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New trends in cytochrome p450 research at the half-century mark.

Guengerich FP
J Biol Chem. 2013 288 (24): 17063-4

PMID: 23632015 · PMCID: PMC3682511 · DOI:10.1074/jbc.R113.466821

Cytochrome P450 enzymes have major roles in the metabolism of steroids, drugs, carcinogens, eicosanoids, and numerous other chemicals. The P450s are collectively considered the most diverse catalysts known in biochemistry, although they operate from a basic structural fold and catalytic mechanism. The four minireviews in this thematic series deal with the unusual aspects of catalytic reactions and electron transfer pathway organization, the structural diversity of P450s, and the expanding roles of P450s in disease and medicine.

MeSH Terms (8)

Animals Biomedical Research Cytochrome P-450 Enzyme System Humans Inactivation, Metabolic Molecular Biology Oxidation-Reduction Steroids

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