Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator.

Utley T, Haddenham D, Salovich JM, Zamorano R, Vinson PN, Lindsley CW, Hopkins CR, Niswender CM
Bioorg Med Chem Lett. 2011 21 (23): 6955-9

PMID: 22030026 · PMCID: PMC3319082 · DOI:10.1016/j.bmcl.2011.09.131

MeSH Terms (11)

Allosteric Regulation Animals Cells, Cultured Drug Design Humans Inhibitory Concentration 50 Molecular Structure Pyridines Rats Receptors, Metabotropic Glutamate Structure-Activity Relationship

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