Methotrexate inhibits NF-κB activity via long intergenic (noncoding) RNA-p21 induction.

Spurlock CF, Tossberg JT, Matlock BK, Olsen NJ, Aune TM
Arthritis Rheumatol. 2014 66 (11): 2947-57

PMID: 25077978 · PMCID: PMC4211976 · DOI:10.1002/art.38805

MeSH Terms (20)

Adult Antirheumatic Agents Arthritis, Rheumatoid Cell Line Cells, Cultured Cyclin-Dependent Kinase Inhibitor p21 DNA-Activated Protein Kinase Dose-Response Relationship, Drug eIF-2 Kinase Female Humans Male Methotrexate Middle Aged Monocytes NF-kappa B Nuclear Proteins RNA, Long Noncoding T-Lymphocytes Tumor Suppressor Protein p53

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