Deciphering tumor heterogeneity from FFPE tissues: Its promise and challenges.

Simmons AJ, Lau KS
Mol Cell Oncol. 2017 4 (1): e1260191

PMID: 28197533 · PMCID: PMC5286981 · DOI:10.1080/23723556.2016.1260191

An impediment to the understanding of cancer is the heterogeneous nature of cell populations within a tumor microenvironment. We reported a method to query protein signaling in single epithelial cells from formalin-fixed paraffin-embedded (FFPE) colorectal cancer tissues. Here, we discuss the feasibility and limitations of this approach for investigating signaling state heterogeneity.

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