Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody. Kong R, Xu K, Zhou T, Acharya P, Lemmin T, Liu K, Ozorowski G, Soto C, Taft JD, Bailer RT, Cale EM, Chen L, Choi CW, Chuang GY, Doria-Rose NA, Druz A, Georgiev IS, Gorman J, Huang J, Joyce MG, Louder MK, Ma X, McKee K, O'Dell S, Pancera M, Yang Y, Blanchard SC, Mothes W, Burton DR, Koff WC, Connors M, Ward AB, Kwong PD, Mascola JR (2016) Science 352: 828-33 Progression of respiratory syncytial virus infection monitored by fluorescent quantum dot probes. Bentzen EL, House F, Utley TJ, Crowe JE, Wright DW (2005) Nano Lett 5: 591-5 Repurposing staples for viruses: applying peptide design to RSV prophylaxis. Katen SP, Dermody TS (2014) J Clin Invest 124: 1889-91 The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. King LB, Fusco ML, Flyak AI, Ilinykh PA, Huang K, Gunn B, Kirchdoerfer RN, Hastie KM, Sangha AK, Meiler J, Alter G, Bukreyev A, Crowe JE, Saphire EO (2018) Cell Host Microbe 23: 101-109.e4 Expression at the cell surface of biologically active fusion and hemagglutinin/neuraminidase proteins of the paramyxovirus simian virus 5 from cloned cDNA. Paterson RG, Hiebert SW, Lamb RA (1985) Proc Natl Acad Sci U S A 82: 7520-4 Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein. Mousa JJ, Sauer MF, Sevy AM, Finn JA, Bates JT, Alvarado G, King HG, Loerinc LB, Fong RH, Doranz BJ, Correia BE, Kalyuzhniy O, Wen X, Jardetzky TS, Schief WR, Ohi MD, Meiler J, Crowe JE (2016) Proc Natl Acad Sci U S A 113: E6849-E6858 Human monoclonal Fab fragments derived from a combinatorial library bind to respiratory syncytial virus F glycoprotein and neutralize infectivity. Barbas CF, Crowe JE, Cababa D, Jones TM, Zebedee SL, Murphy BR, Chanock RM, Burton DR (1992) Proc Natl Acad Sci U S A 89: 10164-8 Integrin alphavbeta1 promotes infection by human metapneumovirus. Cseke G, Maginnis MS, Cox RG, Tollefson SJ, Podsiad AB, Wright DW, Dermody TS, Williams JV (2009) Proc Natl Acad Sci U S A 106: 1566-71 The impact of viral genotype on pathogenesis and disease severity: respiratory syncytial virus and human rhinoviruses. Moore ML, Stokes KL, Hartert TV (2013) Curr Opin Immunol 25: 761-8 A critical phenylalanine residue in the respiratory syncytial virus fusion protein cytoplasmic tail mediates assembly of internal viral proteins into viral filaments and particles. Shaikh FY, Cox RG, Lifland AW, Hotard AL, Williams JV, Moore ML, Santangelo PJ, Crowe JE (2012) MBio 3: Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency. Bates JT, Keefer CJ, Utley TJ, Correia BE, Schief WR, Crowe JE (2013) J Immunol 190: 3732-9 Residues in the heptad repeat a region of the fusion protein modulate the virulence of Sendai virus in mice. Luque LE, Bridges OA, Mason JN, Boyd KL, Portner A, Russell CJ (2010) J Virol 84: 810-21 Mutations of Epstein-Barr virus gH that are differentially able to support fusion with B cells or epithelial cells. Wu L, Borza CM, Hutt-Fletcher LM (2005) J Virol 79: 10923-30 Lung CD8+ T Cell Impairment Occurs during Human Metapneumovirus Infection despite Virus-Like Particle Induction of Functional CD8+ T Cells. Wen SC, Schuster JE, Gilchuk P, Boyd KL, Joyce S, Williams JV (2015) J Virol 89: 8713-26 The transmembrane domain of the respiratory syncytial virus F protein is an orientation-independent apical plasma membrane sorting sequence. Brock SC, Heck JM, McGraw PA, Crowe JE (2005) J Virol 79: 12528-35 The human metapneumovirus fusion protein mediates entry via an interaction with RGD-binding integrins. Cox RG, Livesay SB, Johnson M, Ohi MD, Williams JV (2012) J Virol 86: 12148-60 Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis. Hotard