Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold.

Williams R, Manka JT, Rodriguez AL, Vinson PN, Niswender CM, Weaver CD, Jones CK, Conn PJ, Lindsley CW, Stauffer SR
Bioorg Med Chem Lett. 2011 21 (5): 1350-3

PMID: 21315585 · PMCID: PMC3498823 · DOI:10.1016/j.bmcl.2011.01.044

MeSH Terms (10)

Allosteric Regulation Animals Antipsychotic Agents Bridged Bicyclo Compounds Inhibitory Concentration 50 Lactams Molecular Structure Rats Receptors, Metabotropic Glutamate Structure-Activity Relationship

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