Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Verma R, Aravind L, Oania R, McDonald WH, Yates JR, Koonin EV, Deshaies RJ (2002) Science 298: 611-5 Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells. Zuber MX, Simpson ER, Waterman MR (1986) Science 234: 1258-61 Regulation of transcriptional activation domain function by ubiquitin. Salghetti SE, Caudy AA, Chenoweth JG, Tansey WP (2001) Science 293: 1651-3 Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain. Flick K, Ouni I, Wohlschlegel JA, Capati C, McDonald WH, Yates JR, Kaiser P (2004) Nat Cell Biol 6: 634-41 Transcriptional regulation: RUPture in the ER. Tansey WP (2000) Nat Cell Biol 2: E175-7 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Méndez J, Zou-Yang XH, Kim SY, Hidaka M, Tansey WP, Stillman B (2002) Mol Cell 9: 481-91 Proteasomal ATPases link ubiquitylation of histone H2B to methylation of histone H3. Ezhkova E, Tansey WP (2004) Mol Cell 13: 435-42 Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. Arad M, Moskowitz IP, Patel VV, Ahmad F, Perez-Atayde AR, Sawyer DB, Walter M, Li GH, Burgon PG, Maguire CT, Stapleton D, Schmitt JP, Guo XX, Pizard A, Kupershmidt S, Roden DM, Berul CI, Seidman CE, Seidman JG (2003) Circulation 107: 2850-6 Structures of the multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system. Friemann R, Lee K, Brown EN, Gibson DT, Eklund H, Ramaswamy S (2009) Acta Crystallogr D Biol Crystallogr 65: 24-33 Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits. Griffin TA, Nandi D, Cruz M, Fehling HJ, Kaer LV, Monaco JJ, Colbert RA (1998) J Exp Med 187: 97-104 Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. Dai Z, Quackenbush RC, Courtney KD, Grove M, Cortez D, Reuther GW, Pendergast AM (1998) Genes Dev 12: 1415-24 Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice. Lenferink AE, Simpson JF, Shawver LK, Coffey RJ, Forbes JT, Arteaga CL (2000) Proc Natl Acad Sci U S A 97: 9609-14 Characterization of the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cells. Fonteneau JF, Kavanagh DG, Lirvall M, Sanders C, Cover TL, Bhardwaj N, Larsson M (2003) Blood 102: 4448-55 The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development. Venkateswaran A, Sekhar KR, Levic DS, Melville DB, Clark TA, Rybski WM, Walsh AJ, Skala MC, Crooks PA, Knapik EW, Freeman ML (2014) Cancer Res 74: 38-43 BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition. Hutchinson KE, Lipson D, Stephens PJ, Otto G, Lehmann BD, Lyle PL, Vnencak-Jones CL, Ross JS, Pietenpol JA, Sosman JA, Puzanov I, Miller VA, Pao W (2013) Clin Cancer Res 19: 6696-702 Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2. Sekhar KR, Yan XX, Freeman ML (2002) Oncogene 21: 6829-34 B-Myc is preferentially expressed in hormonally-controlled tissues and inhibits cellular proliferation. Gregory MA, Xiao Q, Cornwall GA, Lutterbach B, Hann SR (2000) Oncogene 19: 4886-95 Multiple cell-type-specific elements regulate Myc protein stability. Herbst A, Salghetti SE, Kim SY, Tansey WP (2004) Oncogene 23: 3863-71 Protein phosphatases and calcium/calmodulin-dependent protein kinase II-dependent synaptic plasticity. Colbran RJ (2004) J Neurosci 24: 8404-9 Hypothalamic peptidyl-glycine alpha-amidating monooxygenase: preliminary characterization. Emeson RB (1984) J Neurosci 4: 2604-13 Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function. Davies SS, Amarnath V, Montine KS, Bernoud-Hubac N, Boutaud O, Montine TJ, Roberts LJ (2002) FASEB J 16: 715-7 Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during down-regulation of the p53 response after multiple types of DNA damage. Joseph TW, Zaika A, Moll UM (2003) FASEB J 17: 1622-30 Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway. Chen M, Tabaczewski P, Truscott SM, Van Kaer L, Stroynowski I (2005) J Immunol 175: 1047-55 Cluster analysis of mass spectrometry data reveals a novel component of SAGA. Powell DW, Weaver CM, Jennings JL, McAfee KJ, He Y, Weil PA, Link AJ (2004) Mol Cell Biol 24: 7249-59 c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells. Gregory MA, Hann SR (2000) Mol Cell Biol 20: 2423-35 Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid. Altman MK, Gopal V, Jia W, Yu S, Hall H, Mills GB, McGinnis AC, Bartlett MG, Jiang G, Madan D, Prestwich GD, Xu Y, Davies MA, Murph MM (2010) Mol Cancer 9: 140 Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB. Connolly JL, Rodgers SE, Clarke P, Ballard DW, Kerr LD, Tyler KL, Dermody TS (2000) J Virol 74: 2981-9 Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells. Tang T, Arbiser JL, Brandt SJ (2002) J Biol Chem 277: 18365-72 How does arrestin assemble MAPKs into a signaling complex? Song X, Coffa S, Fu H, Gurevich VV (2009) J Biol Chem 284: 685-95 Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. Anderson KA, Noeldner PK, Reece K, Wadzinski BE, Means AR (2004) J Biol Chem 279: 31708-16 Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation. Zaika A, Marchenko N, Moll UM (1999) J Biol Chem 274: 27474-80 Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)·extracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1. Mazalouskas MD, Godoy-Ruiz R, Weber DJ, Zimmer DB, Honkanen RE, Wadzinski BE (2014) J Biol Chem 289: 4219-32 LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle. Thomson DM, Brown JD, Fillmore N, Condon BM, Kim HJ, Barrow JR, Winder WW (2007) Am J Physiol Endocrinol Metab 293: E1572-9 AMPK stimulation increases LCFA but not glucose clearance in cardiac muscle in vivo. Shearer J, Fueger PT, Rottman JN, Bracy DP, Martin PH, Wasserman DH (2004) Am J Physiol Endocrinol Metab 287: E871-7 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside renders glucose output by the liver of the dog insensitive to a pharmacological increment in insulin. Camacho RC, Lacy DB, James FD, Donahue EP, Wasserman DH (2005) Am J Physiol Endocrinol Metab 289: E1039-43 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites. Picklo MJ, Amarnath V, McIntyre JO, Graham DG, Montine TJ (1999) J Neurochem 72: 1617-24 A novel in vitro assay for deubiquitination of I kappa B alpha. Strayhorn WD, Wadzinski BE (2002) Arch Biochem Biophys 400: 76-84 Methylmalonate toxicity in primary neuronal cultures. McLaughlin BA, Nelson D, Silver IA, Erecinska M, Chesselet MF (1998) Neuroscience 86: 279-90 Accessory proteins that control the assembly of MHC molecules with peptides. Van Kaer L (2001) Immunol Res 23: 205-14 Autotaxin as a novel serum marker of liver fibrosis. Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y, Iwai T, Suzuki A, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki J, Koike K, Yatomi Y (2011) Clin Chim Acta 412: 1201-6
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.