Keyword Connections

•  Carlos Arteaga
•  David Robertson
•  Douglas Mortlock
•  Jennifer Skelton

•  Lance Prince
•  Linda Gower
•  Mark de Caestecker
•  Maureen Gannon

•  Stacey Huppert
•  Thomas Andl
•  Timothy Blackwell
•  Vsevolod Gurevich

Resources

• B6.Cg-Tg(Alb-Cre)21Mgn/J
• B6.Cg-Tg(Ins2-cre)25Mgn/J
• B6.Cg-Tg(Ins2-cre)25Mgn/J
• B6;SJL-TgN(ACTFLPe)9205DMY
• pAlb.CRE.GH
• pAlb.GH
• pRIP.Cre.GH
• Pronuclear or Cytoplasmic Zygote Microinjections

Communities

• de Caestecker Lab
• Maureen Gannon Lab
• Mortlock Lab
• Vanderbilt Genome Editing Resource
• Vanderbilt Genome Editing Resource Advisory Committee
• Vanderbilt Mouse Metabolic Phenotyping Center

Publications

• Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
  Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, Southam L, Cox RD, Lathrop GM, Boriraj VV, Chen X, Cox NJ, Oda Y, Yano H, Le Beau MM, Yamada S, Nishigori H, Takeda J, Fajans SS, Hattersley AT, Iwasaki N, Hansen T, Pedersen O, Polonsky KS, Bell GI
  (1996) Nature 384: 455-8
• Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice.
  Breuer M, Slebos R, Verbeek S, van Lohuizen M, Wientjens E, Berns A
  (1989) Nature 340: 61-3
• Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
  Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR
  (2017) Nature 545: 243-247
• Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation.
  Dor Y, Brown J, Martinez OI, Melton DA
  (2004) Nature 429: 41-6
• Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.
  Silva JP, Köhler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG
  (2000) Nat Genet 26: 336-40
• High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP.
  Rodríguez CI, Buchholz F, Galloway J, Sequerra R, Kasper J, Ayala R, Stewart AF, Dymecki SM
  (2000) Nat Genet 25: 139-40
• Generation of functional insulin-producing cells in the gut by Foxo1 ablation.
  Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D
  (2012) Nat Genet 44: 406-12, S1
• Spatiotemporal regulation of endothelin receptor-B by SOX10 in neural crest-derived enteric neuron precursors.
  Zhu L, Lee HO, Jordan CS, Cantrell VA, Southard-Smith EM, Shin MK
  (2004) Nat Genet 36: 732-7
• Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes.
  Bowman AB, Lam YC, Jafar-Nejad P, Chen HK, Richman R, Samaco RC, Fryer JD, Kahle JJ, Orr HT, Zoghbi HY
  (2007) Nat Genet 39: 373-9
• Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.
  Nakae J, Biggs WH, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D
  (2002) Nat Genet 32: 245-53
• Wnt-beta-catenin signaling initiates taste papilla development.
  Liu F, Thirumangalathu S, Gallant NM, Yang SH, Stoick-Cooper CL, Reddy ST, Andl T, Taketo MM, Dlugosz AA, Moon RT, Barlow LA, Millar SE
  (2007) Nat Genet 39: 106-12
• A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes.
  Cree LM, Samuels DC, de Sousa Lopes SC, Rajasimha HK, Wonnapinij P, Mann JR, Dahl HH, Chinnery PF
  (2008) Nat Genet 40: 249-54
• Organ-specific features of natural killer cells.
  Shi FD, Ljunggren HG, La Cava A, Van Kaer L
  (2011) Nat Rev Immunol 11: 658-71
• Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase.
  Jo D, Nashabi A, Doxsee C, Lin Q, Unutmaz D, Chen J, Ruley HE
  (2001) Nat Biotechnol 19: 929-33
• Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
  Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR
  (1999) Cell 96: 329-39
• Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.
  Lau KS, Partridge EA, Grigorian A, Silvescu CI, Reinhold VN, Demetriou M, Dennis JW
  (2007) Cell 129: 123-34
• Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin.
