Keyword Connections

•  David Wooten
•  Lauren Woodard

•  Manuel Ascano
•  Pampee Young

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• Young Lab

Publications

• Heart repair by reprogramming non-myocytes with cardiac transcription factors.
  Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN
  (2012) Nature 485: 599-604
• Deterministic direct reprogramming of somatic cells to pluripotency.
  Rais Y, Zviran A, Geula S, Gafni O, Chomsky E, Viukov S, Mansour AA, Caspi I, Krupalnik V, Zerbib M, Maza I, Mor N, Baran D, Weinberger L, Jaitin DA, Lara-Astiaso D, Blecher-Gonen R, Shipony Z, Mukamel Z, Hagai T, Gilad S, Amann-Zalcenstein D, Tanay A, Amit I, Novershtern N, Hanna JH
  (2013) Nature 502: 65-70
• Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.
  Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC
  (2013) Cell 155: 844-57
• NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines.
  van Montfoort N, Borst L, Korrer MJ, Sluijter M, Marijt KA, Santegoets SJ, van Ham VJ, Ehsan I, Charoentong P, André P, Wagtmann N, Welters MJP, Kim YJ, Piersma SJ, van der Burg SH, van Hall T
  (2018) Cell 175: 1744-1755.e15
• Transgenic HLA-DR alpha faithfully reconstitutes IE-controlled immune functions and induces cross-tolerance to E alpha in E alpha 0 mutant mice.
  Lawrance SK, Karlsson L, Price J, Quaranta V, Ron Y, Sprent J, Peterson PA
  (1989) Cell 58: 583-94
• Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.
  Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC
  (2009) Cancer Cell 16: 115-25
• p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
  Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I
  (2016) Nat Med 22: 412-20
• Heart repair by cardiac reprogramming.
  Nam YJ, Song K, Olson EN
  (2013) Nat Med 19: 413-5
• Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.
  Kennedy AL, Morton JP, Manoharan I, Nelson DM, Jamieson NB, Pawlikowski JS, McBryan T, Doyle B, McKay C, Oien KA, Enders GH, Zhang R, Sansom OJ, Adams PD
  (2011) Mol Cell 42: 36-49
• Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors.
  Chatzigeorgiou M, Yoo S, Watson JD, Lee WH, Spencer WC, Kindt KS, Hwang SW, Miller DM, Treinin M, Driscoll M, Schafer WR
  (2010) Nat Neurosci 13: 861-8
• Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism.
  Chen X, Talati M, Fessel JP, Hemnes AR, Gladson S, French J, Shay S, Trammell A, Phillips JA, Hamid R, Cogan JD, Dawson EP, Womble KE, Hedges LK, Martinez EG, Wheeler LA, Loyd JE, Majka SJ, West J, Austin ED
  (2016) Circulation 133: 82-97
• Age Mosaicism across Multiple Scales in Adult Tissues.
  Arrojo E Drigo R, Lev-Ram V, Tyagi S, Ramachandra R, Deerinck T, Bushong E, Phan S, Orphan V, Lechene C, Ellisman MH, Hetzer MW
  (2019) Cell Metab 30: 343-351.e3
• Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment.
  Vilgelm AE, Johnson CA, Prasad N, Yang J, Chen SC, Ayers GD, Pawlikowski JS, Raman D, Sosman JA, Kelley M, Ecsedy JA, Shyr Y, Levy SE, Richmond A
  (2016) J Natl Cancer Inst 108: djv406
• The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells.
  Kitamura H, Iwakabe K, Yahata T, Nishimura S, Ohta A, Ohmi Y, Sato M, Takeda K, Okumura K, Van Kaer L, Kawano T, Taniguchi M, Nishimura T
  (1999) J Exp Med 189: 1121-8
• Immune cell populations in cutaneous delayed-type hypersensitivity.
  Platt JL, Grant BW, Eddy AA, Michael AF
  (1983) J Exp Med 158: 1227-42
• The plastic pancreas.
  Ziv O, Glaser B, Dor Y
  (2013) Dev Cell 26: 3-7
• Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
  Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P
  (2013) Dev Cell 26: 86-100
• Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production.
  Chaturvedi R, Asim M, Hoge S, Lewis ND, Singh K, Barry DP, de Sablet T, Piazuelo MB, Sarvaria AR, Cheng Y, Closs EI, Casero RA, Gobert AP, Wilson KT
  (2010) Gastroenterology 139: 1686-98, 1698.e1-6
• Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.
  Atherton JC, Peek RM, Tham KT, Cover TL, Blaser MJ
  (1997) Gastroenterology 112: 92-9
• Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach.
  Burclaff J, Osaki LH, Liu D, Goldenring JR, Mills JC
  (2017) Gastroenterology 152: 762-766.e7
• Tumor Necrosis Factor Receptor 2 Restricts the Pathogenicity of CD8(+) T Cells in Mice With Colitis.
  Punit S, Dubé PE, Liu CY, Girish N, Washington MK, Polk DB
  (2015) Gastroenterology 149: 993-1005.e2
