Inhibition of BMP signaling suppresses metastasis in mammary cancer.

Owens P, Pickup MW, Novitskiy SV, Giltnane JM, Gorska AE, Hopkins CR, Hong CC, Moses HL
Oncogene. 2015 34 (19): 2437-49

PMID: 24998846 · PMCID: PMC4689138 · DOI:10.1038/onc.2014.189

Bone morphogenetic proteins (BMPs) are secreted cytokines/growth factors that have differing roles in cancer. BMPs are overexpressed in human breast cancers, but loss of BMP signaling in mammary carcinomas can accelerate metastasis. We show that human breast cancers display active BMP signaling, which is rarely downregulated or homozygously deleted. We hypothesized that systemic inhibition of BMP signaling in both the tumor and the surrounding microenvironment could prevent tumor progression and metastasis. To test this hypothesis, we used DMH1, a BMP antagonist, in MMTV.PyVmT expressing mice. Treatment with DMH1 reduced lung metastasis and the tumors were less proliferative and more apoptotic. In the surrounding tumor microenvironment, treatment with DMH1 altered fibroblasts, lymphatic vessels and macrophages to be less tumor promoting. These results indicate that inhibition of BMP signaling may successfully target both the tumor and the surrounding microenvironment to reduce tumor burden and metastasis.

MeSH Terms (16)

Animals Bone Morphogenetic Proteins Female Fibroblasts Humans Lung Neoplasms Lymphatic Vessels Macrophages Mammary Neoplasms, Animal Mice Mice, Inbred C57BL Mice, Transgenic Pyrazoles Quinolines Signal Transduction Tumor Microenvironment

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