Modeling human disease: a mouse model of acute kidney injury to chronic kidney disease progression after cardiac arrest.

Terker AS, de Caestecker M
Kidney Int. 2020 97 (1): 22-24

PMID: 31901349 · PMCID: PMC7197020 · DOI:10.1016/j.kint.2019.09.017

Matsushita et al. describe a model of acute kidney injury to chronic kidney disease progression in mice surviving cardiac arrest: mice develop severe acute kidney injury that initially recovers but is followed by the onset of impaired renal function on longer-term follow-up. These findings suggest that distinct cardiorenal toxicities and/or injury dynamics are operative in this cardiac arrest model that do not occur in traditional models of acute kidney injury, providing new opportunities for therapeutic and biomarker discovery for an important clinical problem.

Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

MeSH Terms (9)

Acute Kidney Injury Animals Cardio-Renal Syndrome Disease Progression Heart Arrest Humans Inflammation Mice Renal Insufficiency, Chronic

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