Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor.

Salovich JM, Vinson PN, Sheffler DJ, Lamsal A, Utley TJ, Blobaum AL, Bridges TM, Le U, Jones CK, Wood MR, Daniels JS, Conn PJ, Niswender CM, Lindsley CW, Hopkins CR
Bioorg Med Chem Lett. 2012 22 (15): 5084-8

PMID: 22738637 · PMCID: PMC3401285 · DOI:10.1016/j.bmcl.2012.05.109

MeSH Terms (13)

Allosteric Regulation Amides Animals Brain CHO Cells Cricetinae Cricetulus Drug Evaluation, Preclinical Humans Niacinamide Rats Receptor, Muscarinic M4 Structure-Activity Relationship

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