rat selenoprotein P. Hondal RJ, Ma S, Caprioli RM, Hill KE, Burk RF (2001) J Biol Chem 276: 15823-31 Mass spectrometric characterization of full-length rat selenoprotein P and three isoforms shortened at the C terminus. Evidence that three UGA codons in the mRNA open reading frame have alternative functions of specifying selenocysteine insertion or translation termination. Ma S, Hill KE, Caprioli RM, Burk RF (2002) J Biol Chem 277: 12749-54 Deletion of selenoprotein P alters distribution of selenium in the mouse. Hill KE, Zhou J, McMahan WJ, Motley AK, Atkins JF, Gesteland RF, Burk RF (2003) J Biol Chem 278: 13640-6 Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. Hill KE, Wu S, Motley AK, Stevenson TD, Winfrey VP, Capecchi MR, Atkins JF, Burk RF (2012) J Biol Chem 287: 40414-24 Selenium and amino acid composition of selenoprotein P, the major selenoprotein in rat serum. Read R, Bellew T, Yang JG, Hill KE, Palmer IS, Burk RF (1990) J Biol Chem 265: 17899-905 A prospective study of plasma Selenoprotein P and lung cancer risk among low-income adults. Epplein M, Burk RF, Cai Q, Hargreaves MK, Blot WJ (2014) Cancer Epidemiol Biomarkers Prev 23: 1238-44 Neurodegeneration in mice resulting from loss of functional selenoprotein P or its receptor apolipoprotein E receptor 2. Valentine WM, Abel TW, Hill KE, Austin LM, Burk RF (2008) J Neuropathol Exp Neurol 67: 68-77 Genetic variation in GPX1 is associated with GPX1 activity in a comprehensive analysis of genetic variations in selenoenzyme genes and their activity and oxidative stress in humans. Takata Y, King IB, Lampe JW, Burk RF, Hill KE, Santella RM, Kristal AR, Duggan DJ, Vaughan TL, Peters U (2012) J Nutr 142: 419-26 Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P. Burk RF, Hill KE, Motley AK (2003) J Nutr 133: 1517S-20S Selenoprotein P concentration in plasma is an index of selenium status in selenium-deficient and selenium-supplemented Chinese subjects. Hill KE, Xia Y, Akesson B, Boeglin ME, Burk RF (1996) J Nutr 126: 138-45 Selenoprotein P. A selenium-rich extracellular glycoprotein. Burk RF, Hill KE (1994) J Nutr 124: 1891-7 Dietary selenium intake controls rat plasma selenoprotein P concentration. Yang JG, Hill KE, Burk RF (1989) J Nutr 119: 1010-2 Recent developments in trace element metabolism and function: newer roles of selenium in nutrition. Burk RF (1989) J Nutr 119: 1051-4 Neurological dysfunction occurs in mice with targeted deletion of the selenoprotein P gene. Hill KE, Zhou J, McMahan WJ, Motley AK, Burk RF (2004) J Nutr 134: 157-61 Selenoprotein P is required for mouse sperm development. Olson GE, Winfrey VP, Nagdas SK, Hill KE, Burk RF (2005) Biol Reprod 73: 201-11 Liver and kidney necrosis in selenium-deficient rats depleted of glutathione. Burk RF, Hill KE, Awad JA, Morrow JD, Lyons PR (1995) Lab Invest 72: 723-30 Centrilobular endothelial cell injury by diquat in the selenium-deficient rat liver. Atkinson JB, Hill KE, Burk RF (2001) Lab Invest 81: 193-200 Selenoprotein P is the major selenium transport protein in mouse milk. Hill KE, Motley AK, Winfrey VP, Burk RF (2014) PLoS One 9: e103486 Loss of selenium from selenoproteins: conversion of selenocysteine to dehydroalanine in vitro. Ma S, Caprioli RM, Hill KE, Burk RF (2003) J Am Soc Mass Spectrom 14: 593-600 Loss of activity of the selenoenzyme thioredoxin reductase causes induction of hepatic heme oxygenase-1. Mostert V, Hill KE, Burk RF (2003) FEBS Lett 541: 85-8 Mass spectrometric identification of N- and O-glycosylation sites of full-length rat selenoprotein P and determination of selenide-sulfide and disulfide linkages in the shortest isoform. Ma S, Hill KE, Burk RF, Caprioli RM (2003) Biochemistry 42: 9703-11 Multiple forms of selenoprotein P in rat plasma. Chittum HS, Himeno S, Hill KE, Burk RF (1996) Arch Biochem Biophys 325: 124-8 Mass spectrometric determination of selenenylsulfide linkages in rat selenoprotein P. Ma S, Hill KE, Burk RF, Caprioli RM (2005) J Mass Spectrom 40: 400-4 Human selenoprotein P gene maps to 5q31. Hill KE, Dasouki M, Phillips JA, Burk RF (1996) Genomics 36: 550-1 Progression of neurodegeneration and morphologic changes in the brains of juvenile mice with selenoprotein P deleted. Caito SW, Milatovic D, Hill KE, Aschner M, Burk RF, Valentine WM (2011) Brain Res 1398: 1-12 Selenoprotein P associates with endothelial cells in rat tissues. Burk RF, Hill KE, Boeglin ME, Ebner FF, Chittum HS (1997) Histochem Cell Biol 108: 11-5
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