Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW (2000) Nature 408: 1004-8 Structural biology. Controlling the caspases. Fesik SW, Shi Y (2001) Science 294: 1477-8 Calpains play a role in insulin secretion and action. Sreenan SK, Zhou YP, Otani K, Hansen PA, Currie KP, Pan CY, Lee JP, Ostrega DM, Pugh W, Horikawa Y, Cox NJ, Hanis CL, Burant CF, Fox AP, Bell GI, Polonsky KS (2001) Diabetes 50: 2013-20 Regulation of focal complex composition and disassembly by the calcium-dependent protease calpain. Bhatt A, Kaverina I, Otey C, Huttenlocher A (2002) J Cell Sci 115: 3415-25 Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function. Davies SS, Amarnath V, Montine KS, Bernoud-Hubac N, Boutaud O, Montine TJ, Roberts LJ (2002) FASEB J 16: 715-7 c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells. Gregory MA, Hann SR (2000) Mol Cell Biol 20: 2423-35 Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction. Henrich LM, Smith JA, Kitt D, Errington TM, Nguyen B, Traish AM, Lannigan DA (2003) Mol Cell Biol 23: 5979-88 Nuclear survivin as a biomarker for non-small-cell lung cancer. Lu B, Gonzalez A, Massion PP, Shyr Y, Shaktour B, Carbone DP, Hallahan DE (2004) Br J Cancer 91: 537-40 Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB. Connolly JL, Rodgers SE, Clarke P, Ballard DW, Kerr LD, Tyler KL, Dermody TS (2000) J Virol 74: 2981-9 Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein sigma3. Ebert DH, Wetzel JD, Brumbaugh DE, Chance SR, Stobie LE, Baer GS, Dermody TS (2001) J Virol 75: 3197-206 Reovirus-induced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors. Debiasi RL, Squier MK, Pike B, Wynes M, Dermody TS, Cohen JJ, Tyler KL (1999) J Virol 73: 695-701 Reovirus variants selected for resistance to ammonium chloride have mutations in viral outer-capsid protein sigma3. Clark KM, Wetzel JD, Gu Y, Ebert DH, McAbee SA, Stoneman EK, Baer GS, Zhu Y, Wilson GJ, Prasad BV, Dermody TS (2006) J Virol 80: 671-81 Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64. Baer GS, Dermody TS (1997) J Virol 71: 4921-8 IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. Ji C, Kozak KR, Marnett LJ (2001) J Biol Chem 276: 18223-8 Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. Ebert DH, Deussing J, Peters C, Dermody TS (2002) J Biol Chem 277: 24609-17 Role of cathepsins in blastocyst hatching in the golden hamster. Sireesha GV, Mason RW, Hassanein M, Tonack S, Navarrete Santos A, Fischer B, Seshagiri PB (2008) Mol Hum Reprod 14: 337-46 Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype. Montine KS, Reich E, Neely MD, Sidell KR, Olson SJ, Markesbery WR, Montine TJ (1998) J Neuropathol Exp Neurol 57: 415-25 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites. Picklo MJ, Amarnath V, McIntyre JO, Graham DG, Montine TJ (1999) J Neurochem 72: 1617-24 Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis. Gama V, Yoshida T, Gomez JA, Basile DP, Mayo LD, Haas AL, Matsuyama S (2006) Exp Cell Res 312: 488-99 Pressure-induced regulation of IL-6 in retinal glial cells: involvement of the ubiquitin/proteasome pathway and NFkappaB. Sappington RM, Calkins DJ (2006) Invest Ophthalmol Vis Sci 47: 3860-9 Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d. Kim JC, Spence RA, Currier PF, Lu X, Denison MR (1995) Virology 208: 1-8 A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin. Zhou YP, Sreenan S, Pan CY, Currie KP, Bindokas VP, Horikawa Y, Lee JP, Ostrega D, Ahmed N, Baldwin AC, Cox NJ, Fox AP, Miller RJ, Bell GI, Polonsky KS (2003) Metabolism 52: 528-34 Systemic administration of a proteasome inhibitor does not cause nigrostriatal dopamine degeneration. Mathur BN, Neely MD, Dyllick-Brenzinger M, Tandon A, Deutch AY (2007) Brain Res 1168: 83-9 Hypoxia alters cathepsin B / inhibitor profiles in oral carcinoma cell lines. Wickramasinghe NS, Banerjee K, Nagaraj NS, Vigneswaran N, Zacharias W (2005) Anticancer Res 25: 2841-9 Expression of cysteine proteinase of Clonorchis sinensis and its use in serodiagnosis of clonorchiasis. Na BK, Lee HJ, Cho SH, Lee HW, Cho JH, Kho WG, Lee JS, Lee JS, Song KJ, Park PH, Song CY, Kim TS (2002) J Parasitol 88: 1000-6
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.