Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Bierie B, Moses HL (2006) Nat Rev Cancer 6: 506-20 Mapping normal and cancer cell signalling networks: towards single-cell proteomics. Irish JM, Kotecha N, Nolan GP (2006) Nat Rev Cancer 6: 146-55 Reciprocal regulation between natural killer cells and autoreactive T cells. Shi FD, Van Kaer L (2006) Nat Rev Immunol 6: 751-60 Organ-specific features of natural killer cells. Shi FD, Ljunggren HG, La Cava A, Van Kaer L (2011) Nat Rev Immunol 11: 658-71 Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate. Yamada T, Pfaff SL, Edlund T, Jessell TM (1993) Cell 73: 673-86 Boning up on ephrin signaling. Mundy GR, Elefteriou F (2006) Cell 126: 441-3 Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons. Meltzer S, Yadav S, Lee J, Soba P, Younger SH, Jin P, Zhang W, Parrish J, Jan LY, Jan YN (2016) Neuron 89: 741-55 RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion. Ding J, Guzman JN, Tkatch T, Chen S, Goldberg JA, Ebert PJ, Levitt P, Wilson CJ, Hamm HE, Surmeier DJ (2006) Nat Neurosci 9: 832-42 Molecular cues to implantation. Dey SK, Lim H, Das SK, Reese J, Paria BC, Daikoku T, Wang H (2004) Endocr Rev 25: 341-73 Targeting tumor cell motility to prevent metastasis. Palmer TD, Ashby WJ, Lewis JD, Zijlstra A (2011) Adv Drug Deliv Rev 63: 568-81 Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Means AL, Ray KC, Singh AB, Washington MK, Whitehead RH, Harris RC, Wright CV, Coffey RJ, Leach SD (2003) Gastroenterology 124: 1020-36 Direct contact between sympathetic neurons and rat cardiac myocytes in vitro increases expression of functional calcium channels. Ogawa S, Barnett JV, Sen L, Galper JB, Smith TW, Marsh JD (1992) J Clin Invest 89: 1085-93 Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice. Matsusaka T, Katori H, Inagami T, Fogo A, Ichikawa I (1999) J Clin Invest 103: 1451-8 Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification. Hong CC, Kume T, Peterson RT (2008) Circ Res 103: 573-9 Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Frank DB, Abtahi A, Yamaguchi DJ, Manning S, Shyr Y, Pozzi A, Baldwin HS, Johnson JE, de Caestecker MP (2005) Circ Res 97: 496-504 Only our patients know for sure. Baldwin HS (2004) Circ Res 94: 1401-2 A matrix metalloproteinase mediates long-distance attenuation of stem cell proliferation. Wang X, Page-McCaw A (2014) J Cell Biol 206: 923-36 Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. Erdogan B, Ao M, White LM, Means AL, Brewer BM, Yang L, Washington MK, Shi C, Franco OE, Weaver AM, Hayward SW, Li D, Webb DJ (2017) J Cell Biol 216: 3799-3816 Comparative and functional characterization of intragenic tandem repeats in 10 Aspergillus genomes. Gibbons JG, Rokas A (2009) Mol Biol Evol 26: 591-602 Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth. Wang D, Fu L, Ning W, Guo L, Sun X, Dey SK, Chaturvedi R, Wilson KT, DuBois RN (2014) Proc Natl Acad Sci U S A 111: 7084-9 Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, Proby CM, Leigh IM, Collisson EA, Gordon PB, Jakkula L, Pennypacker S, Zou Y, Sharma M, North JP, Vemula SS, Mauro TM, Neuhaus IM, Leboit PE, Hur JS, Park K, Huh N, Kwok PY, Arron ST, Massion PP, Bale AE, Haussler D, Cleaver JE, Gray JW, Spellman PT, South AP, Aster JC, Blacklow SC, Cho RJ (2011) Proc Natl Acad Sci U S A 108: 17761-6 Platelet interactions with fibronectin: divalent