Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, Chaturvedi R, Peek RM, Wilson KT, Polk DB (2011) J Clin Invest 121: 2242-53 Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice. Lenferink AE, Simpson JF, Shawver LK, Coffey RJ, Forbes JT, Arteaga CL (2000) Proc Natl Acad Sci U S A 97: 9609-14 Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. Kurokawa H, Lenferink AE, Simpson JF, Pisacane PI, Sliwkowski MX, Forbes JT, Arteaga CL (2000) Cancer Res 60: 5887-94 Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers. Haruki N, Kawaguchi KS, Eichenberger S, Massion PP, Olson S, Gonzalez A, Carbone DP, Dang TP (2005) Cancer Res 65: 3555-61 ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways. Lenferink AE, Busse D, Flanagan WM, Yakes FM, Arteaga CL (2001) Cancer Res 61: 6583-91 Regulation of c-myc stability by selective stress conditions and by MEKK1 requires aa 127-189 of c-myc. Alarcon-Vargas D, Tansey WP, Ronai Z (2002) Oncogene 21: 4384-91 Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal-regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptor. Peavy RD, Chang MS, Sanders-Bush E, Conn PJ (2001) J Neurosci 21: 9619-28 Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis. Lu N, Wang L, Cao H, Liu L, Van Kaer L, Washington MK, Rosen MJ, Dubé PE, Wilson KT, Ren X, Hao X, Polk DB, Yan F (2014) J Immunol 192: 1013-23 Regulated intramembrane cleavage of the EGF receptor. Liao HJ, Carpenter G (2012) Traffic 13: 1106-12 Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity. Busse D, Doughty RS, Ramsey TT, Russell WE, Price JO, Flanagan WM, Shawver LK, Arteaga CL (2000) J Biol Chem 275: 6987-95 Unliganded epidermal growth factor receptor dimerization induced by direct interaction of quinazolines with the ATP binding site. Arteaga CL, Ramsey TT, Shawver LK, Guyer CA (1997) J Biol Chem 272: 23247-54 Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species. Samarakoon R, Dobberfuhl AD, Cooley C, Overstreet JM, Patel S, Goldschmeding R, Meldrum KK, Higgins PJ (2013) Cell Signal 25: 2198-209 Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis. Bullard LE, Qi X, Penn JS (2003) Invest Ophthalmol Vis Sci 44: 1722-31 ErbB4 localization to cardiac myocyte nuclei, and its role in myocyte DNA damage response. Icli B, Bharti A, Pentassuglia L, Peng X, Sawyer DB (2012) Biochem Biophys Res Commun 418: 116-21 Tyrosine kinase inhibition affects type 1 angiotensin II receptor internalization. Becker BN, Kondo S, Chen JK, Harris RC (1999) J Recept Signal Transduct Res 19: 975-93
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