RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT.

Kryshtal DO, Blackwell DJ, Egly CL, Smith AN, Batiste SM, Johnston JN, Laver DR, Knollmann BC
Circ Res. 2021 128 (3): 321-331

PMID: 33297863 · PMCID: PMC7864884 · DOI:10.1161/CIRCRESAHA.120.316819

MeSH Terms (21)

Action Potentials Animals Anti-Arrhythmia Agents Calcium Channel Blockers Calcium Signaling Calsequestrin Disease Models, Animal Female Flecainide Heart Rate HEK293 Cells Humans Male Mice, Knockout Myocytes, Cardiac Phosphorylation Ryanodine Receptor Calcium Release Channel Sarcoplasmic Reticulum Sheep, Domestic Tachycardia, Ventricular Voltage-Gated Sodium Channel Blockers

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