Outcomes of autologous or allogeneic stem cell transplantation for non-Hodgkin lymphoma.

Reddy NM, Oluwole O, Greer JP, Engelhardt BG, Jagasia MH, Savani BN
Exp Hematol. 2014 42 (1): 39-45

PMID: 24096123 · PMCID: PMC5002948 · DOI:10.1016/j.exphem.2013.09.012

Transplant outcomes of autologous or allogeneic stem cell transplantation (SCT) have not been elucidated as a single cohort in non-Hodgkin lymphoma (NHL). We analyzed the outcomes of 270 adult recipients receiving autologous (auto) SCT (n = 198) or allogeneic (allo) SCT (n = 72) for NHL between the years 2000 and 2010. Five-year overall survival rates for B and T cell NHL were 58% and 50%, respectively (allo-SCT 51% vs. 54% for B and T-cell NHL, and auto-SCT 60% vs. 47% for B and T cell lymphoma, respectively). In multivariate analysis, the number of chemotherapy regimens and disease status pre-SCT were independently associated with long-term outcome after SCT (for both auto- and allo-SCT). We conclude that the type of transplantation offered to patients, based on patient selection and disease-related factors, can achieve long-term survival, highlighting the importance of further improvement in disease control and reducing procedure-related mortality. The role of transplantation needs to be reevaluated in the era of targeted therapy.

Copyright © 2014 ISEH - Society for Hematology and Stem Cells. All rights reserved.

MeSH Terms (12)

Adult Aged Disease-Free Survival Female Hematopoietic Stem Cell Transplantation Humans Lymphoma, Non-Hodgkin Male Middle Aged Transplantation, Autologous Transplantation, Homologous Treatment Outcome

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