High frequency of shared clonotypes in human B cell receptor repertoires. Soto C, Bombardi RG, Branchizio A, Kose N, Matta P, Sevy AM, Sinkovits RS, Gilchuk P, Finn JA, Crowe JE (2019) Nature 566: 398-402 Cloning and variation of ground state intestinal stem cells. Wang X, Yamamoto Y, Wilson LH, Zhang T, Howitt BE, Farrow MA, Kern F, Ning G, Hong Y, Khor CC, Chevalier B, Bertrand D, Wu L, Nagarajan N, Sylvester FA, Hyams JS, Devers T, Bronson R, Lacy DB, Ho KY, Crum CP, McKeon F, Xian W (2015) Nature 522: 173-8 Syk tyrosine kinase required for mouse viability and B-cell development. Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T (1995) Nature 378: 303-6 Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations. Payne BA, Wilson IJ, Hateley CA, Horvath R, Santibanez-Koref M, Samuels DC, Price DA, Chinnery PF (2011) Nat Genet 43: 806-10 Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K (2016) Science 351: 711-4 Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. Wen L, Pao W, Wong FS, Peng Q, Craft J, Zheng B, Kelsoe G, Dianda L, Owen MJ, Hayday AC (1996) J Exp Med 183: 2271-82 Genetics of somatic mammalian cells. III. Long-term cultivation of euploid cells from human and animal subjects. PUCK TT, CIECIURA SJ, ROBINSON A (1958) J Exp Med 108: 945-56 Gamma/delta T cell clones and natural killer cell clones mediate distinct patterns of non-major histocompatibility complex-restricted cytolysis. Fisch P, Malkovsky M, Braakman E, Sturm E, Bolhuis RL, Prieve A, Sosman JA, Lam VA, Sondel PM (1990) J Exp Med 171: 1567-79 Multiple hyperplastic polyps in the stomach: evidence for clonality and neoplastic potential. Dijkhuizen SM, Entius MM, Clement MJ, Polak MM, Van den Berg FM, Craanen ME, Slebos RJ, Offerhaus GJ (1997) Gastroenterology 112: 561-6 Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression. Fujimoto K, Beauchamp RD, Whitehead RH (2002) Gastroenterology 123: 1941-8 Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide. Alam SM, Aussedat B, Vohra Y, Meyerhoff RR, Cale EM, Walkowicz WE, Radakovich NA, Anasti K, Armand L, Parks R, Sutherland L, Scearce R, Joyce MG, Pancera M, Druz A, Georgiev IS, Von Holle T, Eaton A, Fox C, Reed SG, Louder M, Bailer RT, Morris L, Abdool-Karim SS, Cohen M, Liao HX, Montefiori DC, Park PK, Fernández-Tejada A, Wiehe K, Santra S, Kepler TB, Saunders KO, Sodroski J, Kwong PD, Mascola JR, Bonsignori M, Moody MA, Danishefsky S, Haynes BF (2017) Sci Transl Med 9: Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2. Chang BS, Minn AJ, Muchmore SW, Fesik SW, Thompson CB (1997) EMBO J 16: 968-77 Go mediates the coupling of the mu opioid receptor to adenylyl cyclase in cloned neural cells and brain. Carter BD, Medzihradsky F (1993) Proc Natl Acad Sci U S A 90: 4062-6 A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. Torre-Amione G, Beauchamp RD, Koeppen H, Park BH, Schreiber H, Moses HL, Rowley DA (1990) Proc Natl Acad Sci U S A 87: 1486-90 Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Wilson CL, Heppner KJ, Labosky PA, Hogan BL, Matrisian LM (1997) Proc Natl Acad Sci U S A 94: 1402-7 Fluorescence-activated sorting of totipotent embryonic stem cells expressing developmentally regulated lacZ fusion genes. Reddy S, Rayburn H, von Melchner H, Ruley HE (1992) Proc Natl Acad Sci U S A 89: 6721-5 Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma. Green MR, Gentles AJ, Nair RV, Irish JM, Kihira S, Liu CL, Kela I, Hopmans ES, Myklebust JH, Ji H, Plevritis SK, Levy R, Alizadeh AA (2013) Blood 121: 1604-11 Allogeneic T-cell clones able to selectively destroy Philadelphia chromosome-bearing (Ph1+) human leukemia lines can also recognize Ph1- cells from the same patient. Oettel KR, Wesly OH, Albertini MR, Hank JA, Iliopolis O, Sosman JA, Voelkerding K, Wu SQ, Clark SS, Sondel PM (1994) Blood 83: 3390-402 The relative quiescence of hematopoietic stem cells in nonhuman primates. Mahmud N, Devine SM, Weller KP, Parmar S, Sturgeon C, Nelson MC, Hewett T, Hoffman R (2001) Blood 97: 3061-8 Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Sheng H, Shao J, Morrow JD, Beauchamp RD, DuBois RN (1998) Cancer Res 58: 362-6 Autoreactive T-cells in Goodpasture's syndrome recognize the N-terminal NC1 domain on alpha 3 type IV collagen. Merkel F, Kalluri R, Marx