Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses. Joyce MG, Wheatley AK, Thomas PV, Chuang GY, Soto C, Bailer RT, Druz A, Georgiev IS, Gillespie RA, Kanekiyo M, Kong WP, Leung K, Narpala SN, Prabhakaran MS, Yang ES, Zhang B, Zhang Y, Asokan M, Boyington JC, Bylund T, Darko S, Lees CR, Ransier A, Shen CH, Wang L, Whittle JR, Wu X, Yassine HM, Santos C, Matsuoka Y, Tsybovsky Y, Baxa U, NISC Comparative Sequencing Program, Mullikin JC, Subbarao K, Douek DC, Graham BS, Koup RA, Ledgerwood JE, Roederer M, Shapiro L, Kwong PD, Mascola JR, McDermott AB (2016) Cell 166: 609-623 Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule. Huang Y, Park Y, Wang-Zhu Y, Larange A, Arens R, Bernardo I, Olivares-Villagómez D, Herndler-Brandstetter D, Abraham N, Grubeck-Loebenstein B, Schoenberger SP, Van Kaer L, Kronenberg M, Teitell MA, Cheroutre H (2011) Nat Immunol 12: 1086-95 Control of homeostatic proliferation by regulatory T cells. Shen S, Ding Y, Tadokoro CE, Olivares-Villagómez D, Camps-Ramírez M, Curotto de Lafaille MA, Lafaille JJ (2005) J Clin Invest 115: 3517-26 Viral acute lower respiratory infections impair CD8+ T cells through PD-1. Erickson JJ, Gilchuk P, Hastings AK, Tollefson SJ, Johnson M, Downing MB, Boyd KL, Johnson JE, Kim AS, Joyce S, Williams JV (2012) J Clin Invest 122: 2967-82 Broadly Neutralizing Antibody Mediated Clearance of Human Hepatitis C Virus Infection. Kinchen VJ, Zahid MN, Flyak AI, Soliman MG, Learn GH, Wang S, Davidson E, Doranz BJ, Ray SC, Cox AL, Crowe JE, Bjorkman PJ, Shaw GM, Bailey JR (2018) Cell Host Microbe 24: 717-730.e5 Susceptibility to allergic lung disease regulated by recall responses of dual-receptor memory T cells. Aronica MA, Swaidani S, Zhang YH, Mitchell D, Mora AL, McCarthy S, O'Neal J, Topham D, Sheller JR, Boothby M (2004) J Allergy Clin Immunol 114: 1441-8 Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease. Olivares-Villagómez D, Mendez-Fernandez YV, Parekh VV, Lalani S, Vincent TL, Cheroutre H, Van Kaer L (2008) Proc Natl Acad Sci U S A 105: 17931-6 Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors. Adeeku E, Gudapati P, Mendez-Fernandez Y, Van Kaer L, Boothby M (2008) Proc Natl Acad Sci U S A 105: 9307-12 Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment. Kordasti S, Costantini B, Seidl T, Perez Abellan P, Martinez Llordella M, McLornan D, Diggins KE, Kulasekararaj A, Benfatto C, Feng X, Smith A, Mian SA, Melchiotti R, de Rinaldis E, Ellis R, Petrov N, Povoleri GA, Chung SS, Thomas NS, Farzaneh F, Irish JM, Heck S, Young NS, Marsh JC, Mufti GJ (2016) Blood 128: 1193-205 Tolerance induction to a mammalian blood group-like carbohydrate antigen by syngeneic lymphocytes expressing the antigen, II: tolerance induction on memory B cells. Mohiuddin MM, Ogawa H, Yin DP, Galili U (2003) Blood 102: 229-36 Cellular restoration in HIV infected persons treated with abacavir and a protease inhibitor: age inversely predicts naive CD4 cell count increase. Lederman MM, McKinnis R, Kelleher D, Cutrell A, Mellors J, Neisler M, Cooney E, Haas DW, Haubrich R, Stanford J, Horton J, Landay A, Spreen W (2000) AIDS 14: 2635-42 Safety, immunogenicity, and surrogate markers of clinical efficacy for modified vaccinia Ankara as a smallpox vaccine in HIV-infected subjects. Greenberg RN, Overton ET, Haas DW, Frank I, Goldman M, von Krempelhuber A, Virgin G, Bädeker N, Vollmar J, Chaplin P (2013) J Infect Dis 207: 749-58 Immune responses to pertussis vaccines and disease. Edwards KM, Berbers GA (2014) J Infect Dis 209 Suppl 1: S10-5 Restricted V gene repertoire in the secondary response to insulin in young BALB/c mice. Tikhomirov OYu , Thomas JW (1997) J Immunol 158: 4292-300 STAT4 and T-bet are required for the plasticity of IFN-γ expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation. Williams CL, Schilling MM, Cho SH, Lee K, Wei M, Aditi , Boothby M (2013) J Immunol 191: 678-87 IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity. Sikora AG, Jaffarzad N, Hailemichael Y, Gelbard A, Stonier SW, Schluns KS, Frasca L, Lou Y, Liu C, Andersson HA, Hwu P, Overwijk WW (2009) J Immunol 182: 7398-407 Immunodominance of the VH1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clones. Tian C, Luskin GK, Dischert KM, Higginbotham JN, Shepherd BE, Crowe JE (2008) J Immunol 180: 3279-88 T cell-independent response to Brucella-insulin identifies a preimmune repertoire for insulin. Thomas JW, Kralick