, a bio/informatics shared resource is still "open for business" - Visit the CDS website


Adult combination antiretroviral therapy in sub-Saharan Africa: lessons from Botswana and future challenges.

Wester CW, Bussmann H, Koethe J, Moffat C, Vermund S, Essex M, Marlink RG
HIV Ther. 2009 3 (5): 501-526

PMID: 20161344 · PMCID: PMC2774911 · DOI:10.2217/hiv.09.35

Numerous national public initiatives offering first-line combination antiretroviral therapy (cART) for HIV infection have commenced in sub-Saharan Africa since 2002. Presently, 2.1 million of an estimated seven million Africans in need of cART are receiving treatment. Analyses from the region report favorable clinical/treatment outcomes and impressive declines in AIDS-related mortality among HIV-1-infected adults and children receiving cART. While immunologic recovery, virologic suppression and cART adherence rates are on par with resource-rich settings, loss to follow-up and high mortality rates, especially within the first 6 months of treatment, remain a significant problem. Over the next decade, cART coverage rates are expected to improve across the region, with attendant increases in healthcare utilization for HIV- and non-HIV-related complications and the need for expanded laboratory and clinical services. Planned and in-progress trials will evaluate the use of cART to prevent primary HIV-1 infection with so-called 'test and treat' expansions of coverage and treatment. Education and training programs as well as patient-retention strategies will need to be strengthened as national cART programs are expanded and more people require lifelong monitoring and care.

MeSH Terms (0)

Connections (1)

This publication is referenced by other Labnodes entities:

Links