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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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- Anthracyclines and heart failure.
Sawyer DB
(2013) N Engl J Med 368: 1154-6 - Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM
(2001) Nature 413: 131-8 - Deterministic direct reprogramming of somatic cells to pluripotency.
Rais Y, Zviran A, Geula S, Gafni O, Chomsky E, Viukov S, Mansour AA, Caspi I, Krupalnik V, Zerbib M, Maza I, Mor N, Baran D, Weinberger L, Jaitin DA, Lara-Astiaso D, Blecher-Gonen R, Shipony Z, Mukamel Z, Hagai T, Gilad S, Amann-Zalcenstein D, Tanay A, Amit I, Novershtern N, Hanna JH
(2013) Nature 502: 65-70 - Intracellular signalling. Key enzyme in leptin-induced anorexia.
Niswender KD, Morton GJ, Stearns WH, Rhodes CJ, Myers MG, Schwartz MW
(2001) Nature 413: 794-5 - Alternative production of calcitonin and CGRP mRNA is regulated at the calcitonin-specific splice acceptor.
Emeson RB, Hedjran F, Yeakley JM, Guise JW, Rosenfeld MG
(1989) Nature 341: 76-80 - Patterns and rates of exonic de novo mutations in autism spectrum disorders.
Neale BM, Kou Y, Liu L, Ma'ayan A, Samocha KE, Sabo A, Lin CF, Stevens C, Wang LS, Makarov V, Polak P, Yoon S, Maguire J, Crawford EL, Campbell NG, Geller ET, Valladares O, Schafer C, Liu H, Zhao T, Cai G, Lihm J, Dannenfelser R, Jabado O, Peralta Z, Nagaswamy U, Muzny D, Reid JG, Newsham I, Wu Y, Lewis L, Han Y, Voight BF, Lim E, Rossin E, Kirby A, Flannick J, Fromer M, Shakir K, Fennell T, Garimella K, Banks E, Poplin R, Gabriel S, DePristo M, Wimbish JR, Boone BE, Levy SE, Betancur C, Sunyaev S, Boerwinkle E, Buxbaum JD, Cook EH, Devlin B, Gibbs RA, Roeder K, Schellenberg GD, Sutcliffe JS, Daly MJ
(2012) Nature 485: 242-5 - The transcription factor NF-ATc is essential for cardiac valve formation.
Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH
(1998) Nature 392: 186-90 - NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
Tooley CE, Petkowski JJ, Muratore-Schroeder TL, Balsbaugh JL, Shabanowitz J, Sabat M, Minor W, Hunt DF, Macara IG
(2010) Nature 466: 1125-8 - Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity.
Litingtung Y, Dahn RD, Li Y, Fallon JF, Chiang C
(2002) Nature 418: 979-83 - Comprehensive genomic profiles of small cell lung cancer.
George J, Lim JS, Jang SJ, Cun Y, Ozretić L, Kong G, Leenders F, Lu X, Fernández-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Pützer B, Bos M, Michels S, Vlasic I, Seidel D, Pinther B, Schaub P, Becker C, Altmüller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Chen Y, Soltermann A, Tischler V, Choi CM, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castaños-Vélez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Köhler J, Schuler M, Botling J, Sandelin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Lang U, Bogus M, Schneider PM, Zander T, Ansén S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt C, Perner S, Heukamp L, Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK
(2015) Nature 524: 47-53 - Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S, Cox NJ, Fajans SS, Signorini S, Stoffel M, Bell GI
(1996) Nature 384: 458-60 - Gal4 turnover and transcription activation.
Collins GA, Lipford JR, Deshaies RJ, Tansey WP
(2009) Nature 461: E7; discussion E8 - TBP-associated factors are not generally required for transcriptional activation in yeast.
Moqtaderi Z, Bai Y, Poon D, Weil PA, Struhl K
(1996) Nature 383: 188-91 - Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, Southam L, Cox RD, Lathrop GM, Boriraj VV, Chen X, Cox NJ, Oda Y, Yano H, Le Beau MM, Yamada S, Nishigori H, Takeda J, Fajans SS, Hattersley AT, Iwasaki N, Hansen T, Pedersen O, Polonsky KS, Bell GI
(1996) Nature 384: 455-8 - Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis.
Bushdid PB, Brantley DM, Yull FE, Blaeuer GL, Hoffman LH, Niswander L, Kerr LD
(1998) Nature 392: 615-8 - Integrated genomic and molecular characterization of cervical cancer.
