Keyword Connections

•  Barbara Fingleton
•  Christopher Williams

•  Damian Maseda
•  Pandu Gangula

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Publications

• Increased prostaglandin production in ulcerative colitis.
  Gould SR, Brash AR, Conolly ME
  (1977) Lancet 2: 98
• TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
  Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L, Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C, Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK, Markowitz SD
  (2015) Science 348: aaa2340
• Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
  Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, Lozano G, Pikarsky E, Forshew T, Rosenfeld N, Rozenfeld N, Harpaz N, Itzkowitz S, Harris CC, Rotter V, Gorgoulis VG, Oren M
  (2013) Cancer Cell 23: 634-46
• Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans.
  An G, Wei B, Xia B, McDaniel JM, Ju T, Cummings RD, Braun J, Xia L
  (2007) J Exp Med 204: 1417-29
• Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease.
  Biancheri P, Brezski RJ, Di Sabatino A, Greenplate AR, Soring KL, Corazza GR, Kok KB, Rovedatti L, Vossenkämper A, Ahmad N, Snoek SA, Vermeire S, Rutgeerts P, Jordan RE, MacDonald TT
  (2015) Gastroenterology 149: 1564-1574.e3
• KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production.
  Goettel JA, Scott Algood HM, Olivares-Villagómez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk DB
  (2011) Gastroenterology 140: 265-74
• Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB.
  Edelblum KL, Washington MK, Koyama T, Robine S, Baccarini M, Polk DB
  (2008) Gastroenterology 135: 539-51
• The effect of folic acid supplementation on the risk for cancer or dysplasia in ulcerative colitis.
  Lashner BA, Provencher KS, Seidner DL, Knesebeck A, Brzezinski A
  (1997) Gastroenterology 112: 29-32
• Tumor Necrosis Factor Receptor 2 Restricts the Pathogenicity of CD8(+) T Cells in Mice With Colitis.
  Punit S, Dubé PE, Liu CY, Girish N, Washington MK, Polk DB
  (2015) Gastroenterology 149: 993-1005.e2
• Deletion of Mtgr1 sensitizes the colonic epithelium to dextran sodium sulfate-induced colitis.
  Martinez JA, Williams CS, Amann JM, Ellis TC, Moreno-Miralles I, Washington MK, Gregoli P, Hiebert SW
  (2006) Gastroenterology 131: 579-88
• Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naive Pediatric Patients.
  Rosen MJ, Karns R, Vallance JE, Bezold R, Waddell A, Collins MH, Haberman Y, Minar P, Baldassano RN, Hyams JS, Baker SS, Kellermayer R, Noe JD, Griffiths AM, Rosh JR, Crandall WV, Heyman MB, Mack DR, Kappelman MD, Markowitz J, Moulton DE, Leleiko NS, Walters TD, Kugathasan S, Wilson KT, Hogan SP, Denson LA
  (2017) Gastroenterology 152: 1345-1357.e7
• Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.
  Shah YM, Ito S, Morimura K, Chen C, Yim SH, Haase VH, Gonzalez FJ
  (2008) Gastroenterology 134: 2036-48, 2048.e1-3
• Epidermal growth factor receptor inhibits colitis-associated cancer in mice.
  Dubé PE, Yan F, Punit S, Girish N, McElroy SJ, Washington MK, Polk DB
  (2012) J Clin Invest 122: 2780-92
• Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage.
  Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS
  (2015) J Clin Invest 125: 2646-60
• Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.
  Karhausen J, Furuta GT, Tomaszewski JE, Johnson RS, Colgan SP, Haase VH
  (2004) J Clin Invest 114: 1098-106
• Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.
  Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, Chaturvedi R, Peek RM, Wilson KT, Polk DB
  (2011) J Clin Invest 121: 2242-53
• Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling.
  Pope JL, Bhat AA, Sharma A, Ahmad R, Krishnan M, Washington MK, Beauchamp RD, Singh AB, Dhawan P
  (2014) Gut 63: 622-34
• MTG16 contributes to colonic epithelial integrity in experimental colitis.
  Williams CS, Bradley AM, Chaturvedi R, Singh K, Piazuelo MB, Chen X, McDonough EM, Schwartz DA, Brown CT, Allaman MM, Coburn LA, Horst SN, Beaulieu DB, Choksi YA, Washington MK, Williams AD, Fisher MA, Zinkel SS, Peek RM, Wilson KT, Hiebert SW
  (2013) Gut 62: 1446-55
• BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.
  Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS
  (2017) Gut 66: 852-862
• Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications.
  Hardbower DM, Asim M, Luis PB, Singh K, Barry DP, Yang C, Steeves MA, Cleveland JL, Schneider C, Piazuelo MB, Gobert AP, Wilson KT
  (2017) Proc Natl Acad Sci U S A 114: E751-E760
• Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease.
  Olivares-Villagómez D, Mendez-Fernandez YV, Parekh VV, Lalani S, Vincent TL, Cheroutre H, Van Kaer L
  (2008) Proc Natl Acad Sci U S A 105: 17931-6
• Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth.
  Wang D, Fu L, Ning W, Guo L, Sun X, Dey SK, Chaturvedi R, Wilson KT, DuBois RN
  (2014) Proc Natl Acad Sci U S A 111: 7084-9
• Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production.
  Leonard JP, Sherman ML, Fisher GL, Buchanan LJ, Larsen G, Atkins MB, Sosman JA, Dutcher JP, Vogelzang NJ, Ryan JL
  (1997) Blood 90: 2541-8
• MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model.
  Barrett CW, Fingleton B, Williams A, Ning W, Fischer MA, Washington MK, Chaturvedi R, Wilson KT, Hiebert SW, Williams CS
  (2011) Cancer Res 71: 1302-12
• Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma.
  Barrett CW, Ning W, Chen X, Smith JJ, Washington MK, Hill KE, Coburn LA, Peek RM, Chaturvedi R, Wilson KT, Burk RF, Williams CS
  (2013) Cancer Res 73: 1245-55
• Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses.
  Singh K, Coburn LA, Asim M, Barry DP, Allaman MM, Shi C, Washington MK, Luis PB, Schneider C, Delgado AG, Piazuelo MB, Cleveland JL, Gobert AP, Wilson KT
  (2018) Cancer Res 78: 4303-4315
• Upregulated claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner.
  Gowrikumar S, Ahmad R, Uppada SB, Washington MK, Shi C, Singh AB, Dhawan P
  (2019) Oncogene 38: 5321-5337
• Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma.
  Short SP, Barrett CW, Stengel KR, Revetta FL, Choksi YA, Coburn LA, Lintel MK, McDonough EM, Washington MK, Wilson KT, Prokhortchouk E, Chen X, Hiebert SW, Reynolds AB, Williams CS
  (2019) Oncogene 38: 5091-5106
• EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis.
  Hardbower DM, Coburn LA, Asim M, Singh K, Sierra JC, Barry DP, Gobert AP, Piazuelo MB, Washington MK, Wilson KT
  (2017) Oncogene 36: 3807-3819
• Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer.
  Wang C, Gong G, Sheh A, Muthupalani S, Bryant EM, Puglisi DA, Holcombe H, Conaway EA, Parry NAP, Bakthavatchalu V, Short SP, Williams CS, Wogan GN, Tannenbaum SR, Fox JG, Horwitz BH
  (2017) Mucosal Immunol 10: 1504-1517
• BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability.
  Choksi YA, Reddy VK, Singh K, Barrett CW, Short SP, Parang B, Keating CE, Thompson JJ, Verriere TG, Brown RE, Piazuelo MB, Bader DM, Washington MK, Mittal MK, Brand T, Gobert AP, Coburn LA, Wilson KT, Williams CS
  (2018) Mucosal Immunol 11: 1363-1374
• Neonatal colonization of mice with LGG promotes intestinal development and decreases susceptibility to colitis in adulthood.
  Yan F, Liu L, Cao H, Moore DJ, Washington MK, Wang B, Peek RM, Acra SA, Polk DB
  (2017) Mucosal Immunol 10: 117-127
• Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis.
  Ahmad R, Chaturvedi R, Olivares-Villagómez D, Habib T, Asim M, Shivesh P, Polk DB, Wilson KT, Washington MK, Van Kaer L, Dhawan P, Singh AB
  (2014) Mucosal Immunol 7: 1340-53
• Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in mice.
  Maseda D, Candando KM, Smith SH, Kalampokis I, Weaver CT, Plevy SE, Poe JC, Tedder TF
  (2013) J Immunol 191: 2780-2795
• Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis.
  Lu N, Wang L, Cao H, Liu L, Van Kaer L, Washington MK, Rosen MJ, Dubé PE, Wilson KT, Ren X, Hao X, Polk DB, Yan F
  (2014) J Immunol 192: 1013-23
• Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34.
  Parekh VV, Wu L, Boyd KL, Williams JA, Gaddy JA, Olivares-Villagómez D, Cover TL, Zong WX, Zhang J, Van Kaer L
  (2013) J Immunol 190: 5086-101
• Protective role of arginase in a mouse model of colitis.
  Gobert AP, Cheng Y, Akhtar M, Mersey BD, Blumberg DR, Cross RK, Chaturvedi R, Drachenberg CB, Boucher JL, Hacker A, Casero RA, Wilson KT
  (2004) J Immunol 173: 2109-17