• Mycobacterium tuberculosis programs mesenchymal stem cells to establish dormancy and persistence.
  Fatima S, Kamble SS, Dwivedi VP, Bhattacharya D, Kumar S, Ranganathan A, Van Kaer L, Mohanty S, Das G
  (2020) J Clin Invest 130: 655-661
• Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension.
  Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan J, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, Waxman AB, Parikh VN, De Marco T, Hsue PY, Morris A, Simon MA, Norris KA, Gaggioli C, Loscalzo J, Fessel J, Chan SY
  (2016) J Clin Invest 126: 3313-35
• KIM-1-mediated phagocytosis reduces acute injury to the kidney.
  Yang L, Brooks CR, Xiao S, Sabbisetti V, Yeung MY, Hsiao LL, Ichimura T, Kuchroo V, Bonventre JV
  (2015) J Clin Invest 125: 1620-36
• TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer.
  Bhola NE, Balko JM, Dugger TC, Kuba MG, Sánchez V, Sanders M, Stanford J, Cook RS, Arteaga CL
  (2013) J Clin Invest 123: 1348-58
• Two waves of de novo methylation during mouse germ cell development.
  Molaro A, Falciatori I, Hodges E, Aravin AA, Marran K, Rafii S, McCombie WR, Smith AD, Hannon GJ
  (2014) Genes Dev 28: 1544-9
• Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase.
  Sasaki T, Lian S, Khan A, Llop JR, Samuelson AV, Chen W, Klionsky DJ, Kishi S
  (2017) Autophagy 13: 386-403
• Regulation of tetrahydrobiopterin biosynthesis by shear stress.
  Widder JD, Chen W, Li L, Dikalov S, Thöny B, Hatakeyama K, Harrison DG
  (2007) Circ Res 101: 830-8
• Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II-Induced Hypertension.
  Xiao L, Kirabo A, Wu J, Saleh MA, Zhu L, Wang F, Takahashi T, Loperena R, Foss JD, Mernaugh RL, Chen W, Roberts J, Osborn JW, Itani HA, Harrison DG
  (2015) Circ Res 117: 547-57
• Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin.
  Erdogan B, Ao M, White LM, Means AL, Brewer BM, Yang L, Washington MK, Shi C, Franco OE, Weaver AM, Hayward SW, Li D, Webb DJ
  (2017) J Cell Biol 216: 3799-3816
• Lysosome-mediated processing of chromatin in senescence.
  Ivanov A, Pawlikowski J, Manoharan I, van Tuyn J, Nelson DM, Rai TS, Shah PP, Hewitt G, Korolchuk VI, Passos JF, Wu H, Berger SL, Adams PD
  (2013) J Cell Biol 202: 129-43
• A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells.
  Burnette DT, Shao L, Ott C, Pasapera AM, Fischer RS, Baird MA, Der Loughian C, Delanoe-Ayari H, Paszek MJ, Davidson MW, Betzig E, Lippincott-Schwartz J
  (2014) J Cell Biol 205: 83-96
• Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.
  Mudhasani R, Zhu Z, Hutvagner G, Eischen CM, Lyle S, Hall LL, Lawrence JB, Imbalzano AN, Jones SN
  (2008) J Cell Biol 181: 1055-63
• Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence.
  Balko JM, Schwarz LJ, Luo N, Estrada MV, Giltnane JM, Dávila-González D, Wang K, Sánchez V, Dean PT, Combs SE, Hicks D, Pinto JA, Landis MD, Doimi FD, Yelensky R, Miller VA, Stephens PJ, Rimm DL, Gómez H, Chang JC, Sanders ME, Cook RS, Arteaga CL
  (2016) Sci Transl Med 8: 334ra53
• A novel model of urinary tract differentiation, tissue regeneration, and disease: reprogramming human prostate and bladder cells into induced pluripotent stem cells.
  Moad M, Pal D, Hepburn AC, Williamson SC, Wilson L, Lako M, Armstrong L, Hayward SW, Franco OE, Cates JM, Fordham SE, Przyborski S, Carr-Wilkinson J, Robson CN, Heer R
  (2013) Eur Urol 64: 753-61
• Genetic architecture of host proteins involved in SARS-CoV-2 infection.
  Pietzner M, Wheeler E, Carrasco-Zanini J, Raffler J, Kerrison ND, Oerton E, Auyeung VPW, Luan J, Finan C, Casas JP, Ostroff R, Williams SA, Kastenmüller G, Ralser M, Gamazon ER, Wareham NJ, Hingorani AD, Langenberg C
  (2020) Nat Commun 11: 6397
• KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation.
  Brooks CR, Yeung MY, Brooks YS, Chen H, Ichimura T, Henderson JM, Bonventre JV
  (2015) EMBO J 34: 2441-64
• A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.
  Torre-Amione G, Beauchamp RD, Koeppen H, Park BH, Schreiber H, Moses HL, Rowley DA
  (1990) Proc Natl Acad Sci U S A 87: 1486-90
• The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis.
  Ooi JD, Chang J, Hickey MJ, Borza DB, Fugger L, Holdsworth SR, Kitching AR
  (2012) Proc Natl Acad Sci U S A 109: E2615-24
• Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.
  Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK
  (2012) Proc Natl Acad Sci U S A 109: 12105-10