"One-pot" syntheses of malondialdehyde adducts of nucleosides.

Szekely J, Wang H, Peplowski KM, Knutson CG, Marnett LJ, Rizzo CJ
Nucleosides Nucleotides Nucleic Acids. 2008 27 (2): 103-9

PMID: 18205065 · PMCID: PMC3129002 · DOI:10.1080/15257770701795797

Short, "one-pot" syntheses of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine are described. These syntheses proceed in improved yield and easier purification than previous syntheses and are well suited for the preparation of isotopically labeled nucleoside adducts for biomarker and metabolic studies.

MeSH Terms (3)

DNA Adducts Malondialdehyde Nucleosides

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