Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of dichloromethane.

Watanabe K, Guengerich FP
Chem Res Toxicol. 2006 19 (8): 1091-6

PMID: 16918250 · DOI:10.1021/tx060087n

Formyl chloride has been indirectly implicated as an intermediate in the oxidation of CH(2)Cl(2) and proposed to be a product of the oxidation of some other compounds. Formyl chloride was synthesized and added to aqueous solutions, with CO formed as a product. The presence of glutathione (GSH) did not reduce the yield of CO at any of the pH values tested. At pH >or= 9, a small amount of S-formyl GSH was detected (

MeSH Terms (12)

Animals Chromatography, Liquid Formates Glutathione Humans In Vitro Techniques Mass Spectrometry Methylene Chloride Microsomes, Liver Protein Binding Rats Rats, Sprague-Dawley

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