PM, Ewulonu UK (1997) J Immunol 159: 2334-41 Regulatory defects in Cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells. Yi Y, McNerney M, Datta SK (2000) J Immunol 165: 6627-34 Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes. Wang T, Chen L, Ahmed E, Ma L, Yin D, Zhou P, Shen J, Xu H, Wang CR, Alegre ML, Chong AS (2008) J Immunol 180: 5991-9 Immunoregulation by T cells. I. Characterization of the IEk-specific Lbd self-reactive T cell clone that helps, suppresses and contrasupresses B cell responses. Quintáns J, Suzuki H, Sosman JA, Shah PD (1986) J Immunol 136: 1974-81 Differential regulation of granzyme and perforin in effector and memory T cells following smallpox immunization. Rock MT, Yoder SM, Wright PF, Talbot TR, Edwards KM, Crowe JE (2005) J Immunol 174: 3757-64 VH1-46 is the dominant immunoglobulin heavy chain gene segment in rotavirus-specific memory B cells expressing the intestinal homing receptor alpha4beta7. Weitkamp JH, Kallewaard NL, Bowen AL, Lafleur BJ, Greenberg HB, Crowe JE (2005) J Immunol 174: 3454-60 Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells. Medeiros AI, Sá-Nunes A, Turato WM, Secatto A, Frantz FG, Sorgi CA, Serezani CH, Deepe GS, Faccioli LH (2008) J Immunol 181: 8544-51 B Cell-Intrinsic mTORC1 Promotes Germinal Center-Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity. Raybuck AL, Cho SH, Li J, Rogers MC, Lee K, Williams CL, Shlomchik M, Thomas JW, Chen J, Williams JV, Boothby MR (2018) J Immunol 200: 2627-2639 Links between Immunologic Memory and Metabolic Cycling. Cottam MA, Itani HA, Beasley AA, Hasty AH (2018) J Immunol 200: 3681-3689 Mapping the Human Memory B Cell and Serum Neutralizing Antibody Responses to Dengue Virus Serotype 4 Infection and Vaccination. Nivarthi UK, Kose N, Sapparapu G, Widman D, Gallichotte E, Pfaff JM, Doranz BJ, Weiskopf D, Sette A, Durbin AP, Whitehead SS, Baric R, Crowe JE, de Silva AM (2017) J Virol 91: Innate and virtual memory T cells in man. Van Kaer L (2015) Eur J Immunol 45: 1916-20 Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation. Chen W, Li L, Brod T, Saeed O, Thabet S, Jansen T, Dikalov S, Weyand C, Goronzy J, Harrison DG (2011) J Biol Chem 286: 13846-51 Induction of immune tolerance to a transplantation carbohydrate antigen by gene therapy with autologous lymphocytes transduced with adenovirus containing the corresponding glycosyltransferase gene. Ogawa H, Yin DP, Galili U (2004) Gene Ther 11: 292-301 Mycobacterium tuberculosis in chemokine receptor 2-deficient mice: influence of dose on disease progression. Scott HM, Flynn JL (2002) Infect Immun 70: 5946-54 Antibody-mediated accommodation of heart grafts expressing an incompatible carbohydrate antigen. Mohiuddin MM, Ogawa H, Yin DP, Shen J, Galili U (2003) Transplantation 75: 258-62 Vulnerability of allografts to rejection by MHC class II-restricted T-cell receptor transgenic mice. Lee MK, Huang X, Jarrett BP, Moore DJ, Desai NM, Moh Lian M, Markmann JW, Deng S, Frank A, Singer A, Velidedeoglu E, Caton AJ, Markmann AJ (2003) Transplantation 75: 1415-22 Mouse-heart grafts expressing an incompatible carbohydrate antigen. II. Transition from accommodation to tolerance. Ogawa H, Mohiuddin MM, Yin DP, Shen J, Chong AS, Galili U (2004) Transplantation 77: 366-73 High-throughput antibody sequencing reveals genetic evidence of global regulation of the naïve and memory repertoires that extends across individuals. Briney BS, Willis JR, McKinney BA, Crowe JE (2012) Genes Immun 13: 469-73 Predominant usage of the proximal poly(A) site in alpha mRNAs is not intrinsic to the 3' termini. Coyle JH, Borinstein SC, Woodward EO, Lebman DA (1998) Int Immunol 10: 669-78 Transcriptional reprogramming during T helper cell differentiation. Aune TM (2001) Immunol Res 23: 193-204 IL-4 signaling, gene transcription regulation, and the control of effector T cells. Boothby M, Mora AL, Aronica MA, Youn J, Sheller JR, Goenka S, Stephenson L (2001) Immunol Res 23: 179-91 Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naïve and memory B cells. Tian C, Luskin GK, Dischert KM, Higginbotham JN, Shepherd BE, Crowe JE (2007) Mol Immunol 44: 2173-83 T lymphocyte subset abnormalities in the blood and lung in pulmonary arterial hypertension. Austin ED, Rock MT, Mosse CA, Vnencak-Jones CL, Yoder SM, Robbins IM, Loyd JE, Meyrick BO (2010) Respir Med 104: 454-62
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.