Pif1 family helicases suppress genome instability at G-quadruplex motifs. Paeschke K, Bochman ML, Garcia PD, Cejka P, Friedman KL, Kowalczykowski SC, Zakian VA (2013) Nature 497: 458-62 DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase. Paeschke K, Capra JA, Zakian VA (2011) Cell 145: 678-91 Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH, TCGA Research Network, Noushmehr H, Iavarone A, Verhaak RG (2016) Cell 164: 550-63 The power of pumping together; deconstructing the engine of a DNA replication machine. Eichman BF, Fanning E (2004) Cell 119: 3-4 Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Smider V, Rathmell WK, Lieber MR, Chu G (1994) Science 266: 288-91 The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability. Dungrawala H, Rose KL, Bhat KP, Mohni KN, Glick GG, Couch FB, Cortez D (2015) Mol Cell 59: 998-1010 Checkpoint signaling from a single DNA interstrand crosslink. Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J (2009) Mol Cell 35: 704-15 T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent. Zhang F, Boothby M (2006) J Exp Med 203: 1493-505 ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Couch FB, Bansbach CE, Driscoll R, Luzwick JW, Glick GG, Bétous R, Carroll CM, Jung SY, Qin J, Cimprich KA, Cortez D (2013) Genes Dev 27: 1610-23 The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Bansbach CE, Bétous R, Lovejoy CA, Glick GG, Cortez D (2009) Genes Dev 23: 2405-14 SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication. Bétous R, Mason AC, Rambo RP, Bansbach CE, Badu-Nkansah A, Sirbu BM, Eichman BF, Cortez D (2012) Genes Dev 26: 151-62 BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J (2000) Genes Dev 14: 927-39 Lsh, a member of the SNF2 family, is required for genome-wide methylation. Dennis K, Fan T, Geiman T, Yan Q, Muegge K (2001) Genes Dev 15: 2940-4 Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling. Cortez D (2005) Genes Dev 19: 1007-12 Rare variants in RTEL1 are associated with familial interstitial pneumonia. Cogan JD, Kropski JA, Zhao M, Mitchell DB, Rives L, Markin C, Garnett ET, Montgomery KH, Mason WR, McKean DF, Powers J, Murphy E, Olson LM, Choi L, Cheng DS, Blue EM, Young LR, Lancaster LH, Steele MP, Brown KK, Schwarz MI, Fingerlin TE, Schwartz DA, Lawson WE, Loyd JE, Zhao Z, Phillips JA, Blackwell TS (2015) Am J Respir Crit Care Med 191: 646-55 High-affinity DNA binding by a Mot1p-TBP complex: implications for TAF-independent transcription. Gumbs OH, Campbell AM, Weil PA (2003) EMBO J 22: 3131-41 Mot1p is essential for TBP recruitment to selected promoters during in vivo gene activation. Andrau JC, Van Oevelen CJ, Van Teeffelen HA, Weil PA, Holstege FC, Timmers HT (2002) EMBO J 21: 5173-83 SMARCAL1 maintains telomere integrity during DNA replication. Poole LA, Zhao R, Glick GG, Lovejoy CA, Eischen CM, Cortez D (2015) Proc Natl Acad Sci U S A 112: 14864-9 A structure-specific nucleic acid-binding domain conserved among DNA repair proteins. Mason AC, Rambo RP, Greer B, Pritchett M, Tainer JA, Cortez D, Eichman BF (2014) Proc Natl Acad Sci U S A 111: 7618-23 Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc. Tworkowski KA, Chakraborty AA, Samuelson AV, Seger YR, Narita M, Hannon GJ, Lowe SW, Tansey WP (2008) Proc Natl Acad Sci U S A 105: 6103-8 Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks. Rathmell WK, Chu G (1994) Proc Natl Acad Sci U S A 91: 7623-7 Oncogenic protein MTBP interacts with MYC to promote tumorigenesis. Grieb BC, Gramling MW, Arrate MP, Chen X, Beauparlant SL, Haines DS, Xiao H, Eischen CM (2014) Cancer Res 74: 3591-602 Phosphorylation of a C-terminal auto-inhibitory domain increases SMARCAL1 activity. Carroll C, Bansbach CE, Zhao R, Jung SY, Qin J, Cortez D (2014) Nucleic Acids Res 42: 918-25 Mms1 binds to G-rich regions in Saccharomyces cerevisiae and influences replication and genome stability. Wanzek K, Schwindt E, Capra JA, Paeschke K (2017) Nucleic Acids Res 45: 7796-7806 A proteomics analysis of yeast Mot1p protein-protein associations: insights into mechanism. Arnett DR, Jennings JL, Tabb DL, Link AJ, Weil PA (2008) Mol Cell Proteomics 7: 2090-106 NF-κB forms a complex with the chromatin remodeler BRG1 to regulate Schwann cell differentiation. Limpert AS, Bai S, Narayan M, Wu J, Yoon SO, Carter BD, Lu QR (2013) J Neurosci 33: 2388-97 The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage. Sabouri N, Capra JA, Zakian VA (2014) BMC Biol 12: 101 NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter. Huth JR, Yu L, Collins I, Mack J, Mendoza R, Isaac B, Braddock DT, Muchmore SW, Comess KM, Fesik SW, Clore GM, Levens D, Hajduk PJ (2004) J Med Chem 47: 4851-7 MOT1 can activate basal transcription in vitro by regulating the distribution of TATA binding protein between promoter and nonpromoter sites. Muldrow TA, Campbell AM, Weil PA, Auble DT (1999) Mol Cell Biol 19: 2835-45 The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex. Pebernard S, Wohlschlegel J, McDonald WH, Yates JR, Boddy MN (2006) Mol Cell Biol 26: 1617-30 Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants. Errami A, Smider V, Rathmell WK, He DM, Hendrickson EA, Zdzienicka MZ, Chu G (1996) Mol Cell Biol 16: 1519-26 Yeast Est2p affects telomere length by influencing association of Rap1p with telomeric chromatin. Ji H, Adkins CJ, Cartwright BR, Friedman KL (2008) Mol Cell Biol 28: 2380-90 Swi1 and Swi3 are components of a replication fork protection complex in fission yeast. Noguchi E, Noguchi C, McDonald WH, Yates JR, Russell P (2004) Mol Cell Biol 24: 8342-55 Structure and functional implications of a complex containing a segment of U6 RNA bound by a domain of Prp24. Martin-Tumasz S, Reiter NJ, Brow DA, Butcher SE (2010) RNA 16: 792-804 Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes. Sims AC, Ostermann J, Denison MR (2000) J Virol 74: 5647-54 Respiratory syncytial virus induces host RNA stress granules to facilitate viral replication. Lindquist ME, Lifland AW, Utley TJ, Santangelo PJ, Crowe JE (2010) J Virol 84: 12274-84 Recruitment of the SWI/SNF protein Brg1 by a multiprotein complex effects transcriptional repression in murine erythroid progenitors. Xu Z, Meng X, Cai Y, Koury MJ, Brandt SJ (2006) Biochem J 399: 297-304 ATR signalling: more than meeting at the fork. Nam EA, Cortez D (2011) Biochem J 436: 527-36 Yeast Taf170 is encoded by MOT1 and exists in a TATA box-binding protein (TBP)-TBP-associated factor complex distinct from transcription factor IID. Poon D, Campbell AM, Bai Y, Weil PA (1994) J Biol Chem 269: 23135-40 Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress. Guler GD, Liu H, Vaithiyalingam S, Arnett DR, Kremmer E, Chazin WJ, Fanning E (2012) J Biol Chem 287: 6469-81
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.