  Winder DG, Mansuy IM, Osman M, Moallem TM, Kandel ER
  (1998) Cell 92: 25-37
• From silencing to gene expression: real-time analysis in single cells.
  Janicki SM, Tsukamoto T, Salghetti SE, Tansey WP, Sachidanandam R, Prasanth KV, Ried T, Shav-Tal Y, Bertrand E, Singer RH, Spector DL
  (2004) Cell 116: 683-98
• Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides.
  Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ, Cone RD
  (1997) Cell 91: 789-98
• Evidence for a differential avidity model of T cell selection in the thymus.
  Ashton-Rickardt PG, Bandeira A, Delaney JR, Van Kaer L, Pircher HP, Zinkernagel RM, Tonegawa S
  (1994) Cell 76: 651-63
• Epidermal sensing of oxygen is essential for systemic hypoxic response.
  Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS
  (2008) Cell 133: 223-34
• Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin.
  Malleret G, Haditsch U, Genoux D, Jones MW, Bliss TV, Vanhoose AM, Weitlauf C, Kandel ER, Winder DG, Mansuy IM
  (2001) Cell 104: 675-86
• p120-catenin mediates inflammatory responses in the skin.
  Perez-Moreno M, Davis MA, Wong E, Pasolli HA, Reynolds AB, Fuchs E
  (2006) Cell 124: 631-44
• Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.
  Johnson MO, Wolf MM, Madden MZ, Andrejeva G, Sugiura A, Contreras DC, Maseda D, Liberti MV, Paz K, Kishton RJ, Johnson ME, de Cubas AA, Wu P, Li G, Zhang Y, Newcomb DC, Wells AD, Restifo NP, Rathmell WK, Locasale JW, Davila ML, Blazar BR, Rathmell JC
  (2018) Cell 175: 1780-1795.e19
• Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
  Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP
  (2012) Cell 149: 49-62
• CRISPR-Cas9 knockin mice for genome editing and cancer modeling.
  Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F
  (2014) Cell 159: 440-55
• TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells.
  Van Kaer L, Ashton-Rickardt PG, Ploegh HL, Tonegawa S
  (1992) Cell 71: 1205-14
• Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice.
  Matsui Y, Halter SA, Holt JT, Hogan BL, Coffey RJ
  (1990) Cell 61: 1147-55
• Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals.
  Fox MA, Sanes JR, Borza DB, Eswarakumar VP, Fässler R, Hudson BG, John SW, Ninomiya Y, Pedchenko V, Pfaff SL, Rheault MN, Sado Y, Segal Y, Werle MJ, Umemori H
  (2007) Cell 129: 179-93
• Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.
  Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS
  (2005) Cell 120: 701-13
• The protein kinase IKKepsilon regulates energy balance in obese mice.
  Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR
  (2009) Cell 138: 961-75
• Transgenic HLA-DR alpha faithfully reconstitutes IE-controlled immune functions and induces cross-tolerance to E alpha in E alpha 0 mutant mice.
  Lawrance SK, Karlsson L, Price J, Quaranta V, Ron Y, Sprent J, Peterson PA
  (1989) Cell 58: 583-94
• TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia.
  Bhowmick NA, Chytil A, Plieth D, Gorska AE, Dumont N, Shappell S, Washington MK, Neilson EG, Moses HL
  (2004) Science 303: 848-51
• Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.
  Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH
  (2006) Science 311: 1774-5
• Autonomic nerve development contributes to prostate cancer progression.
  Magnon C, Hall SJ, Lin J, Xue X, Gerber L, Freedland SJ, Frenette PS
  (2013) Science 341: 1236361
• Self-organizing and stochastic behaviors during the regeneration of hair stem cells.
  Plikus MV, Baker RE, Chen CC, Fare C, de la Cruz D, Andl T, Maini PK, Millar SE, Widelitz R, Chuong CM
  (2011) Science 332: 586-9