[The effect of the depolymerization and disintegration of the microtubular system on the cytoskeleton of untransformed and transformed cells].

Kaverina IN, Vasil'ev IuM
Tsitologiia. 1991 33 (12): 49-53

PMID: 1688146

How important are the changes of microtubule control for the realization of actin cortex changes during neoplastic transformation? To answer this question we studied the actin cytoskeleton and intermediate filaments condition after colcemid destruction or taxol disintegration of microtubule system in non-transformed cells BALB/c 3T3 and in the same cells transformed by Ha-ras gene. We have come to a conclusion that the differences between non-transformed and transformed cells in the actin cytoskeleton organization remain the same after specific inhibitor action on the microtubules; after the microtubules are destroyed the differences between the two cell types appear in the intermediate filament organization; there are reasons to assume that changes in the actin cortex structure may play the central role in morphological transformation expression.

MeSH Terms (14)

Actins Animals Cell Transformation, Neoplastic Clone Cells Cytoskeleton Demecolcine Fibroblasts Genes, ras Intermediate Filaments Mice Mice, Inbred BALB C Microtubules Paclitaxel Transfection

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