Acute pain in children and adults with sickle cell disease: management in the absence of evidence-based guidelines.

Field JJ, Knight-Perry JE, Debaun MR
Curr Opin Hematol. 2009 16 (3): 173-8

PMID: 19295432 · DOI:10.1097/MOH.0b013e328329e167

PURPOSE OF REVIEW - Acute, vaso-occlusive pain is the most characteristic complication of sickle cell disease (SCD). Although there has been rigorous work examining the pathogenesis of vaso-occlusion, fewer studies have focused on approaches to the clinical management of acute pain. In this review, we will examine the epidemiology and management strategies of acute pain events and we will identify limitations in the best available studies.

RECENT FINDINGS - Most acute pain events in adults with SCD are managed at home without physician contact. Prior descriptions of the natural history of pain episodes from the Cooperative Study of Sickle Cell Disease relied on physician contact, limiting the generalizability of these findings to current practice. Patient-controlled analgesia has replaced on-demand therapy to become the standard for management of severe pain events in children and adults with SCD requiring hospital admission.

SUMMARY - Unfortunately, most clinical practice guidelines for the management of acute pain are not based on randomized clinical trials. As a result, our practice of pain management is primarily limited to expert opinion and inferences from observational studies. Additional clinical trials in management of acute pain in children and adults with SCD are critical for the development of evidence-based guidelines.

MeSH Terms (9)

Acute Disease Adult Analgesia, Patient-Controlled Analgesics, Opioid Anemia, Sickle Cell Anti-Inflammatory Agents, Non-Steroidal Child Humans Pain

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