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A mathematical model quantifies proliferation and motility effects of TGF-β on cancer cells.

Wang SE, Hinow P, Bryce N, Weaver AM, Estrada L, Arteaga CL, Webb GF
Comput Math Methods Med. 2009 10 (1): 71-83

PMID: 26000030 · PMCID: PMC4437567 · DOI:10.1080/17486700802171993

Transforming growth factor (TGF)-β is known to have properties of both a tumour suppressor and a tumour promoter. While it inhibits cell proliferation, it also increases cell motility and decreases cell-cell adhesion. Coupling mathematical modelling and experiments, we investigate the growth and motility of oncogene-expressing human mammary epithelial cells under exposure to TGF-β. We use a version of the well-known Fisher-Kolmogorov equation, and prescribe a procedure for its parametrisation. We quantify the simultaneous effects of TGF-β to increase the tendency of individual cells and cell clusters to move randomly and to decrease overall population growth. We demonstrate that in experiments with TGF-β treated cells , TGF-β increases cell motility by a factor of 2 and decreases cell proliferation by a factor of 1/2 in comparison with untreated cells.

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