Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging.

Sinha TK, Khatib-Shahidi S, Yankeelov TE, Mapara K, Ehtesham M, Cornett DS, Dawant BM, Caprioli RM, Gore JC
Nat Methods. 2008 5 (1): 57-9

PMID: 18084298 · PMCID: PMC2649801 · DOI:10.1038/nmeth1147

We have developed a method for integrating three dimensional-volume reconstructions of spatially resolved matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) ion images of whole mouse heads with high-resolution images from other modalities in an animal-specific manner. This approach enabled us to analyze proteomic profiles from MALDI IMS data with corresponding in vivo data provided by magnetic resonance imaging.

MeSH Terms (10)

Animals Brain Imaging, Three-Dimensional Magnetic Resonance Imaging Mice Peptide Mapping Proteome Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Systems Integration Tissue Distribution

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