DNA topoisomerase II in therapy-related acute promyelocytic leukemia. Mistry AR, Felix CA, Whitmarsh RJ, Mason A, Reiter A, Cassinat B, Parry A, Walz C, Wiemels JL, Segal MR, Adès L, Blair IA, Osheroff N, Peniket AJ, Lafage-Pochitaloff M, Cross NC, Chomienne C, Solomon E, Fenaux P, Grimwade D (2005) N Engl J Med 352: 1529-38 The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions. Mullins EA, Shi R, Parsons ZD, Yuen PK, David SS, Igarashi Y, Eichman BF (2015) Nature 527: 254-8 An unprecedented nucleic acid capture mechanism for excision of DNA damage. Rubinson EH, Gowda AS, Spratt TE, Gold B, Eichman BF (2010) Nature 468: 406-11 Pif1 family helicases suppress genome instability at G-quadruplex motifs. Paeschke K, Bochman ML, Garcia PD, Cejka P, Friedman KL, Kowalczykowski SC, Zakian VA (2013) Nature 497: 458-62 ATR: an essential regulator of genome integrity. Cimprich KA, Cortez D (2008) Nat Rev Mol Cell Biol 9: 616-27 What causes mitochondrial DNA deletions in human cells? Krishnan KJ, Reeve AK, Samuels DC, Chinnery PF, Blackwood JK, Taylor RW, Wanrooij S, Spelbrink JN, Lightowlers RN, Turnbull DM (2008) Nat Genet 40: 275-9 Mus81-Eme1 are essential components of a Holliday junction resolvase. Boddy MN, Gaillard PH, McDonald WH, Shanahan P, Yates JR, Russell P (2001) Cell 107: 537-48 Bid plays a role in the DNA damage response. Zinkel SS, Hurov KE, Gross A (2007) Cell 130: 9-10; author reply 10-1 A role for proapoptotic BID in the DNA-damage response. Zinkel SS, Hurov KE, Ong C, Abtahi FM, Gross A, Korsmeyer SJ (2005) Cell 122: 579-91 ATR and ATRIP: partners in checkpoint signaling. Cortez D, Guntuku S, Qin J, Elledge SJ (2001) Science 294: 1713-6 Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver. Chaudhary AK, Nokubo M, Reddy GR, Yeola SN, Morrow JD, Blair IA, Marnett LJ (1994) Science 265: 1580-2 Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Cortez D, Wang Y, Qin J, Elledge SJ (1999) Science 286: 1162-6 Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria. Dejea CM, Fathi P, Craig JM, Boleij A, Taddese R, Geis AL, Wu X, DeStefano Shields CE, Hechenbleikner EM, Huso DL, Anders RA, Giardiello FM, Wick EC, Wang H, Wu S, Pardoll DM, Housseau F, Sears CL (2018) Science 359: 592-597 Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, Lozano G, Pikarsky E, Forshew T, Rosenfeld N, Rozenfeld N, Harpaz N, Itzkowitz S, Harris CC, Rotter V, Gorgoulis VG, Oren M (2013) Cancer Cell 23: 634-46 Hdac3 is essential for the maintenance of chromatin structure and genome stability. Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW (2010) Cancer Cell 18: 436-47 Looking for Waldo: a potential thermodynamic signature to DNA damage. Gold B, Stone MP, Marky LA (2014) Acc Chem Res 47: 1446-54 ETAA1 acts at stalled replication forks to maintain genome integrity. Bass TE, Luzwick JW, Kavanaugh G, Carroll C, Dungrawala H, Glick GG, Feldkamp MD, Putney R, Chazin WJ, Cortez D (2016) Nat Cell Biol 18: 1185-1195 Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Bhaskara S, Chyla BJ, Amann JM, Knutson SK, Cortez D, Sun ZW, Hiebert SW (2008) Mol Cell 30: 61-72 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Méndez J, Zou-Yang XH, Kim SY, Hidaka M, Tansey WP, Stillman B (2002) Mol Cell 9: 481-91 Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis. Dumitru R, Gama V, Fagan BM, Bower JJ, Swahari V, Pevny LH, Deshmukh M (2012) Mol Cell 46: 573-83 Checkpoint signaling from a single DNA interstrand crosslink. Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J (2009) Mol Cell 35: 704-15 Life after MOMP. Gama V, Deshmukh M (2015) Mol Cell 58: 199-201 The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability. Dungrawala H, Rose KL, Bhat KP, Mohni KN, Glick GG, Couch FB, Cortez D (2015) Mol Cell 59: 998-1010 Congenital abnormalities: a legacy of cancer treatment? Signorello LB, Friedman DL, Boice JD (2011) J Natl Cancer Inst 103: 358-9 Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response. Desimone MC, Rathmell WK, Threadgill DW (2013) J Natl Cancer Inst 105: 1355-64 Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening. Grohar PJ, Woldemichael GM, Griffin LB, Mendoza A, Chen QR, Yeung C, Currier DG, Davis S, Khanna C, Khan J, McMahon JB, Helman LJ (2011) J Natl Cancer Inst 103: 962-78 Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells. Abbott DW, Freeman ML, Holt JT (1998) J Natl Cancer Inst 90: 978-85 Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase. Chowdhury G, Cho SH, Pegg AE, Guengerich FP (2013) Angew Chem Int Ed Engl 52: 12879-82 DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors. Zaika AI, Slade N, Erster SH, Sansome C, Joseph TW, Pearl M, Chalas E, Moll UM (2002) J Exp Med 196: 765-80 Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA, Correa P, Gobert AP, Polk DB, Peek RM, Wilson KT (2011) Gastroenterology 141: 1696-708.e1-2 Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM, Wilson KT (2014) Gastroenterology 146: 1739-51.e14 Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein. Marnett LJ, Riggins JN, West JD (2003) J Clin Invest 111: 583-93 Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS (2015) J Clin Invest 125: 2646-60 Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham RT (2000) Genes Dev 14: 2989-3002 TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Mordes DA, Glick GG, Zhao R, Cortez D (2008) Genes Dev 22: 1478-89 ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Couch FB, Bansbach CE, Driscoll R, Luzwick JW, Glick GG, Bétous R, Carroll CM, Jung SY, Qin J, Cimprich KA, Cortez D (2013) Genes Dev 27: 1610-23 Analysis of protein dynamics at active, stalled, and collapsed replication forks. Sirbu BM, Couch FB, Feigerle JT, Bhaskara S, Hiebert SW, Cortez D (2011) Genes Dev 25: 1320-7 Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling. Cortez D (2005) Genes Dev 19: 1007-12 Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ (2000) Genes Dev 14: 1448-59 Timing is everything: regulation of mitotic exit and cytokinesis by the MEN and SIN. McCollum D, Gould KL (2001) Trends Cell Biol 11: 89-95
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