AL, Lee S, Currier MG, Crowe JE, Sakamoto K, Newcomb DC, Peebles RS, Plemper RK, Moore ML (2015) J Virol 89: 512-22 Human metapneumovirus fusion protein vaccines that are immunogenic and protective in cotton rats. Cseke G, Wright DW, Tollefson SJ, Johnson JE, Crowe JE, Williams JV (2007) J Virol 81: 698-707 Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion. Kirschner AN, Lowrey AS, Longnecker R, Jardetzky TS (2007) J Virol 81: 9216-29 A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo. Williams JV, Chen Z, Cseke G, Wright DW, Keefer CJ, Tollefson SJ, Hessell A, Podsiad A, Shepherd BE, Sanna PP, Burton DR, Crowe JE, Williamson RA (2007) J Virol 81: 8315-24 Venezuelan equine encephalitis virus replicon particles encoding respiratory syncytial virus surface glycoproteins induce protective mucosal responses in mice and cotton rats. Mok H, Lee S, Utley TJ, Shepherd BE, Polosukhin VV, Collier ML, Davis NL, Johnston RE, Crowe JE (2007) J Virol 81: 13710-22 Examination of a fusogenic hexameric core from human metapneumovirus and identification of a potent synthetic peptide inhibitor from the heptad repeat 1 region. Miller SA, Tollefson S, Crowe JE, Williams JV, Wright DW (2007) J Virol 81: 141-9 Thermoresponsive Polymer Nanoparticles Co-deliver RSV F Trimers with a TLR-7/8 Adjuvant. Francica JR, Lynn GM, Laga R, Joyce MG, Ruckwardt TJ, Morabito KM, Chen M, Chaudhuri R, Zhang B, Sastry M, Druz A, Ko K, Choe M, Pechar M, Georgiev IS, Kueltzo LA, Seymour LW, Mascola JR, Kwong PD, Graham BS, Seder RA (2016) Bioconjug Chem 27: 2372-2385 Molecular mechanisms driving respiratory syncytial virus assembly. Shaikh FY, Crowe JE (2013) Future Microbiol 8: 123-31 Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus. Boyington JC, Joyce MG, Sastry M, Stewart-Jones GB, Chen M, Kong WP, Ngwuta JO, Thomas PV, Tsybovsky Y, Yang Y, Zhang B, Chen L, Druz A, Georgiev IS, Ko K, Zhou T, Mascola JR, Graham BS, Kwong PD (2016) PLoS One 11: e0159709 A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV. Wen X, Pickens J, Mousa JJ, Leser GP, Lamb RA, Crowe JE, Jardetzky TS (2016) PLoS One 11: e0155917 Identification of a novel human leucocyte antigen-A*01-restricted cytotoxic T-lymphocyte epitope in the respiratory syncytial virus fusion protein. Rock MT, Crowe JE (2003) Immunology 108: 474-80 Respiratory syncytial virus (RSV) fusion protein expressed by recombinant Sendai virus elicits B-cell and T-cell responses in cotton rats and confers protection against RSV subtypes A and B. Zhan X, Hurwitz JL, Krishnamurthy S, Takimoto T, Boyd K, Scroggs RA, Surman S, Portner A, Slobod KS (2007) Vaccine 25: 8782-93 Immunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates. Bates JT, Pickens JA, Schuster JE, Johnson M, Tollefson SJ, Williams JV, Davis NL, Johnston RE, Schultz-Darken N, Slaughter JC, Smith-House F, Crowe JE (2016) Vaccine 34: 950-6 Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein. Crowe JE, Firestone CY, Crim R, Beeler JA, Coelingh KL, Barbas CF, Burton DR, Chanock RM, Murphy BR (1998) Virology 252: 373-5 Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein. Bates JT, Keefer CJ, Slaughter JC, Kulp DW, Schief WR, Crowe JE (2014) Virology 454-455: 139-44 Saturation of TRIM5 alpha-mediated restriction of HIV-1 infection depends on the stability of the incoming viral capsid. Shi J, Aiken C (2006) Virology 350: 493-500 Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years. Yang CF, Wang CK, Tollefson SJ, Piyaratna R, Lintao LD, Chu M, Liem A, Mark M, Spaete RR, Crowe JE, Williams JV (2009) Virol J 6: 138
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.