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Longitudinal analysis of pulmonary function in adults with sickle cell disease.

Field JJ, Glassberg J, Gilmore A, Howard J, Patankar S, Yan Y, Davies SC, Debaun MR, Strunk RC
Am J Hematol. 2008 83 (7): 574-6

PMID: 18383325 · PMCID: PMC3729267 · DOI:10.1002/ajh.21176

Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV(1) for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.

(c) 2008 Wiley-Liss, Inc.

MeSH Terms (9)

Adult Aged Anemia, Sickle Cell Female Humans Longitudinal Studies Lung Male Middle Aged

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