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Cell survival is dicey without Dicer.

Adams CM, Eischen CM
Mol Cell Oncol. 2014 1 (2)

PMID: 25558471 · PMCID: PMC4279215 · DOI:10.4161/23723548.2014.961825

The cellular requirements of Dicer, an essential miRNA processing enzyme, and the consequences of altered levels of it on tumorigenesis are incompletely understood. We review the effects of Dicer loss in cells of different origin and whether loss of p53 permits cell survival and growth in the absence of Dicer.

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