Comparison of fMRI statistical software packages and strategies for analysis of images containing random and stimulus-correlated motion.

Morgan VL, Dawant BM, Li Y, Pickens DR
Comput Med Imaging Graph. 2007 31 (6): 436-46

PMID: 17574816 · PMCID: PMC2570159 · DOI:10.1016/j.compmedimag.2007.04.002

The objectives of this study were to use computer-generated phantoms containing real subject motion to: (1) compare the sensitivity of four commonly used fMRI software packages and (2) compare the sensitivity of three statistical analysis strategies with respect to motion correction. The results suggest that all four packages perform similarly in fMRI statistical analysis with SPM2 having slightly higher sensitivity. The most sensitive analysis technique was to perform motion correction and include the realignment parameters as regressors in the general linear model. This approach applies to all four packages examined and can be most beneficial when stimulus-correlated motion is present.

MeSH Terms (19)

Algorithms Artifacts Brain Brain Mapping Data Interpretation, Statistical Evoked Potentials Humans Image Enhancement Image Interpretation, Computer-Assisted Imaging, Three-Dimensional Magnetic Resonance Imaging Movement Phantoms, Imaging Physical Stimulation Reproducibility of Results Sensitivity and Specificity Software Software Validation Statistics as Topic

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