Cancer Genome Atlas Research Network, Albert Einstein College of Medicine, Analytical Biological Services, Barretos Cancer Hospital, Baylor College of Medicine, Beckman Research Institute of City of Hope, Buck Institute for Research on Aging, Canada's Michael Smith Genome Sciences Centre, Harvard Medical School, Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services, HudsonAlpha Institute for Biotechnology, ILSbio, LLC, Indiana University School of Medicine, Institute of Human Virology, Institute for Systems Biology, International Genomics Consortium, Leidos Biomedical, Massachusetts General Hospital, McDonnell Genome Institute at Washington University, Medical College of Wisconsin, Medical University of South Carolina, Memorial Sloan Kettering Cancer Center, Montefiore Medical Center, NantOmics, National Cancer Institute, National Hospital, Abuja, Nigeria, National Human Genome Research Institute, National Institute of Environmental Health Sciences, National Institute on Deafness &Other Communication Disorders, Ontario Tumour Bank, London Health Sciences Centre, Ontario Tumour Bank, Ontario Institute for Cancer Research, Ontario Tumour Bank, The Ottawa Hospital, Oregon Health &Science University, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, SRA International, St Joseph's Candler Health System, Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University, Research Institute at Nationwide Children's Hospital, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, University of Bergen, University of Texas MD Anderson Cancer Center, University of Abuja Teaching Hospital, University of Alabama at Birmingham, University of California, Irvine, University of California Santa Cruz, University of Kansas Medical Center, University of Lausanne, University of New Mexico Health Sciences Center, University of North Carolina at Chapel Hill, University of Oklahoma Health Sciences Center, University of Pittsburgh, University of São Paulo, Ribeir ão Preto Medical School, University of Southern California, University of Washington, University of Wisconsin School of Medicine &Public Health, Van Andel Research Institute, Washington University in St Louis
(2017) Nature 543: 378-384 - ATR: an essential regulator of genome integrity.
Cimprich KA, Cortez D
(2008) Nat Rev Mol Cell Biol 9: 616-27 - Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.
Silva JP, Köhler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG
(2000) Nat Genet 26: 336-40 - Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model.
Southard-Smith EM, Kos L, Pavan WJ
(1998) Nat Genet 18: 60-4 - Sonic hedgehog is essential to foregut development.
Litingtung Y, Lei L, Westphal H, Chiang C
(1998) Nat Genet 20: 58-61 - The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing.
Muratani M, Kung C, Shokat KM, Tansey WP
(2005) Cell 120: 887-99 - p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.
Wildenberg GA, Dohn MR, Carnahan RH, Davis MA, Lobdell NA, Settleman J, Reynolds AB
(2006) Cell 127: 1027-39 - Bid plays a role in the DNA damage response.
Zinkel SS, Hurov KE, Gross A
(2007) Cell 130: 9-10; author reply 10-1 - Mus81-Eme1 are essential components of a Holliday junction resolvase.
Boddy MN, Gaillard PHL, McDonald WH, Shanahan P, Yates JR, Russell P
(2001) Cell 107: 537-48 - Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.
Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Schöler H, Smith A
(1998) Cell 95: 379-91 - Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.
Ericson J, Rashbass P, Schedl A, Brenner-Morton S, Kawakami A, van Heyningen V, Jessell TM, Briscoe J
(1997) Cell 90: 169-80 - AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.
Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR
(1996) Cell 84: 321-30 - Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA.
Mer G, Bochkarev A, Gupta R, Bochkareva E, Frappier L, Ingles CJ, Edwards AM, Chazin WJ
(2000) Cell 103: 449-56 - HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA.
Mohni KN, Wessel SR, Zhao R, Wojciechowski AC, Luzwick JW, Layden H, Eichman BF, Thompson PS, Mehta KPM, Cortez D
(2019) Cell 176: 144-153.e13 - A gradient of homeodomain protein in developing forelimbs of Xenopus and mouse embryos.
Oliver G, Wright CV, Hardwicke J, De Robertis EM
(1988) Cell 55: 1017-24 - TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.
Pietenpol JA, Stein RW, Moran E, Yaciuk P, Schlegel R, Lyons RM, Pittelkow MR, Münger K, Howley PM, Moses HL
(1990) Cell 61: 777-85 - A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins.
Murre C, McCaw PS, Baltimore D
(1989) Cell 56: 777-83 - Overexpression of a homeodomain protein confers axis-forming activity to uncommitted Xenopus embryonic cells.
Cho KW, Morita EA, Wright CV, De Robertis EM
(1991) Cell 65: 55-64 - Single cell profiling of potentiated phospho-protein networks in cancer cells.
Irish JM, Hovland R, Krutzik PO, Perez OD, Bruserud Ø, Gjertsen BT, Nolan GP
(2004) Cell 118: 217-28 - Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A.
Mudryj M, Devoto SH, Hiebert SW, Hunter T, Pines J, Nevins JR
(1991) Cell 65: 1243-53 - Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence.
Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, Jan YN, Cabrera CV, Buskin JN, Hauschka SD, Lassar AB
(1989) Cell 58: 537-44 - Interference with function of a homeobox gene in Xenopus embryos produces malformations of the anterior spinal cord.
Wright CV, Cho KW, Hardwicke J, Collins RH, De Robertis EM
(1989) Cell 59: 81-93 - A role for proapoptotic BID in the DNA-damage response.
Zinkel SS, Hurov KE, Ong C, Abtahi FM, Gross A, Korsmeyer SJ
(2005) Cell 122: 579-91 - Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.
Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM
(2014) Cell 156: 304-16 - The E2F transcription factor is a cellular target for the RB protein.
Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR
(1991) Cell 65: 1053-61
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