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Dissecting the role of bone marrow stromal cells on bone metastases.

Buenrostro D, Park SI, Sterling JA
Biomed Res Int. 2014 2014: 875305

PMID: 25054153 · PMCID: PMC4099112 · DOI:10.1155/2014/875305

Tumor-induced bone disease is a dynamic process that involves interactions with many cell types. Once metastatic cancer cells reach the bone, they are in contact with many different cell types that are present in the cell-rich bone marrow. These cells include the immune cells, myeloid cells, fibroblasts, osteoblasts, osteoclasts, and mesenchymal stem cells. Each of these cell populations can influence the behavior or gene expression of both the tumor cells and the bone microenvironment. Additionally, the tumor itself can alter the behavior of these bone marrow cells which further alters both the microenvironment and the tumor cells. While many groups focus on studying these interactions, much remains unknown. A better understanding of the interactions between the tumor cells and the bone microenvironment will improve our knowledge on how tumors establish in bone and may lead to improvements in diagnosing and treating bone metastases. This review details our current knowledge on the interactions between tumor cells that reside in bone and their microenvironment.

MeSH Terms (11)

Bone and Bones Bone Neoplasms Fibroblasts Humans Immune System Mesenchymal Stem Cells Neoplasm Metastasis Neoplasms Osteoblasts Osteoclasts Tumor Microenvironment

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