ALDH7A1 expression is associated with recurrence in patients with surgically resected non-small-cell lung carcinoma.

Giacalone NJ, Den RB, Eisenberg R, Chen H, Olson SJ, Massion PP, Carbone DP, Lu B
Future Oncol. 2013 9 (5): 737-45

PMID: 23647301 · PMCID: PMC5341386 · DOI:10.2217/fon.13.19

AIM - The purpose of this study was to describe the prognostic significance of ALDH7A1 in surgically treated non-small-cell lung carcinoma. (NSCLC).

MATERIALS & METHODS - We immunohistochemically analyzed ALDH7A1 expression in surgically resected NSCLC from 89 patients using a tissue microarray.

RESULTS - ALDH7A1 staining was positive in 43 patients and negative in 44 patients, with two tumor sections missing. For stage I NSCLC patients, ALDH7A1 positivity was associated with decreased recurrence-free and overall survival. Multivariate analysis demonstrated that ALDH7A1-expressing NSCLC tumors had a significantly higher incidence of lung cancer recurrence compared with patients with ALDH7A1-negative tumors, although there was no association with overall survival.

CONCLUSION - For patients with NSCLC, low ALDH7A1 expression was associated with a decreased incidence of cancer recurrence. Specifically in stage I patients, negative staining for ALDH7A1 was associated with improved recurrence-free and overall survival, suggesting a predictive role in surgically treated patients.

MeSH Terms (12)

Aldehyde Dehydrogenase Carcinoma, Non-Small-Cell Lung Disease-Free Survival Follow-Up Studies Gene Expression Regulation, Neoplastic Humans Kaplan-Meier Estimate Lung Neoplasms Male Neoplasm Recurrence, Local Neoplasm Staging Prognosis

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