cation-independent platelet adhesion to the gelatin-binding domain of fibronectin. Winters KJ, Walsh JJ, Rubin BG, Santoro SA (1993) Blood 81: 1778-86 Integrins in kidney disease. Pozzi A, Zent R (2013) J Am Soc Nephrol 24: 1034-9 Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics. Benninger RK, Piston DW (2014) Trends Endocrinol Metab 25: 399-406 Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression. Palmer TD, Martínez CH, Vasquez C, Hebron KE, Jones-Paris C, Arnold SA, Chan SM, Chalasani V, Gomez-Lemus JA, Williams AK, Chin JL, Giannico GA, Ketova T, Lewis JD, Zijlstra A (2014) Cancer Res 74: 173-87 Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Ao M, Franco OE, Park D, Raman D, Williams K, Hayward SW (2007) Cancer Res 67: 4244-53 Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the down-regulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cells. Ueda Y, Neel NF, Schutyser E, Raman D, Richmond A (2006) Cancer Res 66: 5665-75 Malignant transformation in a nontumorigenic human prostatic epithelial cell line. Hayward SW, Wang Y, Cao M, Hom YK, Zhang B, Grossfeld GD, Sudilovsky D, Cunha GR (2001) Cancer Res 61: 8135-42 Tumor microenvironment complexity: emerging roles in cancer therapy. Swartz MA, Iida N, Roberts EW, Sangaletti S, Wong MH, Yull FE, Coussens LM, DeClerck YA (2012) Cancer Res 72: 2473-80 The role of transforming growth factor-beta-mediated tumor-stroma interactions in prostate cancer progression: an integrative approach. Basanta D, Strand DW, Lukner RB, Franco OE, Cliffel DE, Ayala GE, Hayward SW, Anderson AR (2009) Cancer Res 69: 7111-20 Regulation of Helicobacter pylori cagA expression in response to salt. Loh JT, Torres VJ, Cover TL (2007) Cancer Res 67: 4709-15 Preconditioned endothelial progenitor cells reduce formation of melanoma metastases through SPARC-driven cell-cell interactions and endocytosis. Defresne F, Bouzin C, Grandjean M, Dieu M, Raes M, Hatzopoulos AK, Kupatt C, Feron O (2011) Cancer Res 71: 4748-57 Microenvironmental independence associated with tumor progression. Anderson AR, Hassanein M, Branch KM, Lu J, Lobdell NA, Maier J, Basanta D, Weidow B, Narasanna A, Arteaga CL, Reynolds AB, Quaranta V, Estrada L, Weaver AM (2009) Cancer Res 69: 8797-806 The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1. Almohazey D, Lo YH, Vossler CV, Simmons AJ, Hsieh JJ, Bucar EB, Schumacher MA, Hamilton KE, Lau KS, Shroyer NF, Frey MR (2017) Cell Death Differ 24: 855-865 Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease. Haase VH (2009) Kidney Int 76: 492-9 Progression of chronic kidney disease: too much cellular talk causes damage. Gewin L, Zent R, Pozzi A (2017) Kidney Int 91: 552-560 The role of the microenvironment and intercellular cross-talk in tumor angiogenesis. Jung YD, Ahmad SA, Liu W, Reinmuth N, Parikh A, Stoeltzing O, Fan F, Ellis LM (2002) Semin Cancer Biol 12: 105-12 Microcircuitry for two types of achromatic ganglion cell in primate fovea. Calkins DJ, Sterling P (2007) J Neurosci 27: 2646-53 Modulation of electrical synaptic transmission in zebrafish retinal horizontal cells. McMahon DG (1994) J Neurosci 14: 1722-34 Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts. Hutcheson JD, Chen J, Sewell-Loftin MK, Ryzhova LM, Fisher CI, Su YR, Merryman WD (2013) Arterioscler Thromb Vasc Biol 33: 114-20
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.