Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, Wright PF, Crowe JE (2004) N Engl J Med 350: 443-50 Burden of human metapneumovirus infection in young children. Edwards KM, Zhu Y, Griffin MR, Weinberg GA, Hall CB, Szilagyi PG, Staat MA, Iwane M, Prill MM, Williams JV, New Vaccine Surveillance Network (2013) N Engl J Med 368: 633-43 Community-acquired pneumonia requiring hospitalization among U.S. children. Jain S, Williams DJ, Arnold SR, Ampofo K, Bramley AM, Reed C, Stockmann C, Anderson EJ, Grijalva CG, Self WH, Zhu Y, Patel A, Hymas W, Chappell JD, Kaufman RA, Kan JH, Dansie D, Lenny N, Hillyard DR, Haynes LM, Levine M, Lindstrom S, Winchell JM, Katz JM, Erdman D, Schneider E, Hicks LA, Wunderink RG, Edwards KM, Pavia AT, McCullers JA, Finelli L, CDC EPIC Study Team (2015) N Engl J Med 372: 835-45 Viral acute lower respiratory infections impair CD8+ T cells through PD-1. Erickson JJ, Gilchuk P, Hastings AK, Tollefson SJ, Johnson M, Downing MB, Boyd KL, Johnson JE, Kim AS, Joyce S, Williams JV (2012) J Clin Invest 122: 2967-82 Human metapneumovirus infection in children hospitalized for wheezing. Williams JV, Tollefson SJ, Heymann PW, Carper HT, Patrie J, Crowe JE (2005) J Allergy Clin Immunol 115: 1311-2 Integrin alphavbeta1 promotes infection by human metapneumovirus. Cseke G, Maginnis MS, Cox RG, Tollefson SJ, Podsiad AB, Wright DW, Dermody TS, Williams JV (2009) Proc Natl Acad Sci U S A 106: 1566-71 Unveiling the burden of influenza-associated pneumococcal pneumonia. Grijalva CG, Griffin MR (2012) J Infect Dis 205: 355-7 The role of human metapneumovirus in upper respiratory tract infections in children: a 20-year experience. Williams JV, Wang CK, Yang CF, Tollefson SJ, House FS, Heck JM, Chu M, Brown JB, Lintao LD, Quinto JD, Chu D, Spaete RR, Edwards KM, Wright PF, Crowe JE (2006) J Infect Dis 193: 387-95 Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults. Williams JV, Crowe JE, Enriquez R, Minton P, Peebles RS, Hamilton RG, Higgins S, Griffin M, Hartert TV (2005) J Infect Dis 192: 1149-53 A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections. Williams JV, Martino R, Rabella N, Otegui M, Parody R, Heck JM, Crowe JE (2005) J Infect Dis 192: 1061-5 Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults. Widmer K, Zhu Y, Williams JV, Griffin MR, Edwards KM, Talbot HK (2012) J Infect Dis 206: 56-62 Population-based incidence of human metapneumovirus infection among hospitalized children. Williams JV, Edwards KM, Weinberg GA, Griffin MR, Hall CB, Zhu Y, Szilagyi PG, Wang CK, Yang CF, Silva D, Ye D, Spaete RR, Crowe JE (2010) J Infect Dis 201: 1890-8 Acute Viral Respiratory Infection Rapidly Induces a CD8+ T Cell Exhaustion-like Phenotype. Erickson JJ, Lu P, Wen S, Hastings AK, Gilchuk P, Joyce S, Shyr Y, Williams JV (2015) J Immunol 195: 4319-30 Acute clearance of human metapneumovirus occurs independently of natural killer cells. Wen SC, Tollefson SJ, Johnson M, Gilchuk P, Boyd KL, Shepherd B, Joyce S, Williams JV (2014) J Virol 88: 10963-9 A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo. Williams JV, Chen Z, Cseke G, Wright DW, Keefer CJ, Tollefson SJ, Hessell A, Podsiad A, Shepherd BE, Sanna PP, Burton DR, Crowe JE, Williamson RA (2007) J Virol 81: 8315-24 Examination of a fusogenic hexameric core from human metapneumovirus and identification of a potent synthetic peptide inhibitor from the heptad repeat 1 region. Miller SA, Tollefson S, Crowe JE, Williams