Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism.

Bridges TM, Rook JM, Noetzel MJ, Morrison RD, Zhou Y, Gogliotti RD, Vinson PN, Xiang Z, Jones CK, Niswender CM, Lindsley CW, Stauffer SR, Conn PJ, Daniels JS
Drug Metab Dispos. 2013 41 (9): 1703-14

PMID: 23821185 · PMCID: PMC3876804 · DOI:10.1124/dmd.113.052084

MeSH Terms (15)

Allosteric Regulation Animals Astrocytes Biotransformation Cell Line Cytochrome P-450 Enzyme System HEK293 Cells Hippocampus Humans Liver Male Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Seizures

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