M, Enders U, Stevanovic S, Giegerich G, Neilson EG, Rammensee HG, Hudson BG, Weber M (1996) Kidney Int 49: 1127-33 Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers. Girard N, Ostrovnaya I, Lau C, Park B, Ladanyi M, Finley D, Deshpande C, Rusch V, Orlow I, Travis WD, Pao W, Begg CB (2009) Clin Cancer Res 15: 5184-90 OPA1 mutations cause cytochrome c oxidase deficiency due to loss of wild-type mtDNA molecules. Yu-Wai-Man P, Sitarz KS, Samuels DC, Griffiths PG, Reeve AK, Bindoff LA, Horvath R, Chinnery PF (2010) Hum Mol Genet 19: 3043-52 MGSA/GRO-mediated melanocyte transformation involves induction of Ras expression. Wang D, Yang W, Du J, Devalaraja MN, Liang P, Matsumoto K, Tsubakimoto K, Endo T, Richmond A (2000) Oncogene 19: 4647-59 Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells. Sarthy AV, Morgan-Lappe SE, Zakula D, Vernetti L, Schurdak M, Packer JC, Anderson MG, Shirasawa S, Sasazuki T, Fesik SW (2007) Mol Cancer Ther 6: 269-76 T cell-intrinsic requirement for NF-kappa B induction in postdifferentiation IFN-gamma production and clonal expansion in a Th1 response. Corn RA, Aronica MA, Zhang F, Tong Y, Stanley SA, Kim SR, Stephenson L, Enerson B, McCarthy S, Mora A, Boothby M (2003) J Immunol 171: 1816-24 Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected]. Stanic AK, Shashidharamurthy R, Bezbradica JS, Matsuki N, Yoshimura Y, Miyake S, Choi EY, Schell TD, Van Kaer L, Tevethia SS, Roopenian DC, Yamamura T, Joyce S (2003) J Immunol 171: 4539-51 Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs. Li L, Sullivan BA, Aldrich CJ, Soloski MJ, Forman J, Grandea AG, Jensen PE, Van Kaer L (2004) J Immunol 173: 3707-15 Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence. Krause JC, Tsibane T, Tumpey TM, Huffman CJ, Briney BS, Smith SA, Basler CF, Crowe JE (2011) J Immunol 187: 3704-11 Immunodominance of the VH1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clones. Tian C, Luskin GK, Dischert KM, Higginbotham JN, Shepherd BE, Crowe JE (2008) J Immunol 180: 3279-88 Lymphocytes lacking I kappa B-alpha develop normally, but have selective defects in proliferation and function. Chen CL, Singh N, Yull FE, Strayhorn D, Van Kaer L, Kerr LD (2000) J Immunol 165: 5418-27 Primary gamma delta cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation. Wen L, Barber DF, Pao W, Wong FS, Owen MJ, Hayday A (1998) J Immunol 160: 1965-74 Serologic and immunochemical characterization of the specificity of four monoclonal antibodies to distinct antigenic determinants expressed on subpopulations of human Ia-like antigens. Quaranta V, Pellegrino MA, Ferrone S (1981) J Immunol 126: 548-52 VH1-46 is the dominant immunoglobulin heavy chain gene segment in rotavirus-specific memory B cells expressing the intestinal homing receptor alpha4beta7. Weitkamp JH, Kallewaard NL, Bowen AL, Lafleur BJ, Greenberg HB, Crowe JE (2005) J Immunol 174: 3454-60 Functional analysis of human T cell subsets defined by monoclonal antibodies. III. Regulation of helper factor production by T cell subsets. Thomas Y, Sosman J, Rogozinski L, Irigoyen O, Kung PC, Goldstein G, Chess L (1981) J Immunol 126: 1948-51 Functional analysis of human T cell subsets defined by monoclonal antibodies. I. Collaborative T-T interactions in the immunoregulation of B cell differentiation. Thomas Y, Sosman J, Irigoyen O, Friedman SM, Kung PC, Goldstein G, Chess L (1980) J Immunol 125: 2402-8 Costimulation of human CD4+ T cells by fibroblast growth factor-1 (acidic fibroblast growth factor). Zhao XM, Byrd VM, McKeehan WL, Reich MB, Miller GG, Thomas JW (1995) J Immunol 155: 3904-11 Immunoregulation by T cells. I. Characterization of the IEk-specific Lbd self-reactive T cell clone that helps, suppresses and contrasupresses B cell responses. Quintáns J, Suzuki H, Sosman JA, Shah PD (1986) J Immunol 136: 1974-81 The alloreactive T cell response against the class Ib molecule H2-M3 is specific for high affinity peptides. Dabhi VM, Hovik R, Van Kaer L, Lindahl KF (1998) J Immunol 161: 5171-8 Purification of immunologically functional subsets of human Ia-like antigens on a monoclonal antibody (Q5/13) immunoadsorbent. Quaranta V, Walker LE, Pellegrino MA, Ferrone S (1980) J Immunol 125: 1421-5
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