JV, Wright DW (2007) J Virol 81: 141-9 The cotton rat (Sigmodon hispidus) is a permissive small animal model of human metapneumovirus infection, pathogenesis, and protective immunity. Williams JV, Tollefson SJ, Johnson JE, Crowe JE (2005) J Virol 79: 10944-51 An alphavirus replicon-based human metapneumovirus vaccine is immunogenic and protective in mice and cotton rats. Mok H, Tollefson SJ, Podsiad AB, Shepherd BE, Polosukhin VV, Johnston RE, Williams JV, Crowe JE (2008) J Virol 82: 11410-8 The human metapneumovirus fusion protein mediates entry via an interaction with RGD-binding integrins. Cox RG, Livesay SB, Johnson M, Ohi MD, Williams JV (2012) J Virol 86: 12148-60 Human metapneumovirus fusion protein vaccines that are immunogenic and protective in cotton rats. Cseke G, Wright DW, Tollefson SJ, Johnson JE, Crowe JE, Williams JV (2007) J Virol 81: 698-707 Role of type I interferon signaling in human metapneumovirus pathogenesis and control of viral replication. Hastings AK, Erickson JJ, Schuster JE, Boyd KL, Tollefson SJ, Johnson M, Gilchuk P, Joyce S, Williams JV (2015) J Virol 89: 4405-20 Lung CD8+ T Cell Impairment Occurs during Human Metapneumovirus Infection despite Virus-Like Particle Induction of Functional CD8+ T Cells. Wen SC, Schuster JE, Gilchuk P, Boyd KL, Joyce S, Williams JV (2015) J Virol 89: 8713-26 Incidence and Risk Factors for Respiratory Syncytial Virus and Human Metapneumovirus Infections among Children in the Remote Highlands of Peru. Wu A, Budge PJ, Williams J, Griffin MR, Edwards KM, Johnson M, Zhu Y, Hartinger S, Verastegui H, Gil AI, Lanata CF, Grijalva CG (2015) PLoS One 10: e0130233 A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV. Wen X, Pickens J, Mousa JJ, Leser GP, Lamb RA, Crowe JE, Jardetzky TS (2016) PLoS One 11: e0155917 Human metapneumovirus as a major cause of human respiratory tract disease. Crowe JE (2004) Pediatr Infect Dis J 23: S215-21 Novel HLA-A2-restricted human metapneumovirus epitopes reduce viral titers in mice and are recognized by human T cells. Hastings AK, Gilchuk P, Joyce S, Williams JV (2016) Vaccine 34: 2663-70 Immunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates. Bates JT, Pickens JA, Schuster JE, Johnson M, Tollefson SJ, Williams JV, Davis NL, Johnston RE, Schultz-Darken N, Slaughter JC, Smith-House F, Crowe JE (2016) Vaccine 34: 950-6 Real-time reverse transcriptase PCR assay for improved detection of human metapneumovirus. Klemenc J, Asad Ali S, Johnson M, Tollefson SJ, Talbot HK, Hartert TV, Edwards KM, Williams JV (2012) J Clin Virol 54: 371-5 Human metapneumovirus nucleoprotein and phosphoprotein interact and provide the minimal requirements for inclusion body formation. Derdowski A, Peters TR, Glover N, Qian R, Utley TJ, Burnett A, Williams JV, Spearman P, Crowe JE (2008) J Gen Virol 89: 2698-2708 Immunology of viral respiratory tract infection in infancy. Crowe JE, Williams JV (2003) Paediatr Respir Rev 4: 112-9 Identification of potential human respiratory syncytial virus and metapneumovirus T cell epitopes using computational prediction and MHC binding assays. Rock MT, McKinney BA, Yoder SM, Prudom CE, Wright DW, Crowe JE (2011) J Immunol Methods 374: 13-7 Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years. Yang CF, Wang CK, Tollefson SJ, Piyaratna R, Lintao LD, Chu M, Liem A, Mark M, Spaete RR, Crowe JE, Williams JV (2009) Virol J 6: 138
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