Systems analysis of protein modification and cellular responses induced by electrophile stress. Jacobs AT, Marnett LJ (2010) Acc Chem Res 43: 673-83 Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources. Stone MP, Cho YJ, Huang H, Kim HY, Kozekov ID, Kozekova A, Wang H, Minko IG, Lloyd RS, Harris TM, Rizzo CJ (2008) Acc Chem Res 41: 793-804 17 alpha-hydroxylase/17,20-lyase deficiency: from clinical investigation to molecular definition. Yanase T, Simpson ER, Waterman MR (1991) Endocr Rev 12: 91-108 DC isoketal-modified proteins activate T cells and promote hypertension. Kirabo A, Fontana V, de Faria AP, Loperena R, Galindo CL, Wu J, Bikineyeva AT, Dikalov S, Xiao L, Chen W, Saleh MA, Trott DW, Itani HA, Vinh A, Amarnath V, Amarnath K, Guzik TJ, Bernstein KE, Shen XZ, Shyr Y, Chen SC, Mernaugh RL, Laffer CL, Elijovich F, Davies SS, Moreno H, Madhur MS, Roberts J, Harrison DG (2014) J Clin Invest 124: 4642-56 Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels. Fukuda K, Davies SS, Nakajima T, Ong BH, Kupershmidt S, Fessel J, Amarnath V, Anderson ME, Boyden PA, Viswanathan PC, Roberts LJ, Balser JR (2005) Circ Res 97: 1262-9 Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigenetics. Galligan JJ, Rose KL, Beavers WN, Hill S, Tallman KA, Tansey WP, Marnett LJ (2014) J Am Chem Soc 136: 11864-6 Formation of a N2-dG:N2-dG carbinolamine DNA cross-link by the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N2-dG adduct. Huang H, Wang H, Kozekova A, Rizzo CJ, Stone MP (2011) J Am Chem Soc 133: 16101-10 Mechanism of the third oxidative step in the conversion of androgens to estrogens by cytochrome P450 19A1 steroid aromatase. Yoshimoto FK, Guengerich FP (2014) J Am Chem Soc 136: 15016-25 DNA interchain cross-links formed by acrolein and crotonaldehyde. Kozekov ID, Nechev LV, Moseley MS, Harris CM, Rizzo CJ, Stone MP, Harris TM (2003) J Am Chem Soc 125: 50-61 Rearrangement of the (6S,8R,11S) and (6R,8S,11R) exocyclic 1,N2-deoxyguanosine adducts of trans-4-hydroxynonenal to N2-deoxyguanosine cyclic hemiacetal adducts when placed complementary to cytosine in duplex DNA. Huang H, Wang H, Qi N, Kozekova A, Rizzo CJ, Stone MP (2008) J Am Chem Soc 130: 10898-906 Site-specific synthesis and reactivity of oligonucleotides containing stereochemically defined 1,N2-deoxyguanosine adducts of the lipid peroxidation product trans-4-hydroxynonenal. Wang H, Kozekov ID, Harris TM, Rizzo CJ (2003) J Am Chem Soc 125: 5687-700 JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer. Song W, Ma Y, Wang J, Brantley-Sieders D, Chen J (2014) Cancer Res 74: 2444-54 Retinoic acid biosynthesis by normal human breast epithelium is via aldehyde dehydrogenase 6, absent in MCF-7 cells. Rexer BN, Zheng WL, Ong DE (2001) Cancer Res 61: 7065-70 The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts. Dexheimer TS, Kozekova A, Rizzo CJ, Stone MP, Pommier Y (2008) Nucleic Acids Res 36: 4128-36 Mechanism of perturbation of integrin-mediated cell-matrix interactions by reactive carbonyl compounds and its implication for pathogenesis of diabetic nephropathy. Pedchenko VK, Chetyrkin SV, Chuang P, Ham AJ, Saleem MA, Mathieson PW, Hudson BG, Voziyan PA (2005) Diabetes 54: 2952-60 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Wen W, Zheng W, Okada Y, Takeuchi F, Tabara Y, Hwang JY, Dorajoo R, Li H, Tsai FJ, Yang X, He J, Wu Y, He M, Zhang Y, Liang J, Guo X, Sheu WH, Delahanty R, Guo X, Kubo M, Yamamoto K, Ohkubo T, Go MJ, Liu JJ, Gan W, Chen CC, Gao Y, Li S, Lee NR, Wu C, Zhou X, Song H, Yao J, Lee IT, Long J, Tsunoda T, Akiyama K, Takashima N, Cho YS, Ong RT, Lu L, Chen CH, Tan A, Rice TK, Adair LS, Gui L, Allison M, Lee WJ, Cai Q, Isomura M, Umemura S, Kim YJ, Seielstad M, Hixson J, Xiang YB, Isono M, Kim BJ, Sim X, Lu W, Nabika T, Lee J, Lim WY, Gao YT, Takayanagi R, Kang DH, Wong TY, Hsiung CA, Wu IC, Juang JM, Shi J, Choi BY, Aung T, Hu F, Kim MK, Lim WY, Wang TD, Shin MH, Lee J, Ji BT, Lee YH, Young TL, Shin DH, Chun BY, Cho MC, Han BG, Hwu CM, Assimes TL, Absher D, Yan X, Kim E, Kuo JZ, Kwon S, Taylor KD, Chen YD, Rotter JI, Qi L, Zhu D, Wu T, Mohlke KL, Gu D, Mo Z, Wu JY, Lin X, Miki T, Tai ES, Lee JY, Kato N, Shu XO, Tanaka T (2014) Hum Mol Genet 23: 5492-504 Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis. Liang A, Wang Y, Woodard LE, Wilson MH, Sharma R, Awasthi YC, Du J, Mitch WE, Cheng J (2012) J Pathol 228: 448-58 Alkylation damage by lipid electrophiles targets functional protein systems. Codreanu SG, Ullery JC, Zhu J, Tallman KA, Beavers WN, Porter NA, Marnett LJ, Zhang B, Liebler DC (2014) Mol Cell Proteomics 13: 849-59 An azido-biotin reagent for use in the isolation of protein adducts of lipid-derived electrophiles by streptavidin catch and photorelease. Kim HY, Tallman KA, Liebler DC, Porter NA (2009) Mol Cell Proteomics 8: 2080-9 Assembly Dynamics and Stoichiometry of the Apoptosis Signal-regulating Kinase (ASK) Signalosome in Response to Electrophile Stress. Federspiel JD, Codreanu SG, Palubinsky AM, Winland AJ, Betanzos CM, McLaughlin B, Liebler DC (2016) Mol Cell Proteomics 15: 1947-61 Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal. Codreanu SG, Zhang B, Sobecki SM, Billheimer DD, Liebler DC (2009) Mol Cell Proteomics 8: 670-80 Isolevuglandin-type lipid aldehydes induce the inflammatory response of macrophages by modifying phosphatidylethanolamines and activating the receptor for advanced glycation endproducts. Guo L, Chen Z, Amarnath V, Yancey PG, Van Lenten BJ, Savage JR, Fazio S, Linton MF, Davies SS (2015) Antioxid Redox Signal 22: 1633-45 Isotopically nonstationary C flux analysis of cyanobacterial isobutyraldehyde production. Jazmin LJ, Xu Y, Cheah YE, Adebiyi AO, Johnson CH, Young JD (2017) Metab Eng 42: 9-18 ALDH1A1 mRNA expression in association with prognosis of triple-negative breast cancer. Liu Y, Baglia M, Zheng Y, Blot W, Bao PP, Cai H, Nechuta S, Zheng W, Cai Q, Shu XO (2015) Oncotarget 6: 41360-9 Compound heterozygous mutations (Arg 239----stop, Pro 342----Thr) in the CYP17 (P45017 alpha) gene lead to ambiguous external genitalia in a male patient with partial combined 17 alpha-hydroxylase/17,20-lyase deficiency. Ahlgren R, Yanase T, Simpson ER, Winter JS, Waterman MR (1992) J Clin Endocrinol Metab 74: 667-72 Combined 17 alpha-hydroxylase/17,20-lyase deficiency due to a 7-basepair duplication in the N-terminal region of the cytochrome P45017 alpha (CYP17) gene. Yanase T, Sanders D, Shibata A, Matsui N, Simpson ER, Waterman MR (1990) J Clin Endocrinol Metab 70: 1325-9 Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function. Davies SS, Amarnath V, Montine KS, Bernoud-Hubac N, Boutaud O, Montine TJ, Roberts LJ (2002) FASEB J 16: 715-7 Quantitative chemoproteomics for site-specific analysis of protein alkylation by 4-hydroxy-2-nonenal in cells. Yang J, Tallman KA, Porter NA, Liebler DC (2015) Anal Chem 87: 2535-41 HemX Modulates Glutamyl-tRNA Reductase Abundance To Regulate Heme Biosynthesis. Choby JE, Grunenwald CM, Celis AI, Gerdes SY, DuBois JL, Skaar EP (2018) MBio 9: Covalent binding of isoketals to ethanolamine phospholipids. Bernoud-Hubac N, Fay LB, Armarnath V, Guichardant M, Bacot S, Davies SS, Roberts LJ, Lagarde M (2004) Free Radic Biol Med 37: 1604-11 Localization of isoketal adducts in vivo using a single-chain antibody. Davies SS, Talati M, Wang X, Mernaugh RL, Amarnath V, Fessel J, Meyrick BO, Sheller J, Roberts LJ (2004) Free Radic Biol Med 36: 1163-74 Reactive gamma-ketoaldehydes as novel activators of hepatic stellate cells in vitro. Longato L, Andreola F, Davies SS, Roberts JL, Fusai G, Pinzani M, Moore K, Rombouts K (2017) Free Radic Biol Med 102: 162-173 Enhanced gamma-glutamyl transpeptidase expression and selective loss of CuZn superoxide dismutase in hepatic iron overload. Brown KE, Kinter MT, Oberley TD, Freeman ML, Frierson HF, Ridnour LA, Tao Y, Oberley LW, Spitz DR (1998) Free Radic Biol Med 24: 545-55 Identification of novel bioactive aldehyde-modified phosphatidylethanolamines formed by lipid peroxidation. Guo L, Chen Z, Amarnath V, Davies SS (2012) Free Radic Biol Med 53: 1226-38 Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition. Liu W, Porter NA, Schneider C, Brash AR, Yin H (2011) Free Radic Biol Med 50: 166-78 Congeners of N(alpha)-acetyl-L-cysteine but not aminoguanidine act as neuroprotectants from the lipid peroxidation product 4-hydroxy-2-nonenal. Neely MD, Zimmerman L, Picklo MJ, Ou JJ, Morales CR, Montine KS, Amaranth V, Montine TJ (2000) Free Radic Biol Med 29: 1028-36 Reactive gamma-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis. Stavrovskaya IG, Baranov SV, Guo X, Davies SS, Roberts LJ, Kristal BS (2010) Free Radic Biol Med 49: 567-79
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