The Role of Oxysterols in Human Cancer.

Kloudova A, Guengerich FP, Soucek P
Trends Endocrinol Metab. 2017 28 (7): 485-496

PMID: 28410994 · PMCID: PMC5474130 · DOI:10.1016/j.tem.2017.03.002

Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested in the diet. By modulating the activity of many proteins [e.g., liver X receptors (LXRs), oxysterol-binding proteins (OSBPs), some ATP-binding cassette (ABC) transporters], oxysterols can affect many cellular functions and influence various physiological processes (e.g., cholesterol metabolism, membrane fluidity regulation, intracellular signaling pathways). Therefore, the role of oxysterols is also important in pathological conditions (e.g., atherosclerosis, diabetes mellitus type 2, neurodegenerative disorders). Finally, current evidence suggests that oxysterols play a role in malignancies such as breast, prostate, colon, and bile duct cancer. This review summarizes the physiological importance of oxysterols in the human body with a special emphasis on their roles in various tumors.

Copyright © 2017 Elsevier Ltd. All rights reserved.

MeSH Terms (9)

Animals Cholesterol Female Humans Hydroxycholesterols Lipid Metabolism Male Metabolic Networks and Pathways